Sami KINIKLI, Ali Pekcan DEMİRÖZ, Gülden BİLGİN, Şerife ALTUN, Çiğdem HATİPOGLU ATAMAN, Cemal BULUT

2114

An investigation of pulmonary findings of Crimean Congo haemorrhagic fever patients

An investigation of pulmonary findings of Crimean Congo haemorrhagic fever patients

Aim: Crimean Congo haemorrhagic fever (CCHF) generally affects many organs. In this study a retrospective evaluation of the pulmonary findings of CCHF patients was made. Materials and methods: The records of patients were retrospectively analysed. For each patient an evaluation was made of age, sex, occupation, place of residence, contact with ticks, smoking history, and pulmonary radiological and laboratory findings. A confirmed diagnosis of CCHF was made on determination by enzyme-linked immunosorbent assay or polymerase chain reaction. Results: Of the 128 patients, 48.4% were female. Symptoms of coughing were determined in 18% of patients, sputum in 4.7%, chest pain in 3.9%, dyspnoea in 3.1%, and haemoptysis in 0.8%. The mortality rate was 7%. In terms of sex, place of residence, contact with ticks, smoking, findings of the respiratory system, and physical examination findings, no statistically significant difference was seen between the survivor and nonsurvivor groups (P > 0.05). The white blood cell count values of the survivors were determined to be significantly lower compared to those of the nonsurvivors and the alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatine phosphokinase, and C-reactive protein values of the nonsurvivors were significantly higher compared to those of the survivors (P < 0.05). Conclusion: CCHF can be fatal for the respiratory system. An early diagnosis of CCHF and referral to a specialised centre is therefore important.
PDF

___

  • 1. Örmen B, Türker N, Ural S, El S, Kaptan F, Vardar Ç, Coşkun NA. Five cases of Crimean-Congo haemorrhagic fever from Western Anatolia, Turkey. Klimik J 2010; 23: 116–9 (in Turkish with English abstract).
  • 2. Kara A. Crimean–Congo haemorrhagic fever. Turk Pediatr J 2006; 49: 175–84.
  • 3. Ergönül ö. Crimean-Congo haemorrhagic fever (CCHF) in Turkey: a zoonosis which can cause nosocomial infection: invited commentary. Turkiye Klinikleri J Med Sci 2008; 28: 677–9.
  • 4. Wolfel R, Paweska JT, Petersen N, Grobbelaar AA, Leman PA, Hewson R, Georges-Courbot MC, Papa A, Günther S, Drosten C. Virus detection and monitoring of viral load in CrimeanCongo haemorrhagic fever virus patients. Emerg Infect Dis 2007; 13: 1097–100.
  • 5. Öztürk Engin D, Şengöz İnan A, Erdem İ, Ceran N, Altınaş J, Özyürek S, Karagül E, Göktaş P. Crimean-Congo haemorrhagic fever: evaluation of eight cases. Turk J Infection 2009; 23: 105– 8.
  • 6. Whitehouse CA. Crimean-Congo haemorrhagic fever. Antiviral Res 2004; 64: 145–60.
  • 7. Sumer A. The evaluation of the patients who were admitted to the emergency department of Kaş State Hospital because of tick biting. Kafkas Üniv Vet Fak Derg 2010; 16: 49–53 (in Turkish with English abstract).
  • 8. Kartı SS. Crimean-Congo haemorrhagic fever. Proceedings of the National Congress of Haematology, Antalya; 2009: 109–14 (in Turkish).
  • 9. Bakir M, Ugurlu M, Dokuzoguz B, Bodur H, Tasyaran MA, Vahaboglu H. Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures. J Med Microbiol 2005; 54: 385–9.
  • 10. Yilmaz GR, Buzgan T, Torunoglu MA, Safran A, Irmak H, Com S, Uyar Y, Carhan A, Ozkaya E, Ertek M. A preliminary report on Crimean-Congo haemorrhagic fever in Turkey. Eurosurveillance 2008; 13: 18953.
  • 11. Gunes T, Engin A, Poyraz O, Elaldi N, Kaya S, Dokmetas I, Bakir M, Cinar Z. Crimean-Congo haemorrhagic fever virus in high-risk population, Turkey. Emerg Infect Dis 2009; 15: 461–4.
  • 12. Maltezou HC, Andonova L, Andraghetti R, Bouloy M, Ergonul O, Jongejan F, Kalvatchev N, Nichol S, Nisdrig M, Platonov A et al. Crimean-Congo haemorrhagic fever in Europe: current situation calls for preparedness. Eurosurveillance 2010; 15: 19504.
  • 13. Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S. The clinical pathology of Crimean-Congo haemorrhagic fever. Clin Infect Dis 1989; 11: 794–800.
  • 14. Çilingiroğlu N, Temel F, Altıntaş H. Public’s knowledge, opinions and behaviors about Crimean-Congo haemorrhagic fever: an example from Turkey. Kafkas Üniv Vet Fak Derg 2010; 16: 17–22.
  • 15. Ergönül O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis 2006; 6: 203–14.
  • 16. World Health Organization (WHO). Joint Inter-country Workshop on CCHF: CCHF case definition criteria, Istanbul, Turkey. Geneva: WHO; 2006.
  • 17. Dogan OT, Engin A, Salk I, Epozturk K, Eren SH, Elaldi N, Bakir M, Dokmetas I, Akkurt I. Evaluatıon of respiratory findings in Crimean-Congo haemorrhagic fever. Southeast Asian J Trop Med Public Health 2011; 42: 1100–5.
  • 18. Watts DM, Ksiasek TG, Linthicum KJ, Hoogstraal H. CrimeanCongo haemorrhagic fever. In: TP Monath, editor. The Arboviruses: Epidemiology and Ecology, Vol. 2. Boca Raton, FL, USA: CRC Press; 1988. pp. 177–260.
  • 19. Schwarz TF, Nsanze H, Ameen AM. Clinical features of Crimean-Congo haemorrhagic fever in the United Arab Emirates. Infection 1997; 25: 364–7.
  • 20. Taşkesen M, Okur N, Taş MA. The evaluation of 19 patients who were admitted for the tick bite. Dicle Tıp Dergisi 2008; 35: 110–3 (in Turkish with abstract in English).
  • 21. Edlow JA, McGillicuddy DC. Tick paralysis. Infect Dis Clin North Am 2008; 22: 397–413.
  • 22. Mardani M, Keshtkar-Jahromi M. Crimean-Congo haemorrhagic fever. Arch Iranian Med 2007; 10: 204–14.
  • 23. Schnittler HJ, Feldmann H. Viral haemorrhagic fever - a vascular disease? Thromb Haemost 2003; 89: 967–72.
  • 24. Feldman H, Jones S, Klenk HD, Schnittler HJ. Ebola virus: from discovery to vaccine. Nat Immunol 2003; 3: 677–85.
  • 25. Doganci L. New insights on the bleeding disorders in CCHF. J Infect 2007; 55: 379–81.
  • 26. Tanir G, Tuygun N, Balaban I, Doksoz O. A case of CrimeanCongo haemorrhagic fever with pleural effusion. Jpn J Infect Dis 2009; 62: 70–2.
  • 27. Abadoglu O, Engin A. The frequency of self-reported allergic diseases in patients with Crimean-Congo haemorrhagic fever. Allergol Immunopathol 2009; 37: 234–8.
  • 28. Dilber E, Cakir M, Acar EA, Orhan F, Yaris N, Bahat E, Okten A, Erduran E. Crimean–Congo haemorrhagic fever among children in north-eastern Turkey. Ann Trop Paediatr 2009; 29: 23–8.
  • 29. Doganci L, Ceyhan M, Tasdelen NF, Sarikayalar H, Tulek N. Crimean-Congo haemorrhagic fever and diffuse alveolar hemorrhage. Trop Doct 2008; 38: 252–4.
  • 30. Sannikova IV, Pacechnikov VD, Maleev VV. Respiratory lesions in Crimean-Congo haemorrhagic fever. Ter Arkh 2007; 79: 20–3.
  • 31. Cheah FK, Sheppard MN, Hansell DM. Computed tomography or diffuse pulmonary haemorrhage with pathological correlation. Clin Radiol 1993; 481: 89–93.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Evaluation of outer hair cell function and medial olivocochlear efferent system in patients with type II diabetes mellitus

