Jülide ERGİL, İbrahim ÖZTÜRK, Murat SAYIN

PROPOFOL VE DEKSMEDETOMİDİN İLE SEDASYON VE SİSTEMİK İNFLAMATUAR YANIT SENDROMU

Propofol hızlı etki başlangıçlı, metabolizması karaciğer ya da böbrek yetmezliklerinden bağımsız olan, vücutta birikmeyen ve etkisi hızlı sonlanan bir intravenöz anesteziktir. Bu nedenle, ameliyathane dışı işlemlerde sedasyon için sıklıkla propofol tercih edilmektedir. Fakat propofol, özellikle postoperatif enfeksiyonlarla ilişkilidir. Bu nedenle enjektörün hazırlanması ve hastaya uygulanması sırasında asepsiye dikkat edilmesi gerekmektedir. 45 yaşında, 170 cm boy ve 78 kg ağırlığındaki erkek hastada, kolonoskopi sırasında 80 mg propofol ve 1 µg kg-1 deksmedetomidin ile sedasyon uygulandıktan sonra febril reaksiyon gözlendi. Bu makalemizde, febril reaksiyonun ayırıcı tanısını ve olası nedenlerini literatürü gözden geçirerek sunmayı amaçladık.

SEDATION WITH PROPOFOL AND DEXMEDETOMIDINE AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME

Propofol is an intravenous anesthetic which terminates rapidly, which does not accumulate in the body, whose metabolism is independent of liver or kidney failure, and which has a rapid onset. Therefore, propofol is generally prefered for sedation for the procedures out of the operating room, however, it is particularly associated with postoperative infections. For this reason, watching out for asepsi during the preparation of the injector and application of it to the patient is of utmost importance. Febrile reaction was observed after application of sedation with 80 mg propofol and 1 µg kg-1 dexmedetomidine during colonoscopy in a 45 years old, 170 cm height, 78 kg weighting patient, who had a physical status of American Society of Anestheisologist ASA I male. In this article, we aimed to present differentiate diagnosis of febrile reaction, and possible causes by reviewing the literature.

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