The aim of the present study was to examine comparative effects of different concentrations of heavy metals such ascadmium (Cd), cobalt (Co), lead (Pb) and mercury (Hg) on catfish oocyte maturation and ovulation. Post-vitellogenic oocytesof the catfish H. fossilis were incubated with heavy metals at concentrations of 0.1, 1.0, 10 and 50ng/ml. Translucent follicleswithout germinal vesicle and opaque follicles with GV were scored after 4, 8, 16, and 24 h of incubation. Percentage GVbreakdown (GVBD) was calculated as an index of oocyte maturation. The results of present investigation suggested that theeffect of heavy metals on oocyte maturation and ovulation was in the order of Pb>Hg>Cd>Co. Pb and Hg showed significantincreases (P
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Abdelouahaba, N., Merglera, D., Takserb, L.,Vaniera, C.,St- Jeana, M., Baldwina, M., Spearc, P.A., & Chan, H.M. (2008). Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada). Environmental Research, 107, 380- 392.https://doi.org/10.1016/j.envres.2008.01.006
Avazeri, N., Denys, A., & Lefèvre, B. (2006). Lead cations affect the control of both meiosis arrest and meiosis resumption of the mouse oocyte in vitro at least via the PKC pathway. Biochimie, 88(11), 1823-1829. https://doi.org/10.1016/j.biochi.2006.04.011
Beyersmann, D., & Hechtenberg, S. (1997). Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells. Toxicology and Applied Pharmacology, 144, 247- 261.https://doi.org/10.1006/taap.1997.8125
Brown, V., Shurben, D., Miller, W.,& Crane, M. (1994). Cadmium toxicity to rainbow trout Oncorhynchus mykiss Walbaum and brown trout Salmo trutta L. over extended exposure periods. Ecotoxicology and Environmental Safety, 29, 38–46. https://doi.org/10.1016/0147-6513(94)90028-0
Caserta, D., Mantovani, A.,Marci, R., Fazi, A., Ciardo, F., La, R.C., Maranghi, F., & Moscarini M. (2011). Environment and women's reproductive health. Human Reproduction Update, 17, 418-433. https://doi.org/10.1093/humupd/dmq061
Chaube , R., Mishra, S., & Singh, R.K. (2010). In vitro effects of lead nitrate on steroid profiles in the postvitellogenic ovary of the catfish Heteropneustes fossilis. Toxicology in Vitro, 24 (7), 1899-1904. https://doi.org/10.1016/j.tiv.2010.07.021
Choe, S.Y., Kim, S.J., Kim, H.G., Lee, J.H., Choi, Y.H., Lee, H., & Kim, Y.H. (2003). Evaluation of estrogenicity of major heavy metals. Science of the Total Environment, 312, 15-21. https://doi.org/10.1016/S0048-9697(03)00190-6
Choubey, M., Chaube, R. & Joy, K.P. (2015). Toxic effects of lead nitrate Pb(NO3)2 on the testis in the catfish Heteropneustes fossilis. Pharmacologia 6(2),63-72. https://doi:10.5567/pharmacologia.2015.
Chowdhury, A. R., & Arora, U. (1982). Toxic effect of mercury on testes in different animal species. Indian Journal of Physiology and Pharmacology, 26, 246- 249.
Devlin, R.H., & Nagahama, Y. (2002). Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture, 208 (3-4), 191-364. https://doi.org/10.1016/S0044-8486(02)00057-1
Dyer, C.A. (2007). Heavy metals as endocrine disrupting chemicals. In: Gore AC, (Eds.), Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice. (pp.111-133). Totowa, NJ, Humana Press., 361pp
Foster, W.G. (1992). Reproductive toxicity of chronic lead exposure in the female cynomolgus monkey. Reproductive Toxicology, 6, 123-131. https://doi.org/10.1016/0890-6238(92)90113-8.
Goswami, S.V., & Sundararaj, B.I. (1971). In vitro maturation and ovulation of oocytes of the catfish, Heteropneustes fossilis (Bloch): effects of mammalian hypophyseal hormones, catfish pituitary homogenate, steroid precursors and metabolites, and gonadal and adrenocortical steroids. Journal of Experimental Zoology, 178, 467-478. https://doi: 10.1002/jez.1401780405
Gupta, R.K, Singh, J.M., Leslie, T.C., Meachum, S., Flaws, J.A. &Yao, H. H. (2010). Di-(2-ethylhexyl) phthalate andmono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro. Toxicology and Applied Pharmacology, 242, 224-230. https://doi.org/10.1016/j.taap.2009.10.011
Hsu, P., Hsu, C., Liu, M., Chen, L., & Guo Y.L. (1998). Lead-induced changes in spermatozoa function and metabolism. Journal of Toxicology and Environmental Health A, 55, 45-64. http://dx.doi.org/10.1080/009841098158610
Hwang, I.J., Kima, H.W., Kima, J.K., Leeb, Y.D. & Baeka, H. J. (2010). Estrogenicity of 4-nonylphenol and diethylstilbestrol on in vitro oocyte maturation of the dusky tripletooth goby, Tridentiger obscurus. Animal Cells and Systems, 14(3), 161-167. http://dx.doi.org/10.1080/19768354.2010.504339
Jolibois, L.S.Jr, Shi, W.,George, W.J., Henson, M.C., &Anderson, M., (1999a). Cadmium accumulation and effects on progesterone release by cultured human trophoblast cells. Reproductive toxicology, 13, 215- 221. https://doi.org/10.1016/S0890-6238(99)00009-X
Jolibois, L.S.Jr.,Burrow, M.E., Swan, K.F., George, W.J., Anderson, M., & Henson, M.C., (1999b). Effects of cadmium on cell viability, trophoblastic development, and expression of low density lipoprotein receptor transcript in cultured human placental cells. Reproductive toxicology, 13, 1081-1084. https://doi.org/10.1016/S0890-6238(99)00041-6
Junaid, M., Chowdhuri, D.K., Narayan R., Shanker, R., & Saxena, D. K. (1997). Lead-induced changes in ovarian follicular development and maturation in mice. Journal of Toxicology and Environmental Health A, 50, 31-40. http://dx.doi.org/10.1080/009841097160582
Kasperczyk, A., Kasperczyk, S., Horak, S., Ostalowska, A., Grucka-Mamczar, E., Romuk, E., Olejek, A., &Birkner, E. (2008). Assessment of semen function and lipid peroxidation among lead exposed men. Toxicology and Applied Pharmacology, 228, 378-384. https://doi.org/10.1016/j.taap.2007.12.024
Khillare, K., Khillare, Y.K., & Wagh, W. (2017). Histological changes in gonads of fresh water fishes due to heavy metal pollution. World Journal of Pharmacy and Pharmaceutical Sciences. 6(7), 601- 609 . https://doi.org/10.20959/wjpps20177-8743
Kleiss-San, F.,& Schuetz, A. W., (1987). Sources of calcium and the involvement of calmodulin during steroidogenesis and oocyte maturation in follicles of Rana pipiens.Journal of Experimental Zoology, 244(1), 133- 143.https://doi.org/10.1002/jez.1402440116
Kondoh, M., Araragi, S., Sato, K., Higashimoto, M., Takiguchi, M., & Sato, M. (2002). Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology, 170 (1–2), 111-117. https://doi.org/10.1016/S0300-483X(01)00536-4
Lafuente, A., Cano, P., & Esquifino, A.I. (2003). Are cadmium effects on plasma gonadotropins, prolactin, ACTH, GH and TSH levels, dose-dependent? Biometals, 16, 243pp. https://doi.org/10.1023/A:1020658128413
Leoni, G., Bogliolo, L., Deiana, G., Berlinguer, F., Rosati, I., Pintus, P.P, Naitana, S., (2002). Influence of cadmium exposure on in vitro ovine gamete dysfunction. Reproductive Toxicology, 16(4), 371– 377. https://doi.org/10.1016/S0890-6238(02)00040-0
Łuszczek-Trojnar, E., Drąg-Kozak, E., Szczerbik, P., Socha, M., & Popek, W. (2014). Effect of long-term dietary lead exposure on some maturation and reproductive parameters of a female Prussian carp (Carassius gibelio B.) Environmental Science and Pollution Research, 21, 2465-2478. https://doi.org/10.1007/s11356-013-2184-x
Łukjanienko W.J. 1974. Toksykologia ryb. PWRiL, Warszawa. Massanyi, P., Uhrin, V., Sirotkin, A.V., Paksy, K., Forgács, Z. S., Toman, R., & Kovacik, J. (2000). Effects of cadmium on ultrastructure and steroidogenesis in cultured porcine ovarian granulosa cells. Acta Veterinaria Brno, 69, 101-106. https://doi.org/10.2754/avb200069020101
Massanyi, P., Uhrin, V., Toman, R., Kovacik, J., & Biro, D. (1999). Histological changes in the oviduct of rabbits after administration of cadmium, Journal of Animal Feed Science, 8, 255- 261.https://doi.org/10.22358/jafs/68933/1999
Mondal, S., Mukhopadhyay, B. & Bhattacharya, S. (1997). Inorganic mercury binding to fish oocyte plasma membrane induces steroidogenesis and translatable messenger RNA synthesis. BioMetals, 10, 285-290. https://doi.org/10.1023/A:1018372332624
Mukherjee, D., Kumar, V., & Chakraborti, P. (1994). Effect of mercuric chloride and Cd chloride on gonadal function and its regulation in sexually mature common carp Cyprinus carpio. Biomedical and Environmental Science, 7(1), 13-24. (PMID:8024715)
Nagahama, Y., Yoshikuni, M.,Yamashita, M., & Nagahama, Y. (1994). Regulation of oocyte maturation in fish. In: Sherwood N.M, Hew C.L., Parrell A.P., Randall D.J. (eds.): Fish Physiology: Molecular Endocrinology of Fish. New York, 13, 393-439. https://doi.org/10.1016/S1546- 5098(08)60074-6
Nagahama, Y. &Yamashita, M. (2008). Regulation of oocyte maturation in fish. Development and Growth Differentiation 50: S195-S219. https://doi.org/10.1111/j.1440-169X.2008.01019.x
Nagahama, Y., (1997). 17α, 20β-dihydroxy-4-pregnen-3– one, a maturation–inducing hormone in fish oocytes: mechanism of synthesis and action. Steroids, 62, 190- 196. https://doi.org/10.1016/S0039-128X(96)00180-8
Nampoothiri L.P., & Gupta, S. (2006). Simultaneous effect of lead and cadmium on granulosa cells: a cellular model for ovarian toxicity. Reproductive Toxicology, 21, 179-185. https://doi.org/10.1016/j.reprotox.2005.07.010
Nandi, S., Gupta, S.P., Selvaraju, S., Roy, S.C. & Ravindra, J.P. (2010). Effects of exposure to heavy metals on viability, maturation, fertilization, and embryonic development of Buffalo (Bubalus bubalis) oocytes in vitro. Archives of Environmental Contamination and Toxicology, 58 (1), 194. https://doi.org/10.1007/s00244-009-9342-7
Olsson, P.E., Kling, P., Petterson, C., & Silversand, C. (1995). Interaction of cadmium and oestradiol-17 beta onmetallothionein and vitellogenin synthesis in rainbow trout (Oncorhynchus mykiss). Biochemical Journal, 307, 197–203. https:// doi.org/ 10.1042/bj3070197
Paksy, K., Varga, B., Náray, M., Olajos, F., & Folly, G. (1992). Altered ovarian progesterone secretion induced by cadmium fails to interfere with embryo transport in the oviduct of the rat. Reproductive Toxicology, 6, 77-83.https://doi.org/10.1016/0890- 6238(92)90024-N
Patra, R. C., Swarup, D., Sharma, M. C., & Naresh, R. (2006). Trace mineral profile in blood and hair from cattle environmentally exposed to lead and cadmium around different industrial units. Journal of Veterinary Medicine A, Physiology, Pathology, Clinical Medicine, 53(10), 511- 517.https://doi.org/10.1111/j.1439-0442.2006.00868.x
Powlin, S. S., Keng, P. C., & Miller, R. K. (1997). Toxicity of cadmium in human trophoblast cells (JAr choriocarcinoma): Role of calmodulin and the calmodulin inhibitor, zaldaride maleate. Toxicology and Applied Pharmacology, 144, 225-234. https://doi.org/10.1006/taap.1997.8135
Romani , F., Tropea, A., Scarinci, E., Federico, A., Russo, C. D., Lisi, L. & Catino, S. (2014). Endocrine disruptors and human reproductive failure: the in vitro effect of phthalates on human luteal cells. Fertilityand Sterility, 102(3), 831-837. https://doi.org/10.1016/j.fertnstert.2014.05.041
Singhal, R.L., Nijayvargiya, R. & Shukla, G.S. (1985). Toxic effects of cadmium and lead on reproductive functions. In: Thomas, J.A., Korach, K.S., McLachlan, J.A. (Eds.), Target Organ Toxicology Series: Endocrine Toxicology, (pp-149-180). New York, Raven Press.
Smida, A.D., Valderrama, X.P., Agostini, M.C., Furlan, M.A., & Chedrese, J. (2004). Cadmium stimulates transcription of the cytochrome p450 side chain cleavage gene in genetically modified stable porcine granulosa cells. Biology of Reproduction, 70, 25- 31.https://doi.org/10.1095/biolreprod.103.019000
Sprocati, A.R., Alisi, C., Segre, L., Tasso, F., Galletti, M., & Cremisini, C. (2006). Investigating heavy metal resistance, bioaccumulation and metabolic profile a metallophile microbial consortium native to an abandoned mine. Science of Total Environment, 366, 649-658. https://doi.org/10.1016/j.scitotenv.2006.01.025
Srivastava, V., Dearth, R.K., Hiney, J.K., Ramirez, L.M., Bratton, G.R., & Dees, W.L. (2004). The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. Toxicological Sciences, 77, 35- 40.https://doi.org/10.1093/toxsci/kfg249
Szczerbik, P., Mikołajczyk, T., Sokołowska-Mikołajczyk, M., Socha, M., Chyb, J., & Epler, P. (2006) Influence of long-term exposure to dietary cadmium on growth, maturation and reproduction of goldfish (subspecies: Prussian carp Carassius auratus gibelio B.). Aquatic Toxicology, 77(2), 126–135. https://doi.org/10.1016/j.aquatox.2005.11.005
Szczerbik, P., Mikołajczyk, T., Sokołowska-Mikołajczyk, M., Socha, M., Chyb, J., & Epler, P. (2008). The influence of cadmium on Prussian carp oocyte maturation, development of eggs and hatching. Czech Journal of Animal Sciences, 53(1), 36-44.
Taupeau, J., Poupon, F., Nomé, B. & Lefèvre, (2001). Lead accumulation in the mouse ovary after treatmentinduced follicular atresia. Reproductive Toxicology, 15, 385-391. https://doi.org/10.1016/S0890- 6238(01)00139-3
Thomas P. (1993). Effect of cadmium on gonadotropin secretion from Atlantic croaker pituitaries incubated in vitro. Marine and Environment Research, 35, 141- 145. https://doi.org/10.1016/0141-1136(93)90028-X
Thomas, P., Baer, K. N., & White, R. B. (1994). Isolation and partial characterization of metallothionein in the liver of the red-eared turtle (Trachemys scripta) following intreperitoneal administration of cadmium. Comparative and Biochemical Physiology Part C. Pharmacol., 107(2), 221- 226.https://doi.org/10.1016/1367-8280(94)90044-2
Trant, J.M.,& Thomas, P. (1988). Structure-activity relationships of steroids in inducing germinal vesicle breakdown of Atlantic croaker oocyte in vitro. General and Comparative Endocrinology, 71, 307- 317. https://doi.org/10.1016/0016-6480(88)90259-6
Tsang, B.K., & Carnegie, J.A. (1983). Calcium requirement in the gonadotrophic regulation of rat granulosa cell progesterone production. Endocrinology, 113, 763- 769.https://doi.org/10.1210/endo-113-2-763
Tsang, B.K., & Carnegie, J.A. (1984). Calcium dependent regulation of progesterone production: effects of the calcium ionophore A23187, prostaglandin E2, dlisoproterenol and cholera toxin. Biology of Reproduction, 30(4), 787-794. https://doi.org/10.1095/biolreprod30.4.787
Van Der Kraak, G. (1991). Role of calcium in the control of steroidogenesis in preovulatory ovarian follicles of the goldfish. General and Comparative Endocrinology, 81, 268-275.https://doi.org/10.1016/0016- 6480(91)90011-T
Veldhuis, J.D., & Klase, P.A. (1982). Mechanisms by which calcium ions regulate the steroidogenic actions of luteinizing hormone in isolated ovarian cells in vitro. Endocrinology, 111, 1-6.https://doi.org/10.1210/endo- 111-1-1
Wide, M., (1985). Pb exposure on critical days of fetal life affects fertility in the female mouse. Teratology, 32, 375-380.https://doi.org/10.1002/tera.1420320307
Yang, M.Q., Xu, D., & Wang, F. (2004). Effect of several kinds of trace elements on meiotic maturation and in vitro fertilization on mouse oocyte. Animal Biotechnology Bulletin, 9, 444-448.
Zhang, W., & Jia, H. (2007). Effect and mechanism of cadmium on the progesterone synthesis of ovaries. Toxicology, 239, 204-212. https://doi.org/10.1016/j.tox.2007.07.007
Zhang, X.F., Zhang, L.J., Li, L., Feng, Y.N., Chen, B., Ma, J.M., & Shen, W. (2013). Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse. Environmental and Molecular Mutagenesis, 54, 354- 361,https://doi.org/10.1002/em.21776
Zhu, X., Kusaka, Y., Sato, K., & Zhang, Q. (2000). The Endocrine Disruptive Effects of Mercury. Environmental Health Prevention Medicine, 4, 174- 183,https://doi.org/10.1007/BF02931255