Dmytro OLIINYKOV, Andrii KAPLAUSHENKO, Svetlana TREHUB, Katerina KOVALYOVA

MODİFİYE SALIMLI İSOSORBİT DİNİTRAT KÜRESEL GRANÜLLERİNİN ÜRETİMİ

Amaç: Bu çalışma, etkin maddenin kontrollü salımını yapan çok dozlu bir tıbbi form oluşturmak için farklı çözünme kinetiklerine sahip izosorbit dinitratın küresel matris pelletlerini elde etmeyi amaçlamıştır.

MANUFACTURE OF SPHERICAL GRANULES OF ISOSORBIDE DINITRATE WITH MODIFIED RELEASE

Objective: This study was aimed to obtain spherical matrix pellets of isosorbide dinitrate with different dissolution kinetics to create a multidosage medicinal form with controlled release of the active substance.

Keywords:

Isosorbide dinitrate, release profile, spherical matrix pellets,

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