Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*

Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG and AD patients when compared to the control subjects (P = 0.004, P = 0.006, P < 0.001, respectively). The statistical evaluation showed no difference in any RNFL or GCC parameters between the AD and NTG groups (P > 0.05). There was a negative correlation between disease duration and average RNFL and GCC thicknesses (r = ?0.350, P = 0.027 and r = ?0.471, P = 0.002, respectively) and a positive correlation between duration and GLV (r = 0.427, P = 0.006) in the AD group. Conclusion: The average RNFL thickness, GCC thickness, and GLV rates may help in the diagnosis of AD as an additional examination and may provide some important clues about the duration of the disease.

Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*

Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG and AD patients when compared to the control subjects (P = 0.004, P = 0.006, P < 0.001, respectively). The statistical evaluation showed no difference in any RNFL or GCC parameters between the AD and NTG groups (P > 0.05). There was a negative correlation between disease duration and average RNFL and GCC thicknesses (r = ?0.350, P = 0.027 and r = ?0.471, P = 0.002, respectively) and a positive correlation between duration and GLV (r = 0.427, P = 0.006) in the AD group. Conclusion: The average RNFL thickness, GCC thickness, and GLV rates may help in the diagnosis of AD as an additional examination and may provide some important clues about the duration of the disease.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical149052, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1106 - 1114}, doi = {}, title = {Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*}, key = {cite}, author = {Eraslan, Muhsin and Çerman, Eren and Çekiç, Osman and Balcı, Sevcan and Dericioğlu, Volkan and Şahin, Özlem and Süer, Devran and Chabou, Biman and Elmacı, Emine Neşe Tuncer} }
APA Eraslan, M , Çerman, E , Çekiç, O , Balcı, S , Dericioğlu, V , Şahin, Ö , Süer, D , Chabou, B , Elmacı, E . (2015). Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease* . Turkish Journal of Medical Sciences , 45 (5) , 1106-1114 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149052
MLA Eraslan, M , Çerman, E , Çekiç, O , Balcı, S , Dericioğlu, V , Şahin, Ö , Süer, D , Chabou, B , Elmacı, E . "Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*" . Turkish Journal of Medical Sciences 45 (2015 ): 1106-1114 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149052>
Chicago Eraslan, M , Çerman, E , Çekiç, O , Balcı, S , Dericioğlu, V , Şahin, Ö , Süer, D , Chabou, B , Elmacı, E . "Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*". Turkish Journal of Medical Sciences 45 (2015 ): 1106-1114
RIS TY - JOUR T1 - Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease* AU - Muhsin Eraslan , Eren Çerman , Osman Çekiç , Sevcan Balcı , Volkan Dericioğlu , Özlem Şahin , Devran Süer , Biman Chabou , Emine Neşe Tuncer Elmacı Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1106 EP - 1114 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease* %A Muhsin Eraslan , Eren Çerman , Osman Çekiç , Sevcan Balcı , Volkan Dericioğlu , Özlem Şahin , Devran Süer , Biman Chabou , Emine Neşe Tuncer Elmacı %T Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease* %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Eraslan, Muhsin , Çerman, Eren , Çekiç, Osman , Balcı, Sevcan , Dericioğlu, Volkan , Şahin, Özlem , Süer, Devran , Chabou, Biman , Elmacı, Emine Neşe Tuncer . "Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1106-1114 .
AMA Eraslan M , Çerman E , Çekiç O , Balcı S , Dericioğlu V , Şahin Ö , Süer D , Chabou B , Elmacı E . Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*. Turkish Journal of Medical Sciences. 2015; 45(5): 1106-1114.
Vancouver Eraslan M , Çerman E , Çekiç O , Balcı S , Dericioğlu V , Şahin Ö , Süer D , Chabou B , Elmacı E . Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*. Turkish Journal of Medical Sciences. 2015; 45(5): 1106-1114.
IEEE M. Eraslan , E. Çerman , O. Çekiç , S. Balcı , V. Dericioğlu , Ö. Şahin , D. Süer , B. Chabou ve E. Elmacı , "Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease*", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1106-1114, Ara. 2015

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