POLİSİTEMİ
Polisitemi eritrositozis , eritrosit sayısı, hematokrit değer ve hemoglobin konsantrasyonunda artışla karekterize olan patolojik bir durumdur Polisitemi, absolut ve relatif polisitemi olarak; absolut polisitemi de primer polisitemia rubra vera ve sekunder uygun, uygunsuz olarak ikiye ayrılmaktadır. Eritropoietin seviyesi polisitemilerin ayırıcı teşhislerinde klinik olarak çok önemlidir. Eritropoietin seviyesi P. vera'da düşük, sekunder eritrositoziste yüksektir. Sekunder polisitemili hastalarda çoğunlukla idrar veya plazma ya da her ikisinde de Eritropoietin konsantrasyonu artmıştır. Bu derlemede, polisitemilerin sınıflandırılması, teşhis yöntemleri ve tedavi olanakları hakkında bilgiler verilerek, karşılaşılan şüpheli vakaların detaylı incelenmesinde yardımcı olabilecek bilgileri aktarmak amaçlanmıştır
POLYCYTHEMİA
Polycythemia erythrocytsis is a State characterizid by an elevated erythrocyte mass, hematocrit value and hemoglobin concentration. Polycythemia may be relative or absolute. Absolute polycythemia can be primary polycythemia rubra vera or secondary appropriate or inappropriate . Erythropoietin level is very important for differential diagnosis of polycythemia. Erythropoietin level is decreased in polycythemia vera and elevated in seconder erythrocytosis. Erythropoietin concentration is elevated in urine or plasma or either in patient with seconder polycythemia. In this review, it has been given some information about the classifıcation, diagnosis and treatment of polycythemia. It is aimed to give some Information that could heplful in detailed examination of suspected cases
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- 1- Giger U: Erythropoietin and its Clinical Use, Comp.
ContinuingEducationArticle, 14(1),25-34, (1992).
- 2- Jain NC: In:Essential of veterinary hematology, LeaFebiger, Philadelphia, (1993).
- 3- Golde DW, Hocking WG, Koeffler HP, Adamson JW:
Polycythemia: Mechanisms and Management. Ann. Inter.
Med., 95,71-87, (1981).
- 4- Gilbert HS: Definition, clinical features and diagnosis of
the poltcythemia States. Ann. Clin. Lab. Sci. 10:311-
319,(1975).
- 5- Peterson ME, Randolf JF: Diagnosis of canine primary
polycythemia and management with hydroxyurea. J. Am.
Vet. Med. Assoc. 180 (4): 415-418, (1982).
- 6- Wintrobe MM: Clinical Hematology. Philadelphia:LeaFebiger, 690, (1981).
- 7- Graber SE, Krantz SB: Erythropoietin: Biology and
clinical use. Hematol Oncol Clin North Am, 3:369, (1989).
- 8- DiBartola SP, Rutgers HC, Zack PM, Tarr MJ:
Clinicopathologic findings assosiated with cronic renal
disease in cats: 74 cases JAWMA 190: 1196-1202, (1987).
- 9- Campbell KL: Diagnosis and management of
polycythemia in dogs. Compend. Contin. Educ. Pract.
Vet.l2(4):543-550, (1990).
- 10- Koeffler MP, Goldwasser E: Erythropoietin
radioimmunoassay in evaluating in polycythemia. Ann.
Intem. Med. 94:44-47,(1981).
- 11- Birgegard G et al: Serum erythropoietin levels by
radioimmunoassay in polycythemia. Scand. J. Heamatol.
29:161 -165, (1982).
- 12- Foster ES and Lothrop CD: Polycythemia vera in a cat
with cardiac hypertrophy. J. Am. Vet. Med. Assoc.
192:1736,(1988).
- 13- Walker BR, Resta TC, Nelin LD: Nitric oxide-dependent
pulmonary vasodilation in polycythemic rats. Am J
PhysiolHeart Circ Physiol, 297(5): H2382-9, (2000).
- 14- Frisbee JC, Murrant CL, Wilson BA, Barklay JK:
Polycythemia decreases fatigue in tetanic constractions of
skeletal muscle. Med Sci Sports Exerc, 31(9): 1293-
1298,(1999).
- 15- Wagner KF, Katschinski DM, Hasegawa J, Schumacher
D, Meller B, Gembruch U, Schramm U, Jelkmann W,
Gassmann M, Fandrey J: Chronic inborn erythrocytosis
leads to cardiac dysfunction and prematüre death in mice
overexpressmg erythropoietin. Blood, 97(2):536-
542„(2001).
- 16- Erslev AJ and Caro J: Pathophysiology and classifıcation
of polycythaemia. Scand. J. Haematol., 31, 287-292,
(1983).
- 17- Heimpel H: The present State of pathophysiology and
therapeutic trials in polycythemia vera. Int. J Hematol,
64(3-4):153-165,(1996).
