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• 1. Lalla, R. V., Peterson, D. E. (2005). Oral mucositis. Dental Clinics of North America, 49 (1 SPEC.ISS.), 167–184.
• 2. Trotti, A., Bellm, L.A., Epstein, J. B., Frame, D., Fuchs, H. J., Gwede, C. K., Komaroff, E., Nalysnyk, L., Zilberberg, M.D. (2003). Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review. Radiotherapy and Oncology, 66 (3), 253-62.
• 3. Itoh, Y., Kubota, S., Kawamura, M., Nomoto, Y., Murao, T., Yamakawa, K., Ishihara, S., Hirasawa, N., Asano, A., Yanagawa, S., Naganawa, S. (2016). A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis. Nagoya Journal of Medical Science, 78 (4), 399–406.
• 4. Donnelly, J. P., Bellm, L. A., Epstein, J. B., Sonis, S. T., Symonds, R. P. (2003). Antimicrobial therapy to prevent or treat oral mucositis. Lancet Infectious Diseases, 3 (7), 405–412.
• 5. Mosel, D. D., Bauer, R. L., Lynch, D. P., Hwang, S. T. (2011). Oral complications in the treatment of cancer patients. Oral Diseases, 17 (6), 550–559.
• 6. Villa, A., Sonis, S. T. (2015). Mucositis: Pathobiology and management. Current Opinion in Oncology, 27 (3), 159–164.
• 7. Chan, A., Ignoffo, R.J. (2005). Survey of topical oral solutions for the treatment of chemo-induced oral mucositis. Journal of Oncology Pharmacy Practice, 11 (4), 139–143.
• 8. Buchsel, P. C. (2008). Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair®): A bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opinion on Drug Metabolism and Toxicology, 4 (11), 1449–1454.
• 9. Carl, W., Emrich, L. S. (1991). Management of oral mucositis during local radiation and systemic chemotherapy: A study of 98 patients. The Journal of Prosthetic Dentistry, 66 (3), 361–369.
• 10. Leiknes, T., Leknes, K. N., Böe, O. E., Skavland, R. J., Lie, T. (2007). Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation. Journal of Periodontology, 78 (8), 1538–1544.
• 11. Jones, D. S., Woolfson, A. D., Brown, A. F., Coulter, W. A., McClelland, C., Irwin, C. R. (2000). Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. Journal of Controlled Release, 67 (2–3), 357–368.
• 12. Kaur, J., Kaur, J., Jaiswal, S., Gupta, G. (2016). Recent advances in topical drug delivery system. Pharmaceutical Research, 6 (07), 6353-6369.
• 13. Patil, P. B., Datir, S. K., Saudagar, R. B. (2019). A review on topical gels as drug delivery system P.B. Journal of Drug Delivery and Therapeutics, 3 (3-s), 989–994.
• 14. Agrawal, A. K., Das, M., and Jain, S. (2012). In situ gel systems as “smart” carriers for sustained ocular drug delivery. Expert Opinion on Drug Delivery, 9 (4), 383–402.
• 15. Baloglu, E., Karavana, S. Y., Senyigit, Z. A., Guneri, T. (2011). Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base. Pharmaceutical Development and Technology, 16 (6), 627–636.
• 16. Kabanov, A. V., Batrakova, E. V., Miller, D. W. (2003). Pluronic® block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Advanced Drug Delivery Reviews, 55 (1), 151–164.
• 17. Maynard, C., Swenson, R., Paris, J. A., Martin, J. S., Hallstrom, A. P., Cerqueira, M. D., Weaver, W. D. (1998). Randomized, controlled trial of RheothRx (poloxamer 188) in patients with suspected acute myocardial infarction. American Heart Journal, 135(5 I), 797–804.
• 18. Singh, S., Parhi, R., Garg, A. (2011). Formulation of topical bioadhesive gel of aceclofenac using 3-level factorial design. Iranian Journal of Pharmaceutical Research, 10 (3), 435-45.
• 19. Shin, S. C., Kim, J. Y., Oh, I. J. (2000). Mucoadhesive and physicochemical characterization of Carbopol-poloxamer gels containing triamcinolone acetonide. Drug Development and Industrial Pharmacy, 26 (3), 307–312.
