NERMİN GÜNDÜZ, Özge TİMUR, Erkal ERZİNCAN, Ümit TURAL

Panik bozukluğu hastalarında ortalama trombosit hacmi, nötrofil lenfosit oranı, platelet lenfosit oranı ve eritrosit dağılım genişliği

Amaç: Nötrofil lenfosit oranı (NLO) ve platelet lenfosit oranı (PLO) sistemik inflamatuar yanıtın değerlendirilmesinde yeni belirteçler olarak görülmektedir. Ortalama eritrosit dağılım genişliği (OEDG) kırmızı kan hücrelerinin boyut göstergesi olmakla birlikte, birçok hastalıkla ilişkili olabileceği gösterilmiştir. Ortalama trombosit hacmi (OTH) trombosit hacmini gösterir ve trombosit aktivitesinin potansiyel göstergesidir. Bu çalışmanın amacı, panik bozukluğu hastalarında günlük klinik uygulamada kolaylıkla elde edilebilen NLO, PLO, OTH ve OEDG gibi hematolojik değişkenlerin araştırılmasıdır. Yöntem: Çalışmaya DSM-5 tanı ölçütlerine göre panik bozukluğu tanısı konan 18-75 yaşları arasındaki 39 hasta alınmıştır. Kontrol grubunu yaş ve cinsiyet açısından benzer 40 sağlıklı kişi oluşturmuştur. Panik bozukluğu hasta grubuna klinisyen tarafından Hamilton Depresyon Ölçeği, Hamilton Anksiyete Ölçeği, Klinik Global İzlem Ölçeği ve Panik Bozukluğu Şiddeti Ölçeği uygulanmıştır. NLO, PLO, OEDG ve OTH hesaplanarak her katılımcı için kaydedilmiştir. Bulgular: Grupların sosyodemografik özellikleri arasında istatistiksel açıdan anlamlı bir fark bulunmamıştır. NLO, PLO, OEDG değerleri ile klinik ölçekler arasında istatistiksel olarak anlamlı farklılık olmadığı bulunmuştur. Bununla birlikte, OTH ile panik bozukluğu şiddeti arasında negatif korelasyon vardı. Sonuç: Bizim araştırmamız panik bozukluğu hastalarında NLO, PLO, OEDG ilişkisinin araştırıldığı ilk çalışma olma özelliğini taşımaktadır. Artmış sempatik aktivitenin OTH artışına neden olduğunu gösteren çalışmalar vardır. Çalışmamızda sağlıklı kontrol ve panik bozukluğu grubunda OTH değerleri açısından anlamlı bir farklılık olmadığı gözlendi. Bununla birlikte Panik Bozukluğu Şiddet Ölçeği ile OTH değeri arasında negatif korelasyon olması, panik bozukluğunun şiddeti arttıkça, OTH değerinin azalması lehine yorumlanmıştır.

The mean platelet volume, neutrophil lymphocyte ratio, platelet lymphocyte ratio and red cell distribution width in panic disorder

Objective: Assessment of the systemic inflammatory response of the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) is shown as a new biomarker. Red cell distribution width (RDW) is the size of red blood cells and have been found related to adverse events in many diseases. Mean platelet volume (MPV) indicates platelet volume and platelet volume is a potential indication of platelet activity. The aim of our study is to investigate hematological changes in patients with panic disorder (PD) through readily available markers such as NLR, PLR, RDW and MPV. Methods: Thirty-nine patients between the ages of 18 and 75 who were diagnosed with PD according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) and forty healthy control subjects were included in the study. MPV, NLR, PLR and RDW were measured and recorded for groups. Hamilton Depression Scale, Hamilton Anxiety Scale, Clinical Global Impressions Scale (CGI-S) and Panic Disorder Severity Scale were applied to the patients. Results: There were no statistically significant differences between groups in terms of sociodemographic characteristics. No significant correlation was found between NLR, PLR and RDW values and clinical scales. MPV was negatively correlated with the severity of panic disorder. There was no correlation between MPV and other variables. Conclusion: Our study is the first study to examine NLR, PLR and RDW associations in PD patients. There are studies showing that increased sympathetic activity leads to increased MPV. In our study, the MPV value did not differ between PD and control group. However, there was a negative correlation between the severity of panic disorder and MPV

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