U. M. Dhana LEKSHMI, P. Neelakanta REDDY

Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides

Evolvulus alsinoides L. (Convolvulaceae) tüm bitkisinin etanolik özütü, dişi albino sıçanlarda antiinflamatuar, antipiretik ve antidiyare özellikleri bakımından araştırıldı. Bitki özütündeki aktif kimyasal bileşenlerinin varlığını doğrulamak için ön "tokimyasal çalışmalar yapıldı ve sonuç flavonoidlerin, alkaloidlerin ve kardiyak glikozitlerin varlığına dair olumlu bir rapor gösterdi. Farmakolojik sonuç, vücut ağırlığının 250 mg/kg ve 500 mg/kg dozundaki etanolik özütün sıçanlarda karajenle teşvik edilen sıçan ayak ödemi inhibisyonuna önemli ölçüde (P < 0,05) ve bira mayasıyla teşvik edilen hiperpireksinin azalmasına önemli ölçüde (P < 0,05) neden olduğunu gösterdi. Ayrıca özüt, 500 mg/kg dozda hint yağıyla teşvik edilen diyareye karşı antidiyarel aktiviteyi belirgin şekilde ortaya çıkardı. Bu çalışma; antiinflamatuar, antipiretik ve antidiyare aktiviteleri bakımından tüm Evolvulus alsinoides bitkisi hakkındaki atasal iddiayı bilimsel olarak kanıtlamıştır.

Evolvulus alsinoides’un antiin!amatuar, antipiretik ve antidiyare özellikleri üzerine ön çalışmalar

The ethanolic extract of the whole plant of Evolvulus alsinoides L. (Convolvulaceae) was investigated for antiinflammatory, antipyretic and antidiarrhoeal properties in female albino rats. Preliminary phytochemical studies were carried out to con"rm the presence of active chemical constituents in the plant extract, and the result showed a positive report for the presence of $avonoids, alkaloids and cardiac glycosides. The pharmacological result showed that the ethanolic extract at a dose of 250 mg/kg body weight and 500 mg/kg body weight caused a signi"cant (P < 0.05) inhibition of the carrageenan-induced rat paw oedema and a signi"cant (P < 0.05) reduction of hyperpyrexia induced by Brewer’s yeast in rats. The extract also elicited marked antidiarrhoeal activity against castor oil-induced diarrhoea at a dose of 500 mg/kg. Tis study has proved scienti"cally the ancient claim that the whole plant of Evolvulus alsinoides has antiinflammatory, antipyretic and antidiarrhoeal activities.

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