Bone mineral density and vitamin D status in children and adolescents with congenital adrenal hyperplasia

To determine the prevalence of and risk factors for decreased bone mineral density (BMD) and vitamin D deficiency in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: This study was conducted on 30 girls and 22 boys with CAH (age range = 5-20 years) with median age of 12.0 years. BMD values of lumbar vertebras (L1-L4), which were determined by dual-energy X-ray absorptiometry, were used to calculate z-scores according to chronological age. A serum 25-hydroxyvitamin D level of

Bone mineral density and vitamin D status in children and adolescents with congenital adrenal hyperplasia

To determine the prevalence of and risk factors for decreased bone mineral density (BMD) and vitamin D deficiency in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: This study was conducted on 30 girls and 22 boys with CAH (age range = 5-20 years) with median age of 12.0 years. BMD values of lumbar vertebras (L1-L4), which were determined by dual-energy X-ray absorptiometry, were used to calculate z-scores according to chronological age. A serum 25-hydroxyvitamin D level of

___

  • Miller WL, Acherman JC, Flück CE. The adrenal cortex and its disorder. In: Sperling MA, editor. Pediatric Endocrinology. 3rd ed. Philadelphia, PA, USA: Saunders Elsevier; 2008. pp. 444–511.
  • Nimkarn S, Lin-Su K, New MI. Steroid 21 hydroxylase deficiency congenital adrenal hyperplasia. Pediatr Clin North Am 2011; 58: 1281–1300.
  • Reisch N, Arlt W, Krone N. Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Res Paediatr 2011; 76: 73–85.
  • Leonard MB. Glucocorticoid-induced osteoporosis in children: impact of the underlying disease. Pediatr 2007; 119: 166–174.
  • Kim HJ. New understanding of glucocorticoid action in bone cells. BMB Rep 2010; 43: 524–529.
  • Falhammar H, Filipsson H, Holmdahl G, Janson PO, Nordenskjöld A, Hagenfeldt K, Thorén M. Fractures and bone mineral density in adult women with 21-hydroxylase deficiency. J Clin Endocrinol Metab 2007; 92: 4643–4649.
  • Sciannamblo M, Russo G, Cuccato D, Chiumello G, Mora S. Reduced bone mineral density and increased bone metabolism rate in young adult patients with 21-hydroxylase deficiency. J Clin Endocrinol Metab 2006; 91: 4453–4458.
  • King JA, Wisniewski AB, Bankowski BJ, Carson KA, Zacur HA, Migeon CJ. Long-term corticosteroid replacement and bone mineral density in adult women with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab 2006; 91: 865– 8
  • Bachelot A, Plu-Bureau G, Thibaud E, Laborde K, Pinto G, Samara D, Nihoul-Fékété C, Kuttenn F, Polak M, Touraine P. Long-term outcome of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Res 2007; 67: 268–276.
  • Cetinkaya S, Kara C. The effect of glucocorticoid replacement therapy on bone mineral density in children with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab 2011; 24: 265–269.
  • Abd El Dayem SM, Anwar GM, Salama H, Kamel AF, Emara N. Bone mineral density, bone turnover markers, lean mass, and fat mass in Egyptian children with congenital adrenal hyperplasia. Arch Med Sci 2010; 6: 104–110.
  • Sahakitrungruang T, Wacharasindhu S, Supornsilchai V, Srivuthana S, Kingpetch K. Bone mineral density and body composition in prepubertal and adolescent patients with the classical form of 21-hydroxylase deficiency. J Med Assoc Thai 2008; 91: 705–710.
  • Fleischman A, Ringelheim J, Feldman HA, Gordon CM. Bone mineral status in children with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab 2007; 20: 227–235.
  • Girgis R, Winter JS. The effects of glucocorticoid replacement therapy on growth, bone mineral density, and bone turnover markers in children with congenital adrenal hyperplasia. J Clin Endocrinol Metab 1997; 82: 3926–3929.
  • Cameron FJ, Kaymakci B, Byrt EA, Ebeling PR, Warne GL, Wark JD. Bone mineral density and body composition in congenital adrenal hyperplasia. J Clin Endocrinol Metab 1995; 80: 2238–2243.
  • Elnecave RH, Kopacek C, Rigatto M, Keller Brenner J, Sisson de Castro JA. Bone mineral density in girls with classical congenital adrenal hyperplasia due to CYP21 deficiency. J Pediatr Endocrinol Metab 2008; 21: 1155–1162. de Almeida Freire PO, de Lemos-Marini SH, Maciel-Guerra AT, Morcillo AM, Matias Baptista MT, de Mello MP, Guerra G Jr. Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a cross-sectional study of factors involved in bone mineral density. J Bone Miner Metab 2003; 21: 396–401.
  • Paganini C, Radetti G, Livieri C, Braga V, Migliavacca D, Adami S. Height, bone mineral density and bone markers in congenital adrenal hyperplasia. Horm Res 2000; 54: 164–168.
  • Bachelot A, Chakhtoura Z, Samara-Boustani D, Dulon J, Touraine P, Polak M. Bone health should be an important concern in the care of patients affected by 21 hydroxylase deficiency. Int J Pediatr Endocrinol 2010; 2010: 326275.