• 20. BASF Web site. (2017). Retrieved May 22, 2020, from https://pharmaceutical.basf.com/
• 21. Valenta, C. (2005). The use of mucoadhesive polymers in vaginal delivery. Advanced Drug Delivery Reviews, 57 (11), 1692-712.
• 22. Tuğcu-Demiröz, F. (2017). Development of in situ poloxamer-chitosan hydrogels for vaginal drug delivery of benzydamine hydrochloride: Textural, mucoadhesive and in vitro release properties. Marmara Pharmaceutical Journal, 21 (4), 762–770.
• 23. Marques, M. R. C., Loebenberg, R., Almukainzi, M. (2011). Simulated biological fluids with possible application in dissolution testing. Dissolution Technologies, 18 (3), 15-27.
• 24. Tuğcu-Demiröz, F., Acartürk, F., Özkul, A. (2015). Preparation and characterization of bioadhesive controlled-release gels of cidofovir for vaginal delivery. Journal of Biomaterials Science, Polymer Edition, 26 (17), 1237-1255.
• 25. Tuǧcu-Demiröz, F., Acartürk, F., Erdoǧan, D. (2013). Development of long-acting bioadhesive vaginal gels of oxybutynin: Formulation, in vitro and in vivo evaluations. International Journal of Pharmaceutics, 457 (1), 25-39.
• 26. Patel, P., Varshney, P., Rohit, M. (2014). Analytical method development and validation for simultaneous estimation of metronidazole and amoxicillin in synthetic mixture by UV- visible spectroscopy. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (SUPPL. 2), 317–319.
• 27. de Francisco, L. M. B., Rosseto, H. C., de Alcântara Sica de Toledo, L., dos Santos, R.S., de Souza Ferreira, S. B., Bruschi, M. L. (2019). Organogel composed of poloxamer 188 and passion fruit oil: Sol-gel transition, rheology, and mechanical properties. Journal of Molecular Liquids, 289, 111170.
• 28. Jones, D.S., Woolfson, A. D., Brown, A. F. (1997). Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. International Journal of Pharmaceutics, 151 (2), 223–233.
• 29. Amasya, G., Karavana, S. Y., Şen, T., Baloǧlu, E., Tarimci, N. (2012). Bioadhesive and mechanical properties of triamcinolone acetonide buccal gels. Turkish Journal of Pharmaceutical Sciences, 9 (1), 1–11.
• 30. Cevher, E., Taha, M. A. M., Orlu, M., Araman, A. (2008). Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives. Drug Delivery, 15 (1), 57–67
• 31. Sorasitthiyanukarn, F. N., Rojsitthisak, P., Rojsitthisak, P. (2017). Kinetic study of chitosan-alginate biopolymeric nanoparticles for the controlled release of curcumin diethyl disuccinate. Journal of Metals, Materials and Minerals, 27 (2), 17–22.
• 32. Mehravaran, N., Moghimi, H., Mortazavi, S. A. (2009). The influence of various mucoadhesive polymers on in vitro performance of the resulting artificial saliva pump spray formulations. Iranian Journal of Pharmaceutical Research, 8 (1), 3–13.
• 33. Lapum, J., Verkuyl, M., Garcia, W., St-Amant, O., Tan, A. (2018). Vital Sign Measurement Across the Lifespan, 1st Canadian edition, Springer, Toronto, p. 26.
• 34. Moore, R. J., Watts, J. T. F., Hood, J. A. A., Burritt, D. J. (1999). Intra-oral temperature variation over 24 hours. European Journal of Orthodontics, 21(3), 249–261.
• 35. Ban, E., Park, M., Jeong, S., Kwon, T., Kim, E. H., Jung, K., Kim, A. (2017). Poloxamer-based thermoreversible gel for topical delivery of emodin: Influence of P407 and P188 on solubility of emodin and its application in cellular activity screening. Molecules, 22 (2), 246.
• 36. Zhang, K., Shi, X., Lin, X., Yao, C., Shen, L., Feng, Y. (2015). Poloxamer-based in situ hydrogels for controlled delivery of hydrophilic macromolecules after intramuscular injection in rats. Drug Delivery, 22 (3), 375–382.
