Tip 2 Diyabetes Mellitus’ lu Hastalarda 25 Hidroksivitamin D Düzeyi ile HbA1c ve Vücut Kitle İndeksi Arasındaki İlişkisinin Değerlendirilmesi
Amaç:Diyabetes Mellitus’lu hastalarda 25-Hidroksivitamin D (25(OH)D) düzeyleri ile HbA1c, Vücut kitle indeksi (VKİ) arasındaki ilişkiyi araştırmaktır.Metod: Diyabetik hastalarda vitamin D düzeyleri ile birlikte HbA1c düzeylerine ve VKİ’ ne bakıldı. Aralarındaki ilişkiyi değerlendirmek için spearman korelasyon testi uygulandı.Sonuç: Vitamin D hipovitaminozu hastaların %78’ inde bulundu. Vitamin D düzeyleri ile HbA1c ve VKİ değerleri arasında anlamlı bir ilişkiye rastlanmadı.Tartışma: Vitamin D, DM ilişkisini araştırmak için geniş randomize kontrollü çalışmalara ihtiyaç vardır.
Evaluation of Serum 25-hydroxyvitamin D levels in the Patients With Type2 Diabetes Mellitus and Its Relationship with HbA1c and Body Mass Index
Aim: Aim of this study was to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) values and HbA1c and body mass index (BMI). Method: 25(OH)D, BMI and HbA1c values were evaluated in a diabetic population. Their relationship was evaluated with spearman corelation analysis. Results: Vitamin D hypovitaminosis was found in %78 of patients. There was not found a significant corelation between vitamin D and HbA1c, BMI values. Discussion: Large randomized controlled studies are needed to evaluate the relationship between DM and vitamin D.
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- 1. Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery
MA.Type 2 diabetes and oral antihyperglycemic drugs. Curr Med
Chem. 2008;15(1):61-74
- 2. Facchini FS, Hua N, Abbasi F, Reaven GM.. Insulin resistance as
a predictor of age-related diseases. J Clin Endocrinol Metab.
2001;86:3574–3578.
- 3. Glucose tolerance and mortality: comparison of WHO and
American Diabetes Association diagnostic criteria The DECODE
study group. European Diabetes Epidemiology Group. Diabetes
Epidemiology: Collaborative analysis Of Diagnostic criteria in
Europe. Lancet. 1999;354:617–621.
- 4. Satman İ. The update criteria and the reasons of them in
diagnosis and follow up of diabetes mellitus. Türkiye Klinikleri
Journal of Internal Medical Sciences 2007;3:1.15.
- 5. Tümer G, Çolak R. Tip 2 diabetes mellitusda tıbbi beslenme
tedavisi. J. Exp. Clin. Med., 2012; 29:S12-S15
- 6. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E: Serum
25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance
and diabetes mellitus. Diabetes Res Clin Pract 27:181–188, 1995
- 7. Scragg R, Sowers M, Bell C: Serum 25-hydroxyvitamin D,
diabetes, and ethnicity in the Third National Health and Nutrition
Examination Survey. Diabetes Care 27:2813–2818, 2004
- 8. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ (1995)
Glucose intolerance and impairment of insulin secretion in relation
to vitamin D deficiency in east London Asians. Diabetologia
38:1239–1245
- 9. Chiu KC, Chu A, Go VL, Saad MF (2004) Hypovitaminosis D is
associated with insulin resistance and beta cell dysfunction. Am
J Clin Nutr 79:820–825
- 10.Mathieu C, Gysemans C, Giulietti A, Bouillo R. Vitamin D and
diabetes. Diabetologia (2005) 48: 1247–1257
- 11.Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley
DA, Heaney RP, et al. Evaluation, treatment, and prevention of
vitamin D deficiency: an Endocrine Society clinical practice
guideline. J Clin Endocrinol Metab 2011;96: 1911-30.
- 12.Pilz S, van den Hurk K, Nijpels G, Stehouwer CDA. Vitamin D
status, incident diabetes and prospective changes in glucose
metabolism in older subjects: The Hoorn study. Nutrition,
Metabolism & Cardiovascular Diseases (2012) , 1-7
- 13.Zhao G, Ford ES, Li C. Associations of serum concentrations of
25-hydroxyvitamin
1. D and parathyroid hormone with surrogate markers of insulin
resistance among U.S. adults without physician-diagnosed
diabetes: NHANES, 2003–2006. Diabetes Care 2010; 33: 344–347.
- 14. Vilarrasa N, Vendrell J, Maravall J et al. Is plasma 25(OH) D related to
adipokines, inflammatory cytokines and insulin resistance in both a
healthy and morbidly obese population? Endocrine 2010; 38: 235–242.