  • Collins D, Jasani C, Fogelman I, Swaminathan R. Vitamin D and bone mineral density. Osteopor Int 1998; 8: 110–114.
  • Okten A, Cakir M, Makuloglu M. Bone mineral status, bone turnover markers and vitamin D status in children with congenital adrenal hyperplasia. Minerva Endocrinol 2012; 37: 275–281.
  • Gökçay, G, Furman, A, Neyzi, O. Updated growth curves for Turkish children aged 15 days to 60 months. Child Care Health Dev 2008; 34: 454–463.
  • Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006; 95: 1635–1641.
  • Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122: 398–417.
  • Goksen D, Darcan S, Coker M, Kose T. Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom 2006; 9: 84–90.
  • Gordon CM, Baim S, Bianchi ML, Bishop NJ, Hans DB, Kalkwarf H, Langman C, Leonard MB, Plotkin H, Rauch F et al. International Society for Clinical Densitometry. Special report on the 2007 Pediatric Position Development Conference of the International Society for Clinical Densitometry. South Med J 2008; 101: 740–743.
  • Schmidt S, Mellström D, Norjavaara E, Sundh SV, Saalman R. Low bone mineral density in children and adolescents with inflammatory bowel disease: a population-based study from Western Sweden. Inflamm Bowel Dis 2009; 15: 1844–1850.
  • Rauch F, Plotkin H, DiMeglio L, Engelbert RH, Henderson RC, Munns C, Wenkert D, Zeitler P. Fracture prediction and the definition of osteoporosis in children and adolescents: the ISCD 2007 Pediatric Official Positions. J Clin Densitom 2008; 11: 22–28.
  • Shakinba M, Samane T, Nafei Z. The optimal dose of vitamin D in growing girls during academic years: a randomized trial. Turk J Med Sci 2011; 41: 33–37.
  • Baroncelli GI, Bereket A, El Kholy M, Audì L, Cesur Y, Ozkan B, Rashad M, Fernández-Cancio M, Weisman Y, Saggese G et al. Rickets in the Middle East: role of environment and genetic predisposition. J Clin Endocrinol Metab 2008; 93: 1743–1750.
  • Akman AO, Tumer L, Hasanoglu A, Ilhan M, Caycı B. Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey. Pediatr Int 2011; 53: 968–973.
  • Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol 2012; 4: 25–29.
  • Hatun Ş, Ozkan B, Bereket A. Vitamin D deficiency and prevention: Turkish experience. Acta Paediatr 2011; 100: 1195–1199.
  • Hatun S, Bereket A, Ozkan B, Coskun T, Kose R, Calikoglu AS. Free vitamin D supplementation for every infant in Turkey. Arch Dis Child 2007; 92: 373–374.
  • Kurahashi I, Matsunuma A, Kawane T, Abe M, Horiuchi N. Dexamethasone enhances vitamin D-24-hydroxylase expression in osteoblastic (UMR-106) and renal (LLC-PK 1 ) cells treated with 1α,25-dihydroxyvitamin D 3 . Endocrine 2002; 17: 109–118.
  • Dhawan P, Christakos S. Novel regulation of 25-hydroxyvitamin D 3 24-hydroxylase (24(OH)ase) transcription by glucocorticoids: cooperative effects of the glucocorticoid receptor, C/EBPβ, and the vitamin D receptor in 24(OH)ase transcription. J Cell Biochem 2010; 110: 1314–1323.
  • Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ, Melamed ML. Association of glucocorticoid use and low 25-hydroxyvitamin D levels: results from the National Health and Nutrition Examination Survey (NHANES): 2001-2006. J Clin Endocrinol Metab 2011; 96: 3838–3845.
  • Sentongo TA, Semaeo EJ, Stettler N, Piccoli DA, Stallings VA, Zemel BS. Vitamin D status in children, adolescents, and young adults with Crohn disease. Am J Clin Nutr 2002; 76: 1077–1081.
  • Robinson AB, Thierry-Palmer M, Gibson KL, Rabinovich CE. Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis. J Pediatr 2012; 160: 297–302.
  • Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010; 125: 995–1000.
  • Akbıyık F, Tiryaki T, Şenel E, Mambet E, Livanelioğlu Z, Atayurt H. Feminizing genitoplasty: an evaluation of 41 patients in 8 years. Turk J Med Sci 2010; 40: 813–818.
  • Stikkelbroeck NM, Beerendonk C, Willemsen WN, SchreudersBais CA, Feitz WFJ, Rieu PN, Hermus AR, Otten BJ. The long term outcome of feminizing genital surgery for congenital adrenal hyperplasia: anatomical, functional and cosmetic outcomes, psychosexual development, and satisfaction in adult female patients. J Pediatr Adolesc Gynecol 2003; 16: 289–296.
  • Alizai NK, Thomas DF, Lilford RJ, Batchelor AG, Johnson N. Feminizing genitoplasty for congenital adrenal hyperplasia: what happens at puberty? J Urol 1999; 161: 1588–1591.
  • Oner O, Aycan Z, Tiryaki T, Soy D, Cetinkaya E, Kibar E. Variables related to behavioral and emotional problems and gender typed behaviors in female patients with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab 2009; 22: 143–151.
  • Sanches SA, Wiegers TA, Otten BJ, Claahsen-van der Grinten HL. Physical, social and societal functioning of children with congenital adrenal hyperplasia (CAH) and their parents, in a Dutch population. Int J Pediatr Endocrinol 2012; 2012: 2–8.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Epistaxis in geriatric patients