• 37. Inal, O., Yapar, E. A. (2013). Effect of mechanical properties on the release of meloxicam from poloxamer gel bases. Indian Journal of Pharmaceutical Sciences, 75 (6), 700–706.
• 38. Koffi, A. A., Agnely, F., Ponchel, G., Grossiord, J. L. (2006). Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine. European Journal of Pharmaceutical Sciences, 27 (4), 328–335.
• 39. Ibrahim, E. S. A., Ismail, S., Fetih, G., Shaaban, O., Hassanein, K., Abdellah, N. H. (2012). Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application. Acta Pharmaceutica, 62 (1), 59–70.
• 40. Tirnaksiz, F., Robinson, J. R. (2005). Rheological, mucoadhesive and release properties of Pluronic F-127 gel and Pluronic F-127/polycarbophil mixed gel systems. Pharmazie, 60 (7), 518-23.
• 41. Todica, M., Pop, C. V., Udrescu, L., Pop, M. (2010). Rheological behavior of some aqueous gels of carbopol with pharmaceutical applications. Chinese Physics Letters, 27 (1), 018301.
• 42. Rahimi, S., Natan, B. (2000). Numerical solution of the flow of power-law gel propellants in converging injectors. Propellants, Explosives, Pyrotechnics, 25 (4), 203-212.
• 43. Franzén, H. M., Draget, K. I., Langebäck, J., Nilsen-Nygaard, J. (2015). Characterization and properties of hydrogels made from neutral soluble chitosans. Polymers, 7, 373-389.
• 44. Liu, W.H., Yu, T.L., Lin, H.L. (2007). Shear thickening behavior of dilute poly(diallyl dimethyl ammonium chloride) aqueous solutions. Polymer, 48 (14), 4152–4165.
• 45. Jones, D. S., Woolfson, A. D., Djokic, J. (1996). Texture profile analysis of bioadhesive polymeric semisolids: Mechanical characterization and investigation of interactions between formulation components. Journal of Applied Polymer Science, 61 (12), 2229–2234.
• 46. Tan, Y. T. F., Peh, K. K., Al-Hanbali, O. (2000). Effect of carbopol and polyvinylpyrrolidone on the mechanical, rheological, and release properties of bioadhesive polyethylene glycol gels. AAPS PharmSciTech, 1 (3), E24.
• 47. Cevher, E., Sensoy, D., Taha, M. A. M., Araman, A. (2008). Effect of thiolated polymers to textural and mucoadhesive properties of vaginal gel formulations prepared with polycarbophil and chitosan. AAPS PharmSciTech, 9 (3), 953-65.
• 48. Sarkar, U., Raha, A., Mukherjee, P., Paul, M., Bagchi, A. (2018). Development and evaluation of Metronidazole containing topical gel using different gelling agents. Asian Journal of Pharmacy and Pharmacology, 4 (6), 785–789.
• 49. Zhang, Y., Huo, M., Zhou, J., Zou, A., Li, W., Yao, C., Xie, S. (2010). DDsolver: An add-in program for modeling and comparison of drug dissolution profiles. The AAPS Journal, 12 (3), 263–271.
• 50. Soares, P. I. P., Sousa, A. I., Silva, J. C., Ferreira, I. M. M., Novo, C. M. M., Borges, J. P. (2016). Chitosan-based nanoparticles as drug delivery systems for doxorubicin: Optimization and modelling. Carbohydrate Polymers, 147 304–312.
• 51. Wang, Y., Jiang, S., Wang, H., Bie, H. (2017). A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases. PLoS ONE, 12 (12), e0189478.
• 52. Parhi, R. Suresh, P. (2015). Alginate-poloxamer beads for controlled release of metoprolol succinate. Turkish Journal of Pharmaceutical Sciences, 12 (1), 59–66.
• 53. Mori, N. M., Patel, P., Sheth, N. R., Rathod, L. V., Ashara, K.C. (2017). Fabrication and characterization of film-forming voriconazole transdermal spray for the treatment of fungal infection. Bulletin of Faculty of Pharmacy, Cairo University, 55 (1), 41–51.