- 18- Peterson ME and Randolf JF: Diagnosis and treatment of
polycythemia. In: Kirk RW, ed. Current veterinary teraphy
VIII. Philadelphia: WB Saunders Co, 406-408, (1983).
- 19- Bunn HF: Erythropoietin: Current Status, The Yale Journal
of Biology andMedicine, 63,381-386, (1990).
- 20 Erslev AJ: Erythropoietin, The New England Journal of
Medicine, 324 (19), 1339-1344, (1991).
- 21- Popovic WJ, Adamson JW: Erythropoietin assay: present
status of methods, pitfalls, and results in polycythemic
disorders. CRC Crit. Rev. Clin. Lab. Sci. 10: 57-87,
(1979).
- 22- Rosenthal A, Marsh S, Manor D, et al: DNA synthesis by
erythroid precursors in a completely defined medium: a
rapid, sensitive, and convenient bioassay for
erythropoietin. Exp. Hematol. 13:174-184,(1985).
- 23- Jacobson LO, Goldwasser E, Fried W, Plzak L. Role of the
kidney inerythropoiesis.Nature. 179:633-634,(1957).
- 24- Thorling EB: Paraneoplastic erythrocytosis and
inappropriate erythropoietin production: a review. Scaııd.
J.Haematol. 17(Suppl. 17): 1-166,(1972).
- 25- Adamson JW: Familial polycythemia. Semin. Hematol.
12:383-396,(1975).
- 26- Greenberg BR, Golde DW: Eıythropoiesis in familial
erythrocytosis. N. Engl. J. Med. 296: 1080-1084, (1972).
- 27- Abildgaard CF, Comet J, Schulman I: Prymary
erythrocytosis. J. Pediatr. 63:1072-1080, (1973).
- 28- Berlin NI: Diagnosis and classifîcation of the polycthemia
States. Semin. Hematol. 12:339-351, (1975).
- 29- Brodsky I: The differential diagnosis of the polycythemia
States. Ann. Clin. Lab. Sci. 10:311-319, (1980).
- 30- Couto CG, Boudrieau RJ and Zanjani ED: Tumorassociated erythrocytosis in a dog with nasal fibrosarcoma.
J. Vet. Int. Med., 3,183-185, (1989).
- 31- Peterson ME, Zanjani ED: inappropriate erythropoietin
production from a renal carcinoma in a dog with
polycythemia. J. Am. Vet. Med. Assoc. 179: 995-996,
(1981).
- 32- Görse MJ: Polycythemia associated with renal
fibrosarcomain a dog. J. Am. Vet. Med. Assoc. 192:793,
(1988).
- 33- Harvey JW: Myeloproliferative disorders in dogs and
cats. Vet. Clin. North. Am. (Small Anim. Pract.) 11:349-
381,(1981).
- 34- Petrites-Murphy MB, Kenneth R. Pierce, Fisher JW: Effect
of incorporation of serum from dogs with renal impairment
on canine erythroid bone marrow cultures. Am. J. Vet.
Res. 50 (9); 153 7-1543,(1989).
- 35- Eschbach JW, Kelly MR, Haley NR et al: Treatment of
anemia of Progressive renal failure with recombinant
human erythropoietin N. Eng. J. Med. 321:158-163,
(1989).
- 36- Nelson RW, Hager D, Zanjani ED: Renal lymphosarcoma
with inappropriate erythropoietin production in a dog.
JAVMA, 182:1396-1397, (1983).
- 37- Codner EC: Transient Erythrocytosis (Primary
Polycytaemia) in a Dog. Com. Haematol. Int, 2, 111-
113,(1992).
- 38- Lennox TJ, Wilson JH, Ilayden DW, Bouljihad M, Sage
AM, Walser MM, Manivel JC: Hepatoblastoma with
erythrocytosis in a young female horse. J Am Vet Med
Assoc, 216(5):718-721, (2000).
- 39- Turgut K: Veteriner klinik laboratuvar teşhis. 2. baskı,
Bölüm 2; 17-78, Bahçıvanlar basım sanayi A.Ş, (2000).
- 40- Kirk RW, Bistner Sİ, Ford RB: Handbook of Veterinary
Procedures and Emergency Treatmenr., 5th Ed., 664- 665,
WB Sauııders Company, (1990).
- 41- Caro J and Erslev AJ: Erythropoietin assays and their use
in the study of anemias. Contrib. Nephrol. 66:54, (1988).
- 42- Dunn CDR, Lange RD: Erythropoietin: assay and
characterization; in Roaths, Topical reviews in
hematology, pp: 1-32 (Wright, Bristol), (1979).
- 43- Chandler EA, Thompson DJ, Sutton JB, Price CJ: Canine
medicine and therapetics, 3rd Ed., Chapter 11:417-448;
Chapter 23:771 -808. Blackwell Science, (1995).
- 44- Hoffman R and Wasserman LR: Natura! history and
management of polycythemia vera. Adv. Intem. Med.,
24:255-285,(1979).
- 45- Barragry TB: Veterinary Drug Therapy Chapter 36: 919-
940. Lea-Febıger, USA, (1994).