Alper YÜKSEL, Hanifi KURTARAN, Ekrem Said KANKILIÇ, Nebil ARK, Kadriye Şerife UĞUR, Mehmet GÜNDÜZ

Protective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in rats

Esin OĞUZHANOĞLU, Ahmet Cenk ANDAÇ, Adnan TÜFEK, Lütfi YAVUZ, Hüseyin VURAL, Osman GÖKALP

Evaluation of malaria cases in individuals after traveling to endemic regions of the world

Hülya ÇAŞKURLU, Emine PAKIR, Aslıhan ÇOLAK

Ocular surface culture changes in patients after septoplasty

Mahmut ÖZKIRIŞ, Zeliha KAPUSUZ GENCER, Çiğdem KADER, Levent SAYDAM

Incidental parathyroidectomy during thyroid surgery: risk factors, incidence, and outcomes

Bünyami ÖZOĞUL, Müfide Nuran AKÇAY, Abdullah KISAOĞLU

Increasing resistance of nosocomial Acinetobacter baumannii: are we going to be defeated?

Tümer GÜVEN, Gülruhsar YILMAZ, Hatice Rahmet GÜNER, Ayşe Kaya KALEM, Fatma ESER, Mehmet Akın TAŞYARAN

What is the best radiological method to predict the actual weight of the prostate?

Metin KILIÇ, Ahmet Tunç ÖZDEMİR, Serkan ALTINOVA, Ali Fuat ATMACA, Abdullah Erdem CANDA, Mevlana Derya BALBAY

Choroidal thickness in healthy Turkish subjects

Erol COŞKUN, Seydi OKUMUŞ, Bülent GÜRLER, Ramazan YAYUSPAYI, Burak ÖREN, Erdal KAYDU, Ayşegül ÇÖMEZ, İbrahim ERBAĞCI

Factors associated with the Pain Catastrophizing Scale and validation in a sample of the Turkish population

Mustafa SÜREN, İsmail OKAN, Aziz Mehmet GÖKBAKAN, Ziya KAYA, Ünal ERKORKMAZ, Semih ARICI, Serkan KARAMAN, Mürsel KAHVECİ

The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Oğuz EROĞLU, Süha TÜRKMEN, Ahmet MENTEŞE, Gökalp ALTUN, Süleyman TÜREDİ, Umut ERYİĞİT, Süleyman Caner KARAHAN, Abdülkadir GÜNDÜZ