Nadia M. MOSIICHUK, Ivan V. MAKSYMIV, Viktor V. HUSAK, Janet M. STOREY, Kenneth B. STOREY, Volodymyr I. LUSHCHAK

Effect of Prometryn-Containing Herbicide Gesagard on Hematological Profiles and Biochemical Parameters in Goldfish Liver and Plasma

The impact of goldfish exposure for 96 h to herbicide Gesagard 500 FW at concentrations 0.2, 1, or 5 mg L−1(corresponding to 0.1, 0.5 or 2.5 mg L-1 of effective compound prometryn) on the hematological profile of blood andbiochemical parameters of plasma and liver was studied. Fish exposure to low concentration of the herbicide (0.2 mg L-1)slightly decreased liver glycogen and plasma lactate levels. Plasma glucose levels rose by 27% in goldfish exposed to 1 mg L-1 Gesagard. The activity of lactate dehydrogenase decreased by 63% and 36% in plasma of fish exposed to herbicide atconcentrations 1 and 5 mg L-1, respectively, but was not affected in liver.Goldfish exposure to the highest concentration of Gesagard (5 mg L-1) decreased hematocrit by 23% and increasedmonocyte count by 57%, and elevated triacylglycerol level by 91% in plasma. Overall, the results indicate that acute exposureto Gesagard induced minor changes in the hematological and biochemical parameters of goldfish, suggesting that disruptionsof these parameters may provide early warning signs that could be useful for assessing acute or sublethal toxic effects ofpesticides on aquatic species.

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