Günay EKBERLİ, Tanju AKTUĞ, Hüseyin DİNDAR, Emin AYDIN YAĞMURLU, Meltem BİNGÖL KOLOĞLU, Ahmet Murat ÇAKMAK, Gülnur GÖLLÜ, Nil YAŞAM TAŞTEKİN, Ufuk ATES, Anar QURBANOV

Objective: Hypospadias is a common genitourinary system (GUS) anomaly in boys occurring in 1 of 200 to 300 live births. Undescended testes is frequently detected among accompanying anomalies in cases with hypospadias. Especially in proximal hypospadi

Amaç: Hipospadias erkek çocuklarda 200-300 canlı doğumda bir görülen genitoüriner sistem (GÜS) anomalisidir. Hipospadias olgularına eşlik eden anomaliler arasında inmemiş testis saptanması sıktır. Özellikle proksimal hipospadias ve bilateral inmemiş testis birlikteliği cinsel farklılaşma bozukluklarına işaret edebilir. Bu çalışmada inmemiş testisin eşlik ettiği hipospadiaslı çocuklarda ek anomalilerin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: 2007-2016 yılları arasında hipospadias nedeniyle ameliyat olan 392 çocuğun verileri geriye dönük olarak tarandı. Bunlardan 65 (%16.6) olguda meatus skrotal ve penoskrotal, 327’sinde (%83.4) glanüler, koronal, subkoronal ve midpenil yerleşimliydi. Olgular her iki testisi yerinde olan ve olmayanlar olarak ayrıldı ve ek anomaliler kaydedildi. Bulgular: Proksimal hipospadiaslı çocukların ortanca yaşı 21 ay (6-240 ay)’dı. Proksimal hipospadiaslı çocuklardan 26’sının (%40) inmemiş testisi mevcutken, 39 (%60) olguda testisler skrotumda ele geldi. İnmemiş testisi olan gruptaki hastaların 17’sinde bilateral (%65.4), dokuzunda tek taraflı (%34.6) inmemiş testis saptandı. İnmemiş testisi olan grupta 24 hastada (%92.3) fizik muayenede kuşkulu dış genitalya (bifid skrotum, penoskrotal transpoziyon, mikropenis ve penoskrotal hipospadias beraberliği, skrotalize labium majus) mevcuttu. İnmemiş testisi olan grupta üç hastada (%11.5) ek üriner anomali, on hastada (%38.5) ise diğer sistem anomalilerinin eşlik ettiği saptandı. Her iki testisin ele geldiği proksimal hipospadias hasta grubunda 10 hastada ( %25.5) kuşkulu dış genitalya mevcuttu. Her iki testisi skrotumda ele gelen 39 hastanın birinde (%2.5) ek üriner patoloji, beşinde (%12.8) ise diğer sistem anomalilerine rastlandı. Distal hipospadiaslı çocukların ortanca yaşı 33 ay (6-156 ay)’dı. Distal hipospadiaslı 327 çocuğun 9’unda (%2.8) inmemiş testis mevcuttu. Bunlardan beşinde bilateral (%55.6), 4’ünde tek taraflı (%44.4) inmemiş testis izlendi. Distal hipospadiası olan hastaların hiç birinde (%0) fizik muayenede kuşkulu genitalya saptanmadı. İnmemiş testisi olan grupta bir hastada (%11.1) ek üriner patoloji, bir hastada (%11.1) ise diğer sistem anomalilerinin eşlik ettiği saptandı. Her iki testisi skrotumda ele gelen yedi hastada (%2.2) ek üriner patoloji, 32 hastada (%9.8) ise diğer sistem anomalilerine rastlandı. Sonuç: Sonuçlarımıza dayanarak inmemiş testisin eşlik ettiği proksimal hipospadiaslı olgularda ürogenital sisteme yönelik ultrasonografi, gerektiğinde pelvik MRG, endokrinolojik analiz, genetik inceleme gibi ileri tetkik gerekliliğinin akılda tutulması gerektiği, tüm hipospadiaslı çocuklarda ek anomaliler açısından tüm sistemleri içeren ayrıntılı anamnez ve fizik muayene ile tetkik edilmesi gerektiği kanısındayız.

Evaluation of Additional Anomalies in Concomitance of Hypospadias and Undescended Testes

Objective: Hypospadias is a common genitourinary system (GUS) anomaly in boys occurring in 1 of 200 to 300live births. Undescended testes is frequently detected among accompanying anomalies in cases with hypospadias.Especially in proximal hypospadias and bilateral cases, this association may indicate sexual differentiation disorders. Theaim of the study was to evaluate the togetherness of additional anomalies in hypospadiac children with undescendedtestes.Material and Methods: Between 2007 and 2016, data of 392 children who underwent surgery for hypospadias wereevaluated retrospectively. Urethral meatus was present at scrotal and penoscrotal in 65 cases (16.6%) and glanular,coronal, subcoronal and midpenile in 327 cases (83.4%). The cases were divided into two groups as those with bothtestes in the scrotum and those with undescended testes, and the anomalies were recorded.Results: The mean age of the children with proximal hypospadias was 21 months (6-240 months). Of the childrenwith proximal hypospadias, 26 (40%) had undescended testes and 39 (60%) had testes in the scrotum. Undescendedtestes were detected bilaterally in 17 patients (65.4%) and unilaterally in nine patients (34.6%) in the undescendedtestes group. In the undescended testes group, 24 patients (92.3%) had suspected external genitalia (bifid scrotum,penoscrotal transposition, togetherness of micropenis and penoscrotal hypospadias, scrotalized labium majus) onphysical examination. In the undescended testes group, three patients (11.5%) had additional urinary pathology andten patients (38.5%) had other system anomalies. Ten patients (25.5%) had suspicious external genitalia on physicalexamination in the proximal hypospadias group who had both testes in scrotum. Additional urinary pathology wasdetected in one patient (2.5%) while other system anomalies were detected in five (12.8%) patients.The mean age of children with distal hypospadias was 33 months (6-156 months). Nine of 327 children with distalhypospadias (2.8%) had undescended testes. Of these, five were bilateral (55.6%) and 4 had unilateral undescendedtestes (44.4%). None of the patients with distal hypospadias had any suspicious genitalia on physical examination. Inthe undescended testes group, one patient (11.1%) had additional urinary pathology and one patient had other systemanomaly. Seven patients (2.2%) who had both testes in scrotum had additional urinary pathology and 32 patients (9.8%)had other system anomalies.

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