Impaired cognitive performance and hippocampal atrophy in Parkinson disease

Background/aim: Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients. Materials and methods: Thirty-three patients with diagnosis of idiopathic PD and 16 healthy subjects were included in this study. PD patients were divided into two groups as normal cognitive function and mild cognitive impairment (MCI). The Mini-Mental State Examination and detailed cognitive assessment tests were performed for all patients for cognitive analyses. Depression was excluded by the Geriatric Depression Scale. Results: The mean onset age of disease was 55 years for PD patients without dementia and 59 for PD patients with MCI. According to the Hoehn-Yahr scales, 24% of patients had grade 1, 58% had grade 2, and 18% had grade 3 disease. Right and left hippocampal volumes decreased along with cognitive test scores in PD patients. Increased right hippocampal volume was correlated with forward number test in the MCI-PD group. Conclusion: These findings suggest that memory deficit is associated with hippocampal atrophy in PD patients.

Impaired cognitive performance and hippocampal atrophy in Parkinson disease

Background/aim: Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients. Materials and methods: Thirty-three patients with diagnosis of idiopathic PD and 16 healthy subjects were included in this study. PD patients were divided into two groups as normal cognitive function and mild cognitive impairment (MCI). The Mini-Mental State Examination and detailed cognitive assessment tests were performed for all patients for cognitive analyses. Depression was excluded by the Geriatric Depression Scale. Results: The mean onset age of disease was 55 years for PD patients without dementia and 59 for PD patients with MCI. According to the Hoehn-Yahr scales, 24% of patients had grade 1, 58% had grade 2, and 18% had grade 3 disease. Right and left hippocampal volumes decreased along with cognitive test scores in PD patients. Increased right hippocampal volume was correlated with forward number test in the MCI-PD group. Conclusion: These findings suggest that memory deficit is associated with hippocampal atrophy in PD patients.

Kaynakça

Mayeux R, Denaro J, Hemenegildo N, Marder K, Tang MX, Cote LJ, Stern Y. A population-based investigation of Parkinson’s disease with and without dementia. Relationship to age and gender. Arch Neurol 1992; 49: 492–497.

Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sİrensen P. Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology 2001; 56: 730–736.

Burn DJ, Rowan EN, Allan LM, Molloy S, O’Brien JT, McKeith IG. Motor subtype and cognitive decline in Parkinson’s disease, Parkinson’s disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 2006; 77: 585–589.

Burn DJ, Rowan EN, Minett T, Sanders J, Myint P, Richardson J, Thomas A, Newby J, Reid J, O’Brien JT et al. Extrapyramidal features in Parkinson’s disease with and without dementia and dementia with Lewy bodies: a cross-sectional comparative study. Mov Disord 2003; 18: 884–889.

Stern Y, Richards M, Sano M, Mayeux R. Comparison of cognitive changes in patients with Alzheimer’s and Parkinson’s disease. Arch Neurol 1993; 50: 1040–1045. 6.

Huber SJ, Shuttleworth EC, Freidenberg DL.

Neuropsychological differences between the dementias of

Alzheimer’s and Parkinson’s diseases. Arch Neurol 1989; 46: 1287–1291.

Ballard CG, Aarsland D, McKeith I, O’Brien J, Gray A, Cormack F, Burn D, Cassidy T, Starfeldt R, Larsen JP et al. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 2002; 59: 1714–1720.

Bak TH, Crawford LM, Hearn VC, Mathuranath PS, Hodges JR. Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). Neurocase 2005; 11: 268–273.

De Wells SE, Hedley-Whyte T, Growdon JH. Neuropathological distinction between Parkinson’s dementia and Parkinson’s plus Alzheimer’s disease. Ann Neurol 1989; 26: 309–320.

Cordato NJ, Halliday GM, Harding AJ, Hely MA, Morris JG. Regional brain atrophy in progressive supranuclear palsy and Lewy body disease. Ann Neurol 2000; 47: 718–728.

Laakso MP, Partanen K, Riekkinen P, Lehtovirta M, Helkala EL, Hallikainen M, Hanninen T, Vainio P, Soininen H. Hippocampal volumes in Alzheimer’s disease, Parkinson’s disease with and without dementia, and in vascular dementia: an MRI study. Neurology 1996; 46: 678–681.

Camicioli R, Moore MM, Kinney A, Corbridge E, Glassberg K, Kaye JA. Parkinson’s disease is associated with hippocampal atrophy. Mov Disord 2003; 18: 784–790.

Korf ES, Wahlund LO, Visser PJ, Scheltens P. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology 2004; 63: 94–100.

Burton EJ, McKeith IG, Burn DJ, Williams ED, O’Brien JT. Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls. Brain 2004; 127: 791–800.

Burton EJ, McKeith IG, Burn DJ, O’Brien JT. Brain atrophy rates in Parkinson’s disease with and without dementia using serial magnetic resonance imaging. Mov Disord 2005; 20: 1571–1576.

Hu MT, White SJ, Chaudhuri KR, Morris RG, Bydder GM, Brooks DJ. Correlating rates of cerebral atrophy in Parkinson’s disease with measures of cognitive decline. J Neural Transm 2001; 108: 571–580.

Jacobs DM, Marder K, Côté LJ, Sano M, Stern Y, Mayeux R. Neuropsychological characteristics of preclinical dementia in Parkinson’s disease. Neurology 1995; 45: 1691–1696.

van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. Hippocampal atrophy in Alzheimer disease: age matters. Neurology 2006; 66: 236–819.

Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann Neurol 2000; 47: 430–920.

Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Mack WJ, Kramer JH, Weiner MW, Schuff N et al. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology 2005; 65: 565–571.

Jack CR Jr, Shiung MM, Weigand SD, O’Brien PC, Gunter JL, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Tangalos EG et al. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology 2005; 65: 1227– 1231.

Geroldi C, Rossi R, Calvagna C, Testa C, Bresciani L, Binetti G, Zanetti O, Frisoni GB. Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment. J Neurol Neurosurg Psychiatry 2006; 77: 1219–1222.

Bell-McGinty S, Lopez OL, Meltzer CC, Scanlon JM, Whyte EM, Dekosky ST, Becker JT. Differential cortical atrophy in subgroups of mild cognitive impairment. Arch Neurol 2005; 62: 1393–1407.

Apostolova LG, Dutton RA, Dinov ID, Hayashi KM, Toga AW, Cummings JL, Thompson PM. Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps. Arch Neurol 2006; 63: 693–709.

Becker JT, Davis SW, Hayashi KM, Meltzer CC, Toga AW, Lopez OL, Thompson PM. Imaging Methods and Analysis in Geriatrics Research Group. Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment. Arch Neurol 2006; 63: 97–101.

Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, O’Brien JT. MRI study of caudate nucleus volume in Parkinson’s disease with and without dementia with Lewy bodies and Alzheimer’s disease. Dement Geriatr Cogn Disord 2003; 16: 57–63.

Messina D, Cerasa A, Condino F, Arabia G, Novellino F, Nicoletti G, Salsone M, Morelli M, Lanza PL, Quattrone A. Patterns of brain atrophy in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy. Parkinsonism Relat Disord 2011; 17: 172–176.

Jokinen P, Brück A, Aalto S, Forsback S, Parkkola R, Rinne JO. Impaired cognitive performance in Parkinson’s disease is related to caudate dopaminergic hypofunction and hippocampal atrophy. Parkinsonism Relat Disord 2009; 15: 88–93.

Kaynak Göster

Bibtex @ { tbtkmedical149061, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1173 - 1177}, doi = {}, title = {Impaired cognitive performance and hippocampal atrophy in Parkinson disease}, key = {cite}, author = {Yıldız, DEMET and Erer, SEVDA and Zarifoğlu, MEHMET and Hakyemez, BAHATTİN and Bakar, MUSTAFA and Karlı, NECDET and Varlıbaş, ZEYNEP NİGAR and Tufan, FATİH} }
APA Yıldız, D , Erer, S , Zarifoğlu, M , Hakyemez, B , Bakar, M , Karlı, N , Varlıbaş, Z , Tufan, F . (2015). Impaired cognitive performance and hippocampal atrophy in Parkinson disease . Turkish Journal of Medical Sciences , 45 (5) , 1173-1177 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149061
MLA Yıldız, D , Erer, S , Zarifoğlu, M , Hakyemez, B , Bakar, M , Karlı, N , Varlıbaş, Z , Tufan, F . "Impaired cognitive performance and hippocampal atrophy in Parkinson disease" . Turkish Journal of Medical Sciences 45 (2015 ): 1173-1177 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149061>
Chicago Yıldız, D , Erer, S , Zarifoğlu, M , Hakyemez, B , Bakar, M , Karlı, N , Varlıbaş, Z , Tufan, F . "Impaired cognitive performance and hippocampal atrophy in Parkinson disease". Turkish Journal of Medical Sciences 45 (2015 ): 1173-1177
RIS TY - JOUR T1 - Impaired cognitive performance and hippocampal atrophy in Parkinson disease AU - DEMET Yıldız , SEVDA Erer , MEHMET Zarifoğlu , BAHATTİN Hakyemez , MUSTAFA Bakar , NECDET Karlı , ZEYNEP NİGAR Varlıbaş , FATİH Tufan Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1173 EP - 1177 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Impaired cognitive performance and hippocampal atrophy in Parkinson disease %A DEMET Yıldız , SEVDA Erer , MEHMET Zarifoğlu , BAHATTİN Hakyemez , MUSTAFA Bakar , NECDET Karlı , ZEYNEP NİGAR Varlıbaş , FATİH Tufan %T Impaired cognitive performance and hippocampal atrophy in Parkinson disease %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Yıldız, DEMET , Erer, SEVDA , Zarifoğlu, MEHMET , Hakyemez, BAHATTİN , Bakar, MUSTAFA , Karlı, NECDET , Varlıbaş, ZEYNEP NİGAR , Tufan, FATİH . "Impaired cognitive performance and hippocampal atrophy in Parkinson disease". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1173-1177 .
AMA Yıldız D , Erer S , Zarifoğlu M , Hakyemez B , Bakar M , Karlı N , Varlıbaş Z , Tufan F . Impaired cognitive performance and hippocampal atrophy in Parkinson disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1173-1177.
Vancouver Yıldız D , Erer S , Zarifoğlu M , Hakyemez B , Bakar M , Karlı N , Varlıbaş Z , Tufan F . Impaired cognitive performance and hippocampal atrophy in Parkinson disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1173-1177.
IEEE D. Yıldız , S. Erer , M. Zarifoğlu , B. Hakyemez , M. Bakar , N. Karlı , Z. Varlıbaş ve F. Tufan , "Impaired cognitive performance and hippocampal atrophy in Parkinson disease", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1173-1177, Ara. 2015

18427 16497

Arşiv
Sayıdaki Diğer Makaleler

Potential genetic biomarkers in the early diagnosisof Alzheimer disease: APOE and BIN1

GÜLHAN KAYA, ESRA GÜNDÜZ, MURADİYE ACAR, Ömer Faruk HATİPOĞLU, BURCU ACAR, ATİLLA İLHAN, MEHMET GÜNDÜZ

Prevalence of cognitive impairment and related risk factors incommunity-dwelling elderly in Kayseri, Turkey

Sibel ARGUVANLI, Sibel AKIN, Elif Deniz ŞAFAK, Salime MUCUK, Ahmet ÖZTÜRK, Mustafa Mümtaz MAZICIOĞLU, Hatice Duygu KIZILÇAY, Şemsinnur GÖÇER

Plasma 8-isoPGF2? and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease

Fevziye Burcu ŞİRİN, Duygu Kumbul DOĞUÇ, Hüseyin VURAL, İbrahim EREN, İkbal İNANLI, Recep SÜTCÜ, Namik DELİBAŞ

COGNITIVE PROBLEMS RELATED TO VERTEBRO-BASILAR CIRCULATION

ABDULKADİR KOÇER

The value of FDG-PET/CT by using 3-dimensional stereotactic surface projection software analysis in the differential diagnosis of dementia

Esra ARSLAN, Özgül EKMEKÇİOĞLU, Fatma Arzu GÖRTAN, Zeynep Funda Engin AKCAN, Melih Engin ERKAN, Haci Murat EMÜL, Metin HALAÇ, Tevfik Fikret ÇERMİK, Kerim SÖNMEZOĞLU

Is Alzheimer disease related to age-related macular degeneration?

Seden DEMİRCİ, Alime GÜNEŞ, Kadir DEMİRCİ, Serpil DEMİRCİ, Levent TÖK, Özlem TÖK

Age-related macular degeneration and Alzheimer disease

EREN ÇERMAN, MUHSİN ERASLAN, OSMAN ÇEKİÇ

Why is Alzheimer's disease confused with other dementias?

DURSUN AYGÜN, İBRAHİM LEVENT GÜNGÖR

Alzheimer disease and anesthesia

GÖZDE İNAN, ZERRİN ÖZKÖSE ŞATIRLAR

Preface - Special Issue on: Alzheimer Disease: From Bench to Bedside'

MARK S KINDY, ÖMER AKYOL, KUMAR SAMBAMURTI