YENİ PİRİMİDO[1,2-a]PİRİMİDİN BİLEŞİKLERİNİN ANTİOKSİDAN VE ANTİBAKTERİYAL ÖZELLİKLERİNİN KARŞILAŞTIRILMASI
Amaç: Pirimidopirimidin yapı iskeletine sahip heterohalkalı bileşikler, sahip oldukları çok çeşitli biyolojik özellikleri sayesinde tıbbi kimya alanındaki araştırmacıların ilgi odağı olmuştur. Bu çalışma ile, bir seri yeni pirimido[1,2-a]pirimidin türevlerinin antioksidan kapasitesi ve antibakteriyel aktivitesi araştırılmıştır.
THE COMPARISON OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF NOVEL PYRIMIDO[1,2-a]PYRIMIDINE COMPOUNDS
Objective: Heterocycles with a pyrimidopyrimidine scaffold have been the focus of interest of researchers in the field of medicinal chemistry as they have a wide range of biological properties. In the current study antioxidant capacity and antibacterial activity of a series of new pyrimido[1,2-a]pyrimidines were investigated
___
- 1. Sahu, M., Siddiqui, N. (2016). A review on biological importance of pyrimidines in the new era. International Journal of Pharmaceutical Sciences Research, 8(5), 8-21.
- 2. Lagoja, I.M. (2005). Pyrimidine as constituent of natural biologically active compounds. Chemistry & Biodiversity, 2(1), 1-50. [CrossRef]
- 3. Baumann, M., Baxendale, I.R. (2013). An overview of the synthetic routes to the best-selling drugs containing 6-membered heterocycles. Beilstein Journal of Organic Chemistry, 9(1), 2265-2319. [CrossRef]
- 4. Abbas, S.E., Gawad, N.M.A., George, R.F., Akar, Y.A. (2013). Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo [4,5] thieno [2,3-d] pyrimidine derivatives. European Journal of Medicinal Chemistry, 65, 195-204. [CrossRef]
- 5. Buron, F., Mérour, J.Y., Akssira, M., Guillaumet, G., Routier, S. (2015). Recent advances in the chemistry and biology of pyridopyrimidines. European Journal of Medicinal Chemistry, 95, 76-95. [Crossref]
- 6. Hossan, A.S., Abu-Melha, H.M., Al-Omar, M.A., Amr, A.E.G.E. (2012). Synthesis and antimicrobial activity of some new pyrimidinone and oxazinone derivatives fused with thiophene rings using 2-chloro-6-ethoxy-4-acetylpyridine as starting material. Molecules, 17(11), 13642-13655. [CrossRef]
- 7. Asmat, U., Abad, K., Ismail, K. (2016). Diabetes mellitus and oxidative stress—A concise review. Saudi Pharmaceutical Journal, 24(5), 547-553. [CrossRef]
- 8. Rodrigo, R., Fernandez-Gajardo, R., Gutierrez, R., Manuel Matamala, J., Carrasco, R., Miranda-Merchak, A., Feuerhake, W. (2013). Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 12(5), 698-714. [CrossRef]
- 9. Biswas, S.K. (2016). Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxidative Medicine and Cellular Longevity, 2016. [CrossRef]
- 10. Naeem, A., Badshah, S.L., Muska, M., Ahmad, N., Khan, K. (2016). The current case of quinolones: synthetic approaches and antibacterial activity. Molecules, 21(4), 268. [CrossRef]
- 11. Andersson, M.I., MacGowan, A.P. (2003). Development of the quinolones. Journal of Antimicrobial Chemotherapy, 51(1), 1-11. [CrossRef]
- 12. Hurd, C.D., Hayao, S. (1955). Reaction of propiolactone with heterocyclic amines. Journal of the American Chemical Society, 77(1), 117-121. [CrossRef]
- 13. Kappe, T. (1967). Synthesen von Heterocyclen, 95. Mitt.: Chinolizine und Indolizine I: Eine Synthese von 2-Hydroxychinolizinonen-(4). Monatshefte für Chemie-Chemical Monthly, 98(3), 874-886. [CrossRef]
- 14. Güllü, M., Dinçsönmez, A., Özyavaş, Ö. (2010). Facile Synthesis of Novel Pyrimido[1, 2‐a]pyrimidin‐4‐ones from Highly Reactive Malonates. European Journal of Organic Chemistry, 11, 2113-2120. [CrossRef]
- 15. Bayramoğlu, D., Güllü, M. (2021). An Efficient Synthetic Method for the Synthesis of Novel Pyrimido [1,2-a] pyrimidine-3-carboxylates: Comparison of Microwave and Conventional Heating. Polycyclic Aromatic Compounds, 42(8), 4948-4964. [CrossRef]
- 16. The European Committee on Antimicrobial Susceptibility Testing Web site. (2022). From https://www.eucast.org. Erişim tarihi: 01.01.2022.
- 17. Alam, M.N., Bristi, N.J., Rafiquzzaman, M. (2013). Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharmaceutical Journal, 21(2), 143-152. [CrossRef]
- 18. Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199-1200. [CrossRef]
- 19. Leyva-Ramos, S., de Loera, D., Cardoso-Ortiz, J. (2017). In vitro antibacterial activity of 7-substituted-6-fluoroquinolone and 7-substituted-6,8-difluoroquinolone derivatives. Chemotherapy, 62, 194-198. [CrossRef]
- 20. Smith, A., Pennefather, P.M., Kaye, S.B., Hart, C.A. (2001). Fluoroquinolones. Drugs, 61(6), 747-761. [CrossRef]
- 21. The European Committee on Antimicrobial Susceptibility Testing Web site. (2022). From https://www.eucast.org Erişim tarihi: 01.01.2022.
- 22. Solca, F.F., Baum, A., Langkopf, E., Dahmann, G., Heider, K.H., Himmelsbach, F., Meel, J.C.A. (2004). Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. The journal of Pharmacaology and Experimental Therapeutics, 311(2), 502-509. [CrossRef]
- 23. Cruz, J.P., Carrasco, T., Ortega, G., Cuesta, F.S. (1992). Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids, 27(3), 192-194. [CrossRef]
- 24. Sharma, P., Rane, N., Pandey, P. (2006). Synthesis and evaluation of antimicrobial activity of novel hydrazino and N-benzylidinehydrazino-substituted 4,8-dihydro-1H,3H-pyrimido[4,5-d]pyrimidin-2,7-dithiones. Archiv de Pharmazie. 339(10), 572-578. [CrossRef]
- 25. Krueger, A.C., Madigan, D.L., Beno, D.W., Betebenner, D.A., Carrick, R., Green, B.E., He, W., Liu, D., Maring, C.J., Daniel, K.F., Mo, H., Molla, A., Motter, C.E., Pilot-Matias, T.J., Tufano, M.D., Kempf, D.J. (2012). Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters. 22(6), 2212-2215. [CrossRef]
- 26. Ellatar, K.M., Mert B.D., Monier, M., El-Mekabaty, A. (2020). Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds. RSC Advances, 10(26), 15461-15492. [CrossRef]
- 27. Saundane, A.R., Vjaykumar, K., Vaijinath, A.V., Walmik, P. (2013) Synthesis, antimicrobial and antioxidant activities of some new indole derivatives containing pyridopyrimidine and pyrazolopyridine moieties. Medicinal Chemistry Research, 22, 806-817. [CrossRef]