Diyabetes mellitus regülasyonunun osteoporoz ile ilişkisi

Amaç: Bu çalışmada diyabetin regülasyonu ile kemik mineral dansitesi (KMD) arasında farklılık olup olmadığı-nın araştırılması amaçlanmıştır. Materyal ve Metot: Prospektif olarak yapılan çalışmaya 30 iyi kontrollü diyabet (HbA1c ≤%6,5), 30 iyi kontrollü olmayan diyabet (HbA1c>%6,5) ve 30 diyabeti olmayan, toplam 90 postmenopozal kadın hasta dahil edildi. Erken menopoza girenler, KMD üzerine etki edecek ilaç kulla-nanlar, kemik metabolizmasını etkileyen hastalığı olanlar, alkolizm, osteoporotik kırık hikayesi olanlar, osteoporoz tedavisi alanlar çalışmadan dışlandı. Tüm hastaların antropometrik ölçümleri yapıldı. Serum açlık glukozu, HbA1c düzeyi, lumbal vertebra ve proksimal femur bölgelerinden KMD ölçümü yapıldı. Bulgular: Diyabetin regülasyonu ile beden kitle indeksi, bel çevresi, bel boy oranı, vücut yağ indeksi arasında farklılık saptanmadı (p=0,84, 0,28, 0,64, 0,59). HbA1c kötü kontrollü diyabet grubunda anlamlı olarak yüksek bulundu (p=0,001). Diyabet ile osteoporoz arasında ve diyabetin regülasyonu ile osteoporoz arasında ilişki saptanmadı (p>0,05). Beden kitle indeksi (BKİ) 40 kg/m2’nin üzerinde olanlarda femur T ve femur Z skorları yüksek saptandı (p=0,04, 0,01). Sonuç: Diyabette kötü glisemik kontrol diğer organlar-daki kronik komplikasyonları hızlandırırken, bu çalışma-da, KMD değerleri ile HbA1c arasında korelasyon saptanmadı.

Anahtar Kelimeler:

Osteoporoz, Hemoglobin A, glikozillenmiş, Vücut kitle indeksi, İleriye dönük çalışma, Diabetes mellitus

The relationship between diabetes mellitus regulation and osteoporosis

Aim: In this study, we aimed to investigate whether there is a difference between diabetes regulation and bone mineral density (BMD). Material-Method: In this prospective study 30 well-controlled diabetes (HbA1c≤%6.5), 30 not well controlled diabetes (HbA1c>%6.5) and 30 cases without diabetes, totaly 90 postmenopausal women were included. Entrance to early menopause, with drug use that will impact on BMD, those illnesses that affect bone metabo-lism, alcoholism, those with history of osteoporotic fracture and patients receiving the treatment of osteoporosis were excluded from the study. All patients' anthropometric measurements were performed. Serum fasting glucose, HbA1c levels, BMD were measured in lumbar spine and proximal femur regions. Results: There was no significant differences between diabetes regulation and body mass index, waist circumference, waist/height ratio, body fat index (p= 0.84, 0.28, 0.64, 0.59). There was no relationship between the presence of diabetes and osteoporosis and diabetes regulation and osteoporosis (p>0.05). T and Z scores on femur were higher in the patients who had BMI over 40 kg/m2 (p=0.04, 0.01). Conclusion:, While poor glycemic control accelerating the chronic complications of diabetes on other organs, this study could not detect a correlation between BMD values and HbA1c.

Keywords:

Osteoporosis, Hemoglobin A, Glycosylated, Body Mass Index, Prospective Studies, Diabetes Mellitus,

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