Farmasötik Uygulama İçin Halymenia durvillei Bory 1828'in Biyoaktif Özellikleri: Antioksidan, Antidiyabetik, Kırışıklık Önleyici ve Cilt Beyazlatıcı Aktiviteler

Deniz yosunları, çeşitli sağlık yararları sağlayan biyoaktif bileşiklerin bilinen kaynaklarıdır. Bununla birlikte, Halymenia durvillei gibi ekonomik açıdan önemli bazı deniz yosunlarının potansiyel farmasötik uygulamalarına ilişkin bilgiler hala sınırlıdır. Bu çalışmada H. durvillei'nin biyoaktif özellikleri incelenmiştir. Sonuçlar, makroalganın 6.77 ± 0.03 mg GAE/g toplam fenolik içerik (TPC) içerdiğini gösterdi. H. durvillei'nin antioksidan aktivitesi, sırasıyla 106 μg GAE/mL ve 20.44 μg GAE/mL IC50 değeri ile güçlü ABTS+ radikal süpürme aktivitesi ve yüksek bakır indirgeme kapasitesi sergiledi. H. durvillei ekstraktının tirozinaz ve elastaz inhibisyon özelliklerinin in vitro değerlendirmesi, alg'in IC50'si 40 μg GAE/mL ve IC50'si 696 μg GAE/mL 'lik güçlü inhibitör aktiviteye sahip olduğunu ve kojik asit ve tokoferolden daha etkili olduğunu gösterdi. Ek olarak, -amilaz inhibisyon özelliklerinin değerlendirilmesi, H. durvillei ekstraktının IC50 değeri 56 μg GAE/mL olan güçlü inhibitör aktiviteye sahip olduğunu ve IC50 değeri 101 μg/mL olan akarbozdan (standart anti-diyabetik ilaç) daha etkili olduğunu göstermiştir. Mevcut araştırma, yeni ilaçların sentezi için kullanılabilen farmasötik uygulama için H. durvillei'nin potansiyelini göstermektedir.

Anahtar Kelimeler:

Biyolojik aktivite, Kimyasal bileşim, Deniz, Filipinler, Yosunlar

Bioactive Properties of Halymenia durvillei Bory 1828 for Pharmaceutical Application: Antioxidant, Antidiabetic, Antiwrinkling and Skin-Whitening Activities

Seaweeds are known sources of bioactive compounds that provide diverse health benefits. However, knowledge on the potential pharmaceutical application of some economically important seaweeds such as Halymenia durvillei is still limited. In this study, the bioactive properties of H. durvillei were studied. The results showed that the macroalga contains a total phenolic content (TPC) of 6.77 ± 0.03 mg GAE/g. Antioxidant activity of H. durvillei exhibited potent ABTS+ radical scavenging activity and high copper reduction capacity with IC50 value of 106 μg GAE/mL and 20.44 μg GAE/mL, respectively. In vitro assessment of tyrosinase and elastase inhibition properties of H. durvillei extract showed that the alga has potent inhibitory activity with IC50 of 40 μg GAE/mL and IC50 of 696 μg GAE/mL, respectively more effective than kojic acid and tocopherol. In addition, evaluation of -amylase inhibition properties showed that H. durvillei extract has potent inhibitory activity with IC50 value of 56 μg GAE/mL more effective than acarbose (standard anti-diabetic drug) with IC50 of 101 μg/mL. The current investigation shows the potential of H. durvillei for the pharmaceutical application, which can be utilized for the synthesis of novel drugs.

Keywords:

Biological Activity, Chemical composition, Marine, Philippines, Seaweeds,

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