Fatma Meriç YILMAZ, Çiğdem TOPKAYA, Şenay Savaş ERDEVE, Yıldız DALLAR

Increased oxidative stress ın obese children

Amaç: Obezite artan lipid peroksidasyonu ile ilişkilidir. Lipid peroksidasyon sürecinin birkaç yan ürününden biri olan malondialdehid (MDA), lipid peroksidasyon düzeyini yansıtan biyolojik bir belirteçtir. Bu çalışmada obez çocuklarda oksidan hasarın belirlenmesi amaçladı. Gereç ve Yöntem: Otuz iki çocuk ve aynı yaş grubunda yirmi obez olmayan çocuk değerlendirildi. Olguların hiçbiri insülin düzeyini, insülin duyarlılığını veya oksidatif stresi etkileyecek ilaç almıyordu. Gece açlışı sonrası biyokimyasal parametreleri ve MDA düzeyini belirlemek için kan alındı. İnsülin direnci HOMA-IR kullanılarak değerlendirildi. Bulgular: Obez grup kontrol grubuyla karşılaştırıldığında anlamlı olarak yüksek açlık plazma insülin, açlık plazma glukozu, plazma kolesterolü, LDL-kolesterol ve yüksek kan basıncı değerlerine sahipti (p

Obez çocuklarda artmış oksidatif stres

Aim: Obesity is associated with enhanced lipid peroxidation. Malondialdehyde (MDA), one of several by-products of lipid peroxidation process, is a biomarker that provides an indication of lipid peroxidation level. It was aimed to determine the oxidant damage in obese children. Materials and Methods: Thirty two children with obesity and 20 age-matched non-obese children were evaluated. None of the subjects were receiving any medication that could affect insulin levels, insulin sensitivity, or oxidative stress. After overnight fasting, blood was drawn from an antecubital vein for determination of biochemical parameters and MDA levels. Insulin resistance was assessed at baseline by using the homeostasis model assessment (HOMA). Results: Obese group had significantly higher fasting plasma insulin, fasting plasma glucose, plasma cholesterol, LDL-cholesterol and increased blood pressure values as compared to controls (p

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