MOLEKÜLER YERLEŞTİRME YÖNTEMİYLE ZERUMBONUN EGFR TİROZİN KİNAZ İNHİBİTÖRÜ OLARAK DEĞERLENDİRİLMESİ

Amaç: EGFR-TK bölgesi, başta akciğer kanseri olmak üzere çeşitli kanser türlerinin başlaması ve ilerlemesinde büyük önem taşımaktadır. Mevcut EGFR-TK inhibitörlerinin çeşitli yan etkilerinin varlığı, onların uygun kanser terapötikleri olarak kullanılmalarını sınırlandırmaktadır. Bu çalışmada, moleküler yerleştirme yaklaşımı ile EGFR'yi hedef alan bir antikanser ajan olarak zerumbonun aktivitesini analiz etmeyi ve aktivitesini kurkumin ile karşılaştırmalı olarak değerlendirmeyi amaçladık.

Anahtar Kelimeler:

Akciğer kanseri, epidermal büyüme faktörü reseptörü, kurkumin, moleküler yerleştirme, zerumbon

EVALUATION OF ZERUMBONE AS AN EGFR TYROSINE KINASE INHIBITOR BY MOLECULAR DOCKING METHOD

Objective: EGFR-TK domain is of great importance in the initiation and progression of various cancer types, especially lung cancer. The existing EGFR-TK inhibitors have numerous side effects, which make them improper to be utilized as cancer therapeutics. In this study, we aimed to analyze the activity of zerumbone as an anticancer agent targeting EGFR by molecular docking approach and to evaluate its activity in comparison with curcumin.

Keywords:

Curcumin, epidermal growth factor receptor, lung cancer, molecular docking, zerumbone,

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