Prostat taşları serum prostat spesifik antijen seviyesini artırır mı?

Bu çalışmada prostat taşlarının serum PSA düzeyini artırıp attırmadığı araştırılmıştır. Temmuz 2004 ile Mart 2005 tarihleri arasında transrektal ultrasonografi (TRUS) klavuzluğunda prostat biyopsisi yapılan ve benign prostat hiperplazisi (BPH) tanısı alan 110 hasta çalışmaya alınmıştır. Tüm hastaların serum PSA düzeyleri, parmakla rektal muayene (PRM) bulguları ve TRUS ile yapılan değerlendirmeden elde edilen prostat volümü ve prostat taşlan açısından değerlendirilmeleri kaydedildi. Hastalar PSA düzeyileri 20 ng/ml'nin üzerinde olanlar, 10-20 ng/ml arasında olanlar ve 10 ng/ml'nin altında olanlar şeklinde üç gruba ayrılarak değerlendirildiler. Yüz on hastanın 61'inde (%55.4) prostat taşı saptandı. Prostat taşı bulunması ile serum PSA düzeyleri arasında anlamlı bir ilişki gözlenmedi (p=0.3). Serum TPSA düzeyleri ile total ve transizyonel prostat hacmi arasında korelasyon gözlenmedi (r=0.05, r=0.02). 70 hastada (%63.6) TRUS'de heterojen eko özellikleri mevcuttu ve TRUS bulguları ile prostat taşı görülmesi arasında pozitif korelasyon saptandı (p=0.02). Prostat taşlarının serum PSA düzeylerini ve prostat hacmini etkilemediği gösterilmiştir. Total PSA düzeyleri ile,prostatın total ve transizyonel bölge hacmi arasında da korelasyon gözlenmemiştir.

Do the prostatic calculi cause high level of prostate-specific antigen?

We investigated whether the prostatic calculi might influence serum PSA level. Between July 2004 and March 2005, 110 patients who underwent sextant core transrectal ultrasound (TRUS) guided prostate biopsy and diagnosed as benign prostatic hyperplasia (BPH) were included. PSA serum level determination, digital rectal examination, prostate volume measurements and prostatic calculi detection by TRUS were done for all patients. The patients were divided according to their PSA values into three groups, PSA > 20 ng/ml, PSA 10-20 ng/ml and PSA < 10 ng /ml, respectively and evaluated separately. Prostatic calculi were detected in 61 of 110 patients (55.4%). There was no significant association between the presence of prostate calculi and PSA serum level (p = 0.3). There was no correlation between TPSA serum values and total or transition volume of prostate (r = 0. 05, r = 0.02). The heterogeneous echo-pattern findings at TRUS were found in 70 patients (63.6%) and there was positive correlation between the findings of TRUS and the presence of the prostatic calculi (p = 0.02). The presence of prostatic calculi does not influence the serum PSA level nor the prostate volume. There was no correlation between total PSA and total and transition zone volume of the prostate.

Kaynakça

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