Gözde Bumin AYDIN, Reyhan POLAT, Emine ARIK, Jülide ERGİL, Birol TUNÇ, İbrahim ÖZTÜRK

TOTAL DİZ PROTEZİNDE PREEMPTİF DEKSKETOPROFEN TROMETAMOL VEYA PARASETAMOL/TRAMADOL KOMBİNASYONUN POSTOPERATİF ANALJEZİYE ETKİSİ

Amaç: Postoperatif ağrıda tramadol ve nonsteroid antiinflamatuvar ilaçların kullanımı sıktır. Bu randomize çift kör çalışmada deksketoprofen trometamol ile parasetamol/tramadol kombinasyonunun genel anestezi altında diz protezi olacak hastaların postoperatif 24 saatlik tramadol tüketimine, hastaların VAS değerlerine, ek analjezik ihtiyacına ve yan etki insidansı üzerine etkilerini değerlendirmeyi amaçladık. Metot: Etik kurul onamı alındıktan sonra ASA I-II grubu total diz protezi ameliyatı planlanan, 56 hasta çalışmaya alındı. Hastalar rastgele 28’er kişilik iki gruba ayrıldı. Grup A’ya deksketoprofen trometamol, Grup Z’ye parasetamol/tramadol kombinasyonu operasyondan 1 saat önce oral olarak verildi. Her iki gruba da standart genel anestezi yöntemi ve ekstübasyondan önce 1 mg kg-1 tramadol intravenöz uygulandı. Tüm hastalara tramadol HKA bağlandı. Hastaların 24 saatlik tramadol tüketimi, ek analjezik ihtiyacı varlığı, yan etkiler, VAS skorları, demografik verileri, cerrahi süresi kaydedildi. Bulgular: A grubuna göre Z grubunda medyan verilen bolus doz sayısı istatistiksel olarak anlamlı daha yüksekken (p=0.007), medyan istenilen bolus doz sayısı ise istatistiksel olarak anlamlı daha düşüktü (p=0.004). A grubuna göre Z grubunda ek analjezi ihtiyacı istatistiksel olarak anlamlı daha nadir ve daha geçti (p

PREEMPTIVE EFFECT OF DEXKETOPROPHEN TROMETAMOL OR PARACETAMOL/TRAMADOL COMBINATION ON POSTOPERATIVE ANALGESIA

Objective: The use of tramadol and non-steroidal anti-inflammatory drugs for postoperative pain is common. In this randomized, double blind study, we aimed to evaluate the analgesic efficacy of dexketoprophen trometamol and paracetamol/tramadol combination in 24 hour tramadol consumption of the patients, their VAS values, extra analgesic need, and side effects who undergo total knee prothesis under general anesthesia. Methods: After the approval of the Ethics Committee, the study was performed on 56 patients (ASA I-II) planned for total knee prothesis. The patients who were randomly allocated into two equal groups received oral dexketoprophen trometamol (Group A) or paracetamol/tramadol combination (Group Z), 1 hour before the operation. All patients received standard general anesthesia and received 1 mg kg-1 tramadol intravenously before extubation. All patients received patient controlled analgesia with tramadol, and their 24 hour tramadol consumption, VAS scores, extra analgesic need and side effects, demographic variables and duration of operation were recorded. Results: In group Z, median bolus doses of tramadol given was significantly high (p=0.007), but median attempt was significantly low (p=0.004). Additive analgesic need was statistically low and late in group Z (p

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