Synthesis and Antimicrobial Activity of Some New 3-Substituted Benzyl-5-(4-chloro-2-piperidin-1yl-thiazole-5-yl-methylene)-thiazolidine-2,4-dione Derivatives
A new series of thiazolyl thiazolidine-2,4-dione (Va-f) were synthesized and their structures were elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds Va-b, Vd-f showed high activity against Escherichia coli comparable to ampicillin.
Synthesis and Antimicrobial Activity of Some New 3-Substituted Benzyl-5-(4-chloro-2-piperidin-1yl-thiazole-5-yl-methylene)-thiazolidine-2,4-dione Derivatives
A new series of thiazolyl thiazolidine-2,4-dione (Va-f) were synthesized and their structures were elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds Va-b, Vd-f showed high activity against Escherichia coli comparable to ampicillin.
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- F.C. Brown, Chem. Rev. 61, 463-521 (1961).
- M.C.A. DeLima, D.L.B. Costa, A.J.S. Goes, S.L. Galdino, I.R. Pitta and C. Luu-Duc, Pharmazie 47, 182-184 (1992).
- M. Strumvoll and H.U. Haring, Ann. Med. 34: 217-222 (2002).
- O. Bozda˘g-D¨undar, E.J. Verspohl, A. Waheed and R. Ertan, Arzneim.-Forsch./Drug Res. 53, 831-836 (2003).
- A. Andreani, M. Rambaldi, A. Locatelli, R. Leoni, M. Bossa, I. Chiericozzi, G. Galatulas and A. Salvatore, Eur. J. Med. Chem. 28, 825-829 (1993).
- S.A.H. El-Feky, Pharmazie 48, 894-896 (1993).
- P.C. Unangst, D.T. Connor, W.A. Cetenko, R.J. Sorenson, J.C. Sircar, C.D. Wright, D.J. Schrier and R.D. Dyer, Bioorg. Med. Chem. Lett. 3, 1729-1734 (1993).
- R.C. Sup, R.Y. Sup and C.W. Bang, Korean J. Med. Chem. 5, 72-75 (1995).
- N. Agarwal, S. Kumar, A.K. Srivastava and P.C. Sarkar, Ind. J. Het. Chem. 6, 291-294 (1997).
- I.M. Labouta, H.M. Salama, N.H. Eshba, O. Kader and E. El-Chrbini, Eur. J. Med. Chem. 22, 485-489 (1987).
- S. Athmani, M. F. Farhat, B. and J. Iddon, Chem. Soc. Perkin Trans. 1, 973-977 (1992).
- N. Debski, W. Hanefeld and M. Schlitzer, J. Heterocyclic Chem. 34, 1427-1429 (1997).
- C. Lo and E.Y. Shropshire, J. Org. Chem. 22, 999-1001 (1957).
- D.L.B. Costa, J. Chantarel, M.C. Alves DeLima, J.F.C. Albuquerque, R.M.O. Lima, S.L. Galdino, I.R. Pitta and C. Luu-Duc, J. Pharm. Belg. 50, 5-10 (1995).
- A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. Clin. Pathol. 45, 493-496 (1966).