CEM ZEKİ ESENYEL, MEHMET SELAHATTİN DEMİRHAN, ÖNDER İSMET KILIÇOĞLU, Oktay ADANIR, Bilge BİLGİÇ, ÖZLEM GÜZEL, Serhat ÖZSOY

Üç değişik emilmeyen dikiş malzemesine karşı oluşan doku yanıtının tavşan modelinde incelenmesi

Amaç: Sık kullanılan üç emilmeyen dikiş malzemesinin dokuda oluşturduğu enﬂamatuvar yanıtlar tavşan modelinde değerlendirildi. Çalışma planı: Çalışmada, örgülü polyester (Ethibond), monoﬁlaman polipropilen (Polypropylene) ve örgülü polietilen ve polyester karışımı (FiberWire) dikiş malzemesi kullanıldı. Otuz altı adet tavşan, kullanılan dikiş materyaline göre, eşit sayıda üç gruba ayrıldı. Her bir dikiş malzemesi tavşanın her iki bacağındaki kuadriseps kasına, patellar tendona, diz eklem kapsülüne ve Aşil tendonuna uygulandı. Her gruptaki altışar tavşan üçüncü ve altıncı haftalarda öldürüldü. Dikiş malzemesinin oluşturduğu enﬂamatuvar yanıt ışık mikroskobu kullanılarak değerlendirildi ve enﬂamatuvar alanın genişliği ölçüldü. Sonuçlar: Üçüncü haftada kas ve tendonda en şiddetli enflamatuvar yanıtı Ethibond oluştururken, Ethibond’a bağlı yanıt altıncı haftada tüm dokularda en az düzeydeydi. Üçüncü haftada Propilen’in oluşturduğu yanıt orta düzeyde iken, altıncı haftada tüm dokularda en geniş enﬂamatuvar alana sahipti. Altıncı haftada kasta Propilen’in oluşturduğu enﬂamatuvar alan genişliği (6.6±2.1 mm) Ethibond’un oluşturdu- ğundan (1.6±0.9 mm) anlamlı derecede fazlaydı (p

Anahtar Kelimeler:

Eklem kapsülü, Tavşanlar, Süturlar, Yabancı cisim reaksiyonu, Modeller, hayvan, Polipropilen, Enflamasyon, Ameliyat sonrası komplikasyonlar

Evaluation of soft tissue reactions to three nonabsorbable suture materials in a rabbit model

Objectives: We evaluated the inﬂammatory reactions induced by three commonly used nonabsorbable suture materials in a rabbit model. Methods: Three suture materials were tested: braided polyester suture (Ethibond), braided blend of polyester and polyethylene suture (FiberWire), and monoﬁlament polypropylene suture (Polypropylene). Thirty-six rabbits were randomly allocated to three suture groups, equal in number. Each suture type was placed bilaterally in the quadriceps muscle, patellar tendon, knee joint capsule, and Achilles tendon. Six animals in each group were sacriﬁced in the third and sixth weeks. The inﬂammation induced by each suture was assessed using light microscopy and the width of the inﬂammation zone (WIZ) was measured. Results: Ethibond was found to cause the most severe reaction in the muscle and tendon in the third week; in the sixth week, however, it showed the lowest inﬂammatory reaction in all tissue types. Reaction to Propylene was moderate in the third week, whereas it caused the largest WIZ in all tissue types in the sixth week, such that the eventual size of the WIZ induced by Propylene (6.6±2.1 mm) was signiﬁcantly greater than that of Ethibond (1.6±0.9 mm) in muscle specimens (p<0.05). Except for the largest WIZ seen in joint capsule specimens in the third week, inﬂammatory reactions associated with FiberWire were low or moderate in all tissue specimens throughout the study. FiberWire was associated with some necrotic areas in two muscle and one tendon specimens. Conclusion: The extent of inﬂammatory reaction to nonabsorbable suture materials depends on the type of suture material, tissue type, and the duration of postoperative time.

Keywords:

Joint Capsule, Rabbits, Sutures, Foreign-Body Reaction, Models, Animal, Polypropylenes, Inflammation, Postoperative Complications,

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