Hayriye KARABULUT, İsmail KARABULUT, Muharrem DAĞLI, Yıldırım Ahmet BAYAZIT, Şule BİLEN, Yusuf AYDIN, Serdar GÜLER, İsmet BAYRAMOĞLU

Urinary tract infection in patients with chronic kidney disease

Chih-yen HSIAO, Hsing-lin LIN, Yen-ko LIN, Chao-wen CHEN, Yuan-chia CHENG, Wei-che LEE, Tzu-chin WU

Indoor air quality in primary schools in Keçiören, Ankara

Mustafa Alparslan BABAYİĞİT, Bilal BAKIR, Ömer Faruk TEKBAŞ, Recai OĞUR, Abdullah KILIÇ, Serdar ULUS

Epistaxis in geriatric patients

Alper YÜKSEL, Hanifi KURTARAN, Ekrem Said KANKILIÇ, Nebil ARK, Kadriye Şerife UĞUR, Mehmet GÜNDÜZ

PUVA phototherapy-induced secondary amyloidosis in patients with mycosis fungoides: a rare adverse effect of phototherapy

İtır Ebru ZEMHERİ, Sıdıka Şeyma ÖZKANLI, İlkin ZİNDANCI, Serkan ŞENOL, Özge AKBULAK, Filiz Topaloğlu DEMİR

PUVA phototherapy-induced secondary amyloidosis in patients with mycosis fungoides: a rare adverse effect of phototherapy Itır

Ebru ZEMHERİ, İlkin ZİNDANCI, Serkan ŞENOL, Filiz DEMİR2TOPALOĞLU, Özge AKBULAK, Sıdıka Şeyma ÖZKANLI

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Alpaslan COŞAR, Osman Metin İPÇİOĞLU, Ömer ÖZCAN, Mustafa GÜLTEPE

Increasing resistance of nosocomial Acinetobacter baumannii: are we going to be defeated?

Tümer GÜVEN, Gülruhsar YILMAZ, Hatice Rahmet GÜNER, Ayşe Kaya KALEM, Fatma ESER, Mehmet Akın TAŞYARAN

Is perioperative examination of frozen sections necessary in nephron-sparing surgery?

Mehmet KALKAN, Soner YALÇINKAYA, Coşkun ŞAHİN, Yeşim ÜÇKURT, Ömer ETLİK

Prognostic value of neutrophil/lymphocyte ratio in patients with pulmonary embolism

Umut Yücel ÇAVUŞ, Sinan YILDIRIM, Ertan SÖNMEZ, Çağatay ERTAN, Özcan ÖZEKE