Halopridolün Sıçanlarda Çevresel Uyaranlar Tarafından Kontrol Edilen Pedala Basma Davranışı Üzerindeki Etkileri

Bu araştırmada bir dopamin