Is Alzheimer disease related to age-related macular degeneration?

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD was higher in patients with AMD (40.7% in AMD and 20.4% in control group, P = 0.03), and particularly higher in late dry (nonvascular) AMD (d-AMD) patients (71.4% in d-AMD and 31.1% in late wet (vascular) AMD, P = 0.007). d-AMD patients performed worse than controls on all tests. There was also an association between age, sex, and low education and neuropsychiatric tests scores (P < 0.01). However, there was no association between visual acuity and neuropsychiatric tests scores. Conclusion: The increased frequency of AD in patients with AMD is significant. This study demonstrated the importance of cognitive assessment in patients with AMD, particularly in the d-AMD type.

Is Alzheimer disease related to age-related macular degeneration?

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD was higher in patients with AMD (40.7% in AMD and 20.4% in control group, P = 0.03), and particularly higher in late dry (nonvascular) AMD (d-AMD) patients (71.4% in d-AMD and 31.1% in late wet (vascular) AMD, P = 0.007). d-AMD patients performed worse than controls on all tests. There was also an association between age, sex, and low education and neuropsychiatric tests scores (P < 0.01). However, there was no association between visual acuity and neuropsychiatric tests scores. Conclusion: The increased frequency of AD in patients with AMD is significant. This study demonstrated the importance of cognitive assessment in patients with AMD, particularly in the d-AMD type.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical149053, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1115 - 1121}, doi = {}, title = {Is Alzheimer disease related to age-related macular degeneration?}, key = {cite}, author = {Demirci, Seden and Güneş, Alime and Demirci, Kadir and Demirci, Serpil and Tök, Levent and Tök, Özlem} }
APA Demirci, S , Güneş, A , Demirci, K , Demirci, S , Tök, L , Tök, Ö . (2015). Is Alzheimer disease related to age-related macular degeneration? . Turkish Journal of Medical Sciences , 45 (5) , 1115-1121 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149053
MLA Demirci, S , Güneş, A , Demirci, K , Demirci, S , Tök, L , Tök, Ö . "Is Alzheimer disease related to age-related macular degeneration?" . Turkish Journal of Medical Sciences 45 (2015 ): 1115-1121 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149053>
Chicago Demirci, S , Güneş, A , Demirci, K , Demirci, S , Tök, L , Tök, Ö . "Is Alzheimer disease related to age-related macular degeneration?". Turkish Journal of Medical Sciences 45 (2015 ): 1115-1121
RIS TY - JOUR T1 - Is Alzheimer disease related to age-related macular degeneration? AU - Seden Demirci , Alime Güneş , Kadir Demirci , Serpil Demirci , Levent Tök , Özlem Tök Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1115 EP - 1121 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Is Alzheimer disease related to age-related macular degeneration? %A Seden Demirci , Alime Güneş , Kadir Demirci , Serpil Demirci , Levent Tök , Özlem Tök %T Is Alzheimer disease related to age-related macular degeneration? %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Demirci, Seden , Güneş, Alime , Demirci, Kadir , Demirci, Serpil , Tök, Levent , Tök, Özlem . "Is Alzheimer disease related to age-related macular degeneration?". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1115-1121 .
AMA Demirci S , Güneş A , Demirci K , Demirci S , Tök L , Tök Ö . Is Alzheimer disease related to age-related macular degeneration?. Turkish Journal of Medical Sciences. 2015; 45(5): 1115-1121.
Vancouver Demirci S , Güneş A , Demirci K , Demirci S , Tök L , Tök Ö . Is Alzheimer disease related to age-related macular degeneration?. Turkish Journal of Medical Sciences. 2015; 45(5): 1115-1121.
IEEE S. Demirci , A. Güneş , K. Demirci , S. Demirci , L. Tök ve Ö. Tök , "Is Alzheimer disease related to age-related macular degeneration?", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1115-1121, Ara. 2015

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