Fevziye Burcu ŞİRİN, Duygu Kumbul DOĞUÇ, Hüseyin VURAL, İbrahim EREN, İkbal İNANLI, Recep SÜTCÜ, Namik DELİBAŞ
Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease
Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2α levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found. Conclusion: Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.
Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease
Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2α levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found. Conclusion: Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.
Keywords:
Alzheimer disease, minimal cognitive impairment, oxidative stress, isoprostane, melatonin,
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| Bibtex | @ { tbtkmedical149046, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1073 - 1077}, doi = {}, title = {Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease}, key = {cite}, author = {Şirin, Fevziye Burcu and Doğuç, Duygu Kumbul and Vural, Hüseyin and Eren, İbrahim and İnanlı, İkbal and Sütcü, Recep and Delibaş, Namik} } |
| APA | Şirin, F , Doğuç, D , Vural, H , Eren, İ , İnanlı, İ , Sütcü, R , Delibaş, N . (2015). Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease . Turkish Journal of Medical Sciences , 45 (5) , 1073-1077 . |
| MLA | Şirin, F , Doğuç, D , Vural, H , Eren, İ , İnanlı, İ , Sütcü, R , Delibaş, N . "Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease" . Turkish Journal of Medical Sciences 45 (2015 ): 1073-1077 < |
| Chicago | Şirin, F , Doğuç, D , Vural, H , Eren, İ , İnanlı, İ , Sütcü, R , Delibaş, N . "Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease". Turkish Journal of Medical Sciences 45 (2015 ): 1073-1077 |
| RIS | TY - JOUR T1 - Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease AU - Fevziye Burcu Şirin , Duygu Kumbul Doğuç , Hüseyin Vural , İbrahim Eren , İkbal İnanlı , Recep Sütcü , Namik Delibaş Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1073 EP - 1077 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER - |
| EndNote | %0 Turkish Journal of Medical Sciences Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease %A Fevziye Burcu Şirin , Duygu Kumbul Doğuç , Hüseyin Vural , İbrahim Eren , İkbal İnanlı , Recep Sütcü , Namik Delibaş %T Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U |
| ISNAD | Şirin, Fevziye Burcu , Doğuç, Duygu Kumbul , Vural, Hüseyin , Eren, İbrahim , İnanlı, İkbal , Sütcü, Recep , Delibaş, Namik . "Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1073-1077 . |
| AMA | Şirin F , Doğuç D , Vural H , Eren İ , İnanlı İ , Sütcü R , Delibaş N . Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1073-1077. |
| Vancouver | Şirin F , Doğuç D , Vural H , Eren İ , İnanlı İ , Sütcü R , Delibaş N . Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1073-1077. |
| IEEE | F. Şirin , D. Doğuç , H. Vural , İ. Eren , İ. İnanlı , R. Sütcü ve N. Delibaş , "Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1073-1077, Ara. 2015 |
- ISSN: 1300-0144
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
52.9b40.5b
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