NURETTİN AYDİLEK, CENGİZ CEYLAN, HÜDAİ İPEK, Ünsal GÜNDOĞDU

Effects of xylazine-diazepam-ketamine and xylazine-tiletamine-zolazepam anesthesia on some coagulation parameters in horses

Ksilazin-diazepam-ketamin (XDK) ve ksilazin-tiletamin-zolazepam (XTZ) kombinasyonları atların anestezi indüksiyonlarında yaygın bir şekilde kullanılmaktadır. Bu anestezik kombinasyonların atlardaki protrombin zamanı (PT), aktive edilmiş parsiyel tromboplastin zamanı (APTT) ve trombosit sayısı üzerindeki etkilerini araştıran herhangi bir çalışmaya rastlanamamıştır. Bunun için bu çalışmada, atlardaki koagulasyon parametreleri üzerinde XDK ve XTZ anestezik kombinasyonlardan hangisinin daha az etkili olduğunun araştırılması amaçlandı. Altı sağlıklı ata önce XDK, iki hafta sonra da XTZ kombinasyonu uygulandı. Anestezi öncesi ve anestezinin 10, 30, 60 ve 90. dakikalarında toplanan kan örneklerinde PT, APTT ve trombosit sayıları tespit edildi. PT ve APTT değerlerinde her iki grupta dalgalanmalar görülse de bunların atlar için normal referans değerler içinde kaldığı gözlendi. XTZ grubundaki trombosit sayısının 10. dakikada azaldıktan sonra 60. dakikada arttığı görüldü. XDK grubundaki trombosit sayısının ise sadece 10. dakikada azaldığı belirlendi. XDK ve XTZ grupları karşılaştırıldığında PT, APTT ve trombosit sayıları arasında fark olmadığı tespit edildi. Sonuç olarak, her iki anestezik kombinasyon koagulasyon parametrelerinde dalgalanmalara neden olsa da, bunun hemostazisi önemli bir şekilde etkilemediği görüldü. Bu anestezik kombinasyonların PT, APTT ve trombosit sayısı üzerindeki etkilerin klinik olarak önemli olmadığı, bundan dolayı koagülasyon bozukluğu olan atlarda güvenle kullanılabileceği sonucuna varıldı.

Anahtar Kelimeler:

kan pıhtılaşması, kan pıhtılaşma faktörleri, tromboplastin, at, ksilazin, anestetikler, diyazepam, ketamin

Ksilazin-diazepam-ketamin ve ksilazin-tilatamin-zolazepam anestezisinin atlarda bazı koagülasyon parametrelerine etkisi

Xylazine-diazepam-ketamine (XDK) and xylazine-tiletamine-zolazepam (XTZ) have been always used for induction of anesthesia. There is no report regarding the effects of these anesthetics on the activated partial thromboplastin time (APTT), prothrombin time (PT) and platelet count (PLT) in horse. Therefore, this study has been conducted to search for the anesthetic combination less affecting the coagulation parameters in horses. Six healthy, mixed breed horses received XDK and XTZ anesthetic combinations at two weeks interval. Blood samples were collected before (baseline) and at 10, 30, 60 and 90 min after anesthesia and APTT, PT and PLT were measured. Although it was observed fluctuations in PT and APTT in both groups, it always remained within normal reference values of horse. In the XTZ group PLT decreased at 10 min, and increased at 60 min. On the other hand, PLT increased only at 10 min in the XDK group. There are no significant differences in PT, APTT and PLT values between groups. In conclusion, both anesthetics administration caused a fluctuation in the coagulation parameters. The small changes in these parameters are probably not clinically relevant, therefore these combinations can be used safely even in horses with coagulation disorders.

Keywords:

blood coagulation, blood coagulation factors, thromboplastin, horses, xylazine, anaesthetics, diazepam, ketamine,

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