Mast cell typing in aortic onchocerciasis and the immunohistochemicaldemonstration of Wo l b a c h i a bacteria

Mast cell typing in aortic onchocerciasis and the immunohistochemicaldemonstration of Wo l b a c h i a bacteria

In this study, the presence of endosymbiotic Wolbachia bacteria was determined by immunohistochemical methods in 8 out of 43 paraffin-embedded bovine aortic tissues that were macroscopically and microscopically diagnosed with aortic onchocerciasis in the archive of the Harran University Faculty of Veterinary Medicine s Department of Pathology. By means of the enzyme histochemical and immunohistochemical staining methods, it was ascertained that the tryptase-containing subtype of mast cells (MCT) was involved in the inflammatory response in the bovine aortae with onchocerciasis. The aim of this study was to elucidate the pathogenesis of aortic onchocerciasis lesions caused by Onchocerca armillata in Turkey and to demonstrate the presence of endosymbiotic Wolbachia bacteria in these lesions.

___

  • 1. Neary JM, Trees AJ, Ekale DD, Tanya VN, Hetzel U, Makepeace BL. O. armillata contains the endosymbiotic bacterium Wolbachia and elicits a limited inflammatory response. Vet Parasitol2010; 174: 267–276.
  • 2.Cheema AH, Ivoghli B. Bovine onchocerciasis caused by O. armillata and O. gutturosa. Vet Pathol1978; 15: 495–505.
  • 3. Ogundipe GA, Ogunrinade AF, Akpavie SO. The prevalence, gross lesions and histopathology of aortic onchocerciasis in Nigerian cattle. Vet Q 1984; 6: 85–89.
  • 4.Ozyildiz Z, Yilmaz R, Ozsoy SY, Ozkul IA. Parasitic aortitis due to Onchocerca armillata in slaughtered cattle in the southeastern region of Turkey. Kafkas Univ Vet Fak Derg 2013; 19: 589–594.
  • 5. Alibaşoğlu M, Göksu K, Ertürk E, Güler S. Türkiyede sığılarda görülen onchocerciasis olayları (Onchocerca armillata Raillet ve Henry 1909). Ankara Üniv Vet Fak Derg 1969; 16:50–60 (in Turkish).
  • 6. Mather C, Treuting P. O. armillata contamination of a bovine pericardial xenograft in a human patient with repaired tetralogy of Fallot. Cardiovasc Pathol2012; 21: 35–38.
  • 7. Wildenburg G, Kromer M, Buttner DW.Dependence of eosinophil granulocyte infiltration into nodules on the presence of microfilariae producing O. volvulus. Parasitol Res1996; 82:117–124.
  • 8. Mtei BJ, Sangha HJN. Aortic onchocercosis and elaeophorosis in traditional TSZ-cattle in Tabora (Tanzania): prevalence and pathology. Vet Parasitol 1990; 36: 165–170.
  • 9. Specht S, Brattig N, Buttner M, Buttner DW. Criteria for the differentiation between young and old O. volvulus filariae. Parasitol Res 2009; 105: 1531–1538.
  • 10. Casiraghi M, McCall JW, Simoncini L, Kramer LH, Sacchi L, Genchi C, Werren JH, Bandi C. Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes? Int J Parasitol2002;32: 1457–1468.
  • 11. Langworthy NG, Renz A, Mackenstedt U, Henkle-Dührsen K, de Bronsvoort MB, Tanya VN, Donnelly MJ, Trees AJ. Macrofilaricidal activity of tetracycline against the filarial nematode O. ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship.Proc R Soc Lond BBio 2000; 267: 1063–1069.
  • 12. Gilbert J, Nfon CK, Makepeace BL, Njongmeta LM, Hastings IM, Pfarr KM, Renz A, Tanya VN, Trees AJ. Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). J Infect Dis 2005; 192:483–1493.
  • 13. Wildenburg G, Korten S, Mainuka P, Büttner DW.Ivermectin influence on the mast cell activity in nodules of onchocerciasis patients. Trop Med Int Health 1998; 3: 918–925.
  • 14. Pejler G, Ronnberg E, Waern I, Wernersson S. Mast cell proteases: multifaceted regulators of inflammatory disease. Blood 2010; 115: 4981–4990.
  • 15. Bell WJ, Schulz M, Wefelmeyer U.Mast cell granule composition and tissue location- a close correlation. Histol Histopathol2000; 15: 937–946.
  • 16. Kuther K, Audige L, Kube P.Bovine mast cells: distribution, density, heterogeneity, and influence of fixation techniques. Cell Tissue Res1998;293: 111–119.
  • 17. Trivedi NN, Caughey GH. Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol2010; 42: 257–267.
  • 18. Welle M. Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukoc Biol1997; 61:233–245.
  • 19. Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Forster I, Kirschning CJ, Martin C et al. CCL17 controls mast cells for the defense against filarial larval entry.J Immunol2011; 186: 4845–4852.
  • 20. Cooper PJ, Schwartz LB, Irani AM, Awadzi K, Gudarian RH, Nutman TB.Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin. J Infect Dis2001; 186: 1307–1313.
  • 21.Leder LD. The chloroacetate esterase reaction. Am J Dermatopathol 1979; 1: 39–42.
  • 22. Pfarr K, Hoerauf A.The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine. PLoS Med2005; 2: 289–292.
  • 23. Yamada R, Floate KD, Riegler M, O’Neill SL.Male development time ınfluences the strength of Wolbachia-induced cytoplasmic ıncompatibility expression in Drosophila melanogaster. Genetics 2007; 177: 801–808.
  • 24. Taylor MJ, Hoerauf A. Wolbachia bacteria of filarial nematodes. Parasitol Today 1999; 15: 437–442.
  • 25. Henkle-Duhrsen K, Eckelt VH, Wildenburg G, Blaxter M, Walter RD. Gene structure, activity and localization of a catalase from intracellular bacteria in O. volvulus. Mol Biochem Parasitol 1998; 96: 69–81.
  • 26. Taylor MJ. Wolbachia endosymbiotic bacteria of filarial nematodes. A new insight into disease pathogenesis and control. Arch Med Res 2002; 33: 422–424.
  • 27.Bot I, Shi GP, Kovanen PT. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol 2015;35: 265–271.
  • 28. Leskinen M, Wang Y, Leszczynski D, Lindstedt KA, Kovanen P T.Mast cell chymase induces apoptosis of vascular smooth muscle cells. Arteroscler Thromb Vasc Biol 2001; 21: 516–522.
  • 29. Wildenburg G, Plenge-Bönig A, Renz A, Fischer P, Büttner DW. Distribution of mast cells and their correlation with inflammatory cells around O. gutturosa, O. tarsicola, O. ochengiand O. flexuosa. Parasitol Res 1997; 83: 109–120.
  • 30. Taylor MJ.Wolbachia bacteria of filarial nematodes in the pathogenesis of disease and as a target for control. T Roy Soc Trop Med H 2000; 94: 596–598.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Effect of different extenders on motility and some sperm kinematics parameters in Norduz goat semen

Koray TEKİN, Ali DAŞKIN

Effects of acetic acid supplementation in broiler chickens orallychallenged with Salmonella Pullorum

Gulbeena SALEEM, Rukhshanda RAMZAAN, Farina KHATTAK, Raheela AKHTAR

Influence of dietary vitamin D3 supplementation on the sarcomere length,Warner Bratzler shear force, shortening of ageing time, and sensory acceptanceof culinary beef muscles

Urszula Karolina RAFALSKA

Research of the effects of autologous cancellous bone graft and hyaluronic acidon the healing of bone defects experimentally induced in rabbits

Mehmet Cengiz HAN, Enis KARABULUT, Aydın SAĞLIYAN, Mustafa ÖZKARACA

Mast cell typing in aortic onchocerciasis and the immunohistochemicaldemonstration of Wo l b a c h i a bacteria

Melek KOÇAK, Zafer ÖZYILDIZ, İsmail Şah HAREM, Rahşan YILMAZ

Effects of full-fat soybean diet on performance, carcass characteristics,and fatty acid composition of Hanwoo steers

Sungil KIM, Jihong LEE, Sungkwon PARK

Diagnostic and therapeutic approach to cardiac myxosarcoma in a dog

Meriç KOCATÜRK, Murat BİÇER, Ahmet AKKOÇ, Hakan SALCI, Zeki YILMAZ, Saim SAĞ

Age-related changes in the growth performance, meat quality, and oxidativeprocesses in breast muscles of three chicken genotypes

Agata MARZEC, Zaneta ZDANOWSKA SASIADEK, Dariusz GOZDOWSKI, Nina STRZALKOWSKA, Monika MICHALCZUK, Krzysztof DAMAZIAK, Artur JOZWIK

Comparison of PCR tests for the detection of Mycoplasmaagalactiae in sheep and goats

Mihriban ÜLGEN, Hüban GÖÇMEN, Ruben Sebastian ROSALES, Roger David AYLING

Comparative evaluation of sequence analysis of 16S rRNA and rpoB genes for identification of aquatic mycobacteria

Fazel POURAHMAD, H. Randolph RICHARDS