DOKSORUBİSİN İLE OLUŞTURULAN KRONİK KALP YETMEZLİĞİ MODELİNDE VE Β-ADRENERJİK BLOKERLERİN KULLANIMI SIRASINDA SIÇANLARDA BÜTÜNLEYİCİ VE BİYOKİMYASAL PARAMETRELER

Amaç: Kronik kalp yetmezliğinin tedavisinde karvedilol, nebivolol, metoprolol, bisoprolol vb. β-blokerler aktif olarak kullanılmaktadır. Bununla birlikte, bir dizi ciddi yan etkileri bulunmakta olup tedavi edici etkinlikleri her zaman kliniğin ihtiyaçlarını karşılamamaktadır. Bütün bunlar yeni bir potansiyel ilacın (Hypertril, bromür 1-(β-feniletil)-4-amino-1,2,4-triazolyum)) geliştirilmesine yol açmaktadır. Farklı nesil β-blokerlerin ve Hipetrilin farkli koşullar altında (miyokard hasarının biyokimyasal belirteçleri ve integratif parametreler üzerindeki etkisi açısından kronik kalp yetmezliğinin (KKY) doksorubisin modellenmesiyle) karşılaştırmalı bir değerlendirmesinin yapılması amaçlanmıştır.

INTEGRATIVE AND BIOCHEMICAL PARAMETERS IN RATS IN THE SIMULATION OF DOXORUBICIN CHRONIC HEART FAILURE AND DURING THE USE OF Β-ADRENERGIC BLOCKERS

Objective: In the treatment of chronic heart failure, β-blockers are actively used - Carvedilol, Nebivolol, Metoprolol, Bisoprolol, etc. However, they have a number of serious adverse reactions, and their therapeutic efficacy does not always meet the needs of the clinic. All this prompted the creation of a new potential drug Hypertril (bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazolium. We aimed to conduct a comparative assessment of β-blockers of different generations and "Hypertril" in the conditions of modeling the doxorubicin model of chronic heart failure (CHF) in terms of the effect on biochemical markers of myocardial damage and integrative parameters.

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Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • ISSN: 1015-3918
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2016
  • Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi
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