BESİFLOKSASİN HCL YÜKLÜ OKÜLER İN SİTU JELLERİN GELİŞTİRİLMESİ; İN VİTRO KARAKTERİZASYON ÇALIŞMASI

Amaç: Bu çalışmanın amacı, kornea temas süresi artırılmış, ilaç salımı düzenlenmiş, oküler biyoyararlanımı iyileştirilmiş ve hasta uyuncunu artırmak amacıyla jelleşme sıcaklığını değiştirecek farklı poloksomer türevlerinin ve mukoadhezyonu değiştirecek farklı polimerlerin kullanılması ile hazırlanan ısı ile tetiklenip jelleşen ve besifloksasin hidroklorür içeren in situ jel formülasyonları geliştirmektir.

Anahtar Kelimeler:

Besifloksasin HCl, in situ, jel, oküler, poloksamer

DEVELOPMENT OF BESIFLOXACIN HCL LOADED OCULAR IN SITU GELS; IN VITRO CHARACTERIZATION STUDY

Objective: The aim of this study is to develop in situ gel formulations containing besifloxacin hydrochloride are heat triggered, which are prepared by using different poloxamer and derivatives different polymers that will change the gelling temperature to increase corneal contact time, regulate drug release, improve ocular bioavailability and increase patient compliance increase mucoadhesion.

Keywords:

Besifloxacin HCl, gel, in situ, ocular, poloxamer,

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