SOD, CAT, TBARS, and TNF-α Concentrations in Uterine Tissues of Bitches with Pyometra and Dioestrus Bitches

Decreased antioxidant levels may be a cause of many diseases. Pus accumulation in the uterus literally called pyometra and generally occurs in median or late life span of bitches. The objective of the study was to evaluate the concentrations of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), oxidative stress parameter-thiobarbituric acid-reactive substances (TBARS) and inflammatory mediator, tumour necrosis factor alpha (TNF-α) in uterine tissues of bitches with and without pyometra. For this purpose, bitches with pyometra (n=27), and healthy bitches in dioestrus (n=8) included in the study and both of the groups went under ovariohysterectomy operation. SOD and CAT enzymes were found significantly higher in uterine tissues of dioestrus group (p

Pyometralı ve Sağlıklı Diöstrustaki Köpeklerde uterus SOD, CAT, TBARS ve TNF-α Konsantrasyonları

Azalmış antioksidan seviyeleri pek çok hastalığın sebebi olabilmektedir. Pyometra orta yaşlı ve yaşlı kısırlaştırılmamış dişi köpeklerde görülen uterusun irinle dolmasıyla karakterize bir hastalıktır. Çalışmamızın amacı oksidatif stres parametrelerinden süperoksit dizmutaz (SOD), katalaz (CAT), tiyobarbitürik asid maddeleri (TBARS) ve enflamatorik mediyatörlerden tümör nekroz faktörünün (TNF-alpha) pyometralı köpek uterusunda ve sağlıklı köpek uterusunda bakıp karşılaştırarak gruplar arasındaki olabilecek variyasyonu tespit etmekti. Bu amaçla, pyometralı köpekler (n=27) ve diöstrustaki sağlıklı köpekler (n=8) çalışmaya dahil edildi ve her iki gruptaki köpeklere de ovariyohisterektomi operasyonu uygulandı. Uterusta SOD ve CAT seviyeleri kontrol grubunda önemli oranda yüksek bulundu (sırasıyla, p

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