KOLON KANSERI HASTALARINDA İLAÇ ETKİLEŞİMLERİNİN YÖNETİMİ

Amaç: Kolon kanseri, dünya çapında en yaygın üçüncü kanser türüdür ve genellikle ileri yaşlarda ortaya çıkar. Yaşla birlikte komorbid hastalık riski de artabileceğinden, kolon kanseri hastalarının polifarmasi riski artmıştır. Hipertansiyon, kronik obstrüktif akciğer hastalığı, diyabet ve kardiyovasküler hastalık, kanser hastalarında sık görülen komorbiditelerdir. Yaşlı, komorbid rahatsızlıkları olan ve iki veya daha fazla ilaç alan hastalar, ilaç-ilaç etkileşimleri (İİE) için daha yüksek risk altındadır. Ayrıca kanser hastaları, sitotoksik ilaçların yan etkilerinin tedavisi için sıklıkla destekleyici bakım ilaçları gibi birçok ilacı kullanmaktadır. İİE'ler terapötik başarısızlığa veya potansiyel olarak ciddi yan etkilere neden olabilir. İİE düzeylerinin belirlenmesi ve değerlendirilmesi, kanser hastaları için en uygun akılcı tedavinin sağlanmasında yardımcı olmaktadır.

Anahtar Kelimeler:

ilaç-ilaç etkileşimleri, kolon kanseri, komorbidite, polifarmasi, yönetim

MANAGEMENT OF DRUG INTERACTIONS IN COLON CANCER PATIENTS

Objective: Colon cancer is the third most common cancer type globally and usually occurs at advanced ages. Since the risk of comorbid diseases may also increase with age, colon cancer patients have an increased risk of polypharmacy. Hypertension, chronic obstructive pulmonary disease, diabetes, and cardiovascular disease are the frequently seen comorbidities in cancer patients. Patients who are elderly, have comorbid conditions, and are taking two or more medications are at higher risk for drug-drug interactions (DDIs). Additionally, cancer patients frequently use many drugs such as supportive care drugs for the treatment of side effects of cytotoxic drugs. DDIs may cause therapeutic failure or potentially serious adverse events. determination and evaluation of DDI levels identify the most suitable rational therapy for cancer patients.

Keywords:

colon cancer, comorbidity, drug-drug interactions, management, polypharmacy,

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