Evrim ÖZKORUMAK KARAGÜZEL, Demet SAĞLAM AYKUT, Pınar KIZILAY ÇANKAYA, MURAT KARKUCAK

Psikotik belirtiler gösteren bir osteogenezis imperfekta olgusu

Amaç: Osteogenezis imperfekta (Oİ) heterojon klinik bir durum olarak kabul edilmektedir. Genetik karmaşıklığı ve yaygın fenotipik değişkenliği bu durumun heterojen klinik görünümüne neden olur. Yöntem: Otuz üç yaşında, erkek hasta irritabilite, alınma düşünceleri ve agresif davranışlar nedeniyle konsülte edilmiştir. Sonuçlar: Fiziksel muayene ve radyolojik bulgularla Oİ tip-IV tanısı konulmuştur. Psikotik belirtiler düşük doz antipsikotik tedavi sonrası gerilemiştir. Tartışma: Bu yazıda psikotik belirtili nadir bir Oİ olgusu sunulmuştur. Pozitif aile öyküsü ile psikiyatrik bozukluk ve Oİ'nın birlikteliği psikotik bozuklukla Oİ arasındaki ortak genetik temele işaret edebilir.

A case of osteogenesis imperfecta presenting with psychotic symptoms

Objective: Osteogenesis imperfecta (OI) is regarded as a heterogeneous clinical condition. Genetic complexity and extensive phenotypic variation lead to heterogeneous clinical manifestations in the condition. Methods: A 33-year old, male underwent consultation because of irritability, reference ideas and aggressive behavior. Results: OI typeIV was diagnosed on the basis of physical examinations and radiological findings. Psychotic symptoms improved following low-dose antipsychotic treatment. Discussion: This report presents a rare case of OI with psychotic symptoms. Comorbidity of a psychiatric disorder and OI in a case with a positive family history for both may also emphasize a common genetic basis between the psychotic disorders and OI.

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