A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease

Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic acid levels were measured using Roche E170 and Beckman Coulter DXI 800 immunoassays (chemiluminescence) according to the manufacturers' guideline in all centers. Results: We evaluated the results of folic acid and vitamin B12 in Alzheimer disease, other dementias and geriatric patients. No significant difference between the groups regarding the routine control of biochemical parameters was observed. Conclusion: Currently, serum folic and vitamin B12 levels are not diagnostically reliable tests for screening presymptomatic Alzheimer disease. However, the results may statistically be significant if we increase the sample size.

A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease

Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic acid levels were measured using Roche E170 and Beckman Coulter DXI 800 immunoassays (chemiluminescence) according to the manufacturers' guideline in all centers. Results: We evaluated the results of folic acid and vitamin B12 in Alzheimer disease, other dementias and geriatric patients. No significant difference between the groups regarding the routine control of biochemical parameters was observed. Conclusion: Currently, serum folic and vitamin B12 levels are not diagnostically reliable tests for screening presymptomatic Alzheimer disease. However, the results may statistically be significant if we increase the sample size.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical149059, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1159 - 1166}, doi = {}, title = {A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease}, key = {cite}, author = {Ulusu, Nuriye Nuray and Yılmaz, Gökhan and Erbayraktar, Zübeyde and Evlice, Ahmet Turan and Aras, Sevgi and Yener, Görsev and Avcı, Aslihan} }
APA Ulusu, N , Yılmaz, G , Erbayraktar, Z , Evlice, A , Aras, S , Yener, G , Avcı, A . (2015). A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease . Turkish Journal of Medical Sciences , 45 (5) , 1159-1166 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149059
MLA Ulusu, N , Yılmaz, G , Erbayraktar, Z , Evlice, A , Aras, S , Yener, G , Avcı, A . "A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease" . Turkish Journal of Medical Sciences 45 (2015 ): 1159-1166 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149059>
Chicago Ulusu, N , Yılmaz, G , Erbayraktar, Z , Evlice, A , Aras, S , Yener, G , Avcı, A . "A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease". Turkish Journal of Medical Sciences 45 (2015 ): 1159-1166
RIS TY - JOUR T1 - A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease AU - Nuriye Nuray Ulusu , Gökhan Yılmaz , Zübeyde Erbayraktar , Ahmet Turan Evlice , Sevgi Aras , Görsev Yener , Aslihan Avcı Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1159 EP - 1166 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease %A Nuriye Nuray Ulusu , Gökhan Yılmaz , Zübeyde Erbayraktar , Ahmet Turan Evlice , Sevgi Aras , Görsev Yener , Aslihan Avcı %T A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Ulusu, Nuriye Nuray , Yılmaz, Gökhan , Erbayraktar, Zübeyde , Evlice, Ahmet Turan , Aras, Sevgi , Yener, Görsev , Avcı, Aslihan . "A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1159-1166 .
AMA Ulusu N , Yılmaz G , Erbayraktar Z , Evlice A , Aras S , Yener G , Avcı A . A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1159-1166.
Vancouver Ulusu N , Yılmaz G , Erbayraktar Z , Evlice A , Aras S , Yener G , Avcı A . A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1159-1166.
IEEE N. Ulusu , G. Yılmaz , Z. Erbayraktar , A. Evlice , S. Aras , G. Yener ve A. Avcı , "A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1159-1166, Ara. 2015

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