Hayrettin SEÇİLMİŞ, Ebru ÇUBUK DEMİRALAY, Kader POTURCU

ASETONİTRİL-SU İKİLİ KARIŞIMLARINDA BAZI İMİDAZOL ANTİMİKOTİK İLAÇLARIN KROMATOGRAFİK PROTONASYON SABİTLERİNİN BELİRLENMESİ

Amaç: Bu çalışmada, antifungal azol türevi mikonazol ve tiokonazolün termodinamik protonasyon sabiti ((_s^s)〖pK〗_a ) ters faz sıvı kromatografisi (RPLC) yöntemi ile araştırılmıştır. Bu bileşiklerin RPLC yöntemi ile analizlerinde klasik sabit fazlar en yaygın olarak kullanılan kolon dolgulu malzemeler olmasına rağmen, siyano bazlı bir kolonla şimdiye kadar mikonazol ve tiokonazolün pKa değerinin tayini rapor edilmemiştir.

Anahtar Kelimeler:

Birleşik etki, İmidazol, Nonlineer regresyon, RPLC

DETERMINATION OF CHROMATOGRAPHIC PROTONATION CONSTANTS OF SOME IMIDAZOLE ANTIMYCOTIC DRUGS IN ACETONITRILE-WATER BINARY MIXTURES

Objective: In this study, the thermodynamic protonation constant ((_s^s)〖pK〗_a ) of antifungal azole derivative miconazole and tioconazole were investigated by the reversed-phase liquid chromatography (RPLC) method. Although classical stationary phases are the most commonly used column-packed materials in the analyses of these compounds by the RPLC method, the determination of the pKa value of miconazole and tioconazole with a cyano-based column has not been reported so far.

Keywords:

Combined effect, Imidazole, Nonlinear regression, RPLC,

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