Is Alzheimer disease related to age-related macular degeneration?

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD was higher in patients with AMD (40.7% in AMD and 20.4% in control group, P = 0.03), and particularly higher in late dry (nonvascular) AMD (d-AMD) patients (71.4% in d-AMD and 31.1% in late wet (vascular) AMD, P = 0.007). d-AMD patients performed worse than controls on all tests. There was also an association between age, sex, and low education and neuropsychiatric tests scores (P < 0.01). However, there was no association between visual acuity and neuropsychiatric tests scores. Conclusion: The increased frequency of AD in patients with AMD is significant. This study demonstrated the importance of cognitive assessment in patients with AMD, particularly in the d-AMD type.

Is Alzheimer disease related to age-related macular degeneration?

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD was higher in patients with AMD (40.7% in AMD and 20.4% in control group, P = 0.03), and particularly higher in late dry (nonvascular) AMD (d-AMD) patients (71.4% in d-AMD and 31.1% in late wet (vascular) AMD, P = 0.007). d-AMD patients performed worse than controls on all tests. There was also an association between age, sex, and low education and neuropsychiatric tests scores (P < 0.01). However, there was no association between visual acuity and neuropsychiatric tests scores. Conclusion: The increased frequency of AD in patients with AMD is significant. This study demonstrated the importance of cognitive assessment in patients with AMD, particularly in the d-AMD type.

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Potential genetic biomarkers in the early diagnosisof Alzheimer disease: APOE and BIN1

GÜLHAN KAYA, ESRA GÜNDÜZ, MURADİYE ACAR, Ömer Faruk HATİPOĞLU, BURCU ACAR, ATİLLA İLHAN, MEHMET GÜNDÜZ

Forensic medicine evaluation of Alzheimer patients: a series from Ankara, Turkey

MEHMET CAVLAK, RAMAZAN AKÇAN, ALİ RIZA TÜMER, AYSUN BALSEVEN ODABAŞI, AYKUT LALE, MAHMUT ŞERİF YILDIRIM, EYUP RUŞEN HEYBET

Alzheimer disease and anesthesia

GÖZDE İNAN, ZERRİN ÖZKÖSE ŞATIRLAR

Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*

Muhsin ERASLAN, Eren ÇERMAN, Osman ÇEKİÇ, Sevcan BALCI, Volkan DERİCİOĞLU, Özlem ŞAHİN, Devran SÜER, Biman CHABOU, Emine Neşe Tuncer ELMACI

A comparison of hair and serum trace elements in patients with Alzheimer disease and healthy participants

EMİNE RABİA KOÇ, ATİLLA İLHAN, ZÜBEYDE AYTÜRK, BURCU ACAR, MUKADDES GÜRLER, AYNUR ALTUNTAŞ, MUSTAFA KARAPİRLİ, ABDURRAHMAN SAİD BODUR

Impaired cognitive performance and hippocampal atrophy in Parkinson disease

DEMET YILDIZ, SEVDA ERER, MEHMET ZARİFOĞLU, BAHATTİN HAKYEMEZ, MUSTAFA BAKAR, NECDET KARLI, ZEYNEP NİGAR VARLIBAŞ, FATİH TUFAN

Malnutrition is associated with dementia severity and geriatricsyndromes in patients with Alzheimer disease

Demet YILDIZ, Nilüfer Büyükkoyuncu PEKEL, Ahmet Kasim KILIÇ, Elif Nalan TOLGAY, Fatih TUFAN

Cognitive problems related to vertebrobasilar circulation

Abdulkadir KOÇER

Association of CLU and TLR2 gene polymorphisms with late-onsetAlzheimer disease in a northwestern Iranian population

Nasim SOHRABIFAR, Jalal GHARESOURAN, Mahnaz TALEBI, Morteza GHOJAZADEH, Seiied Mojtaba Mohaddes ARDEBILI

A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease

Nuriye Nuray ULUSU, Gökhan YILMAZ, Zübeyde ERBAYRAKTAR, Ahmet Turan EVLİCE, Sevgi ARAS, Görsev YENER, Aslihan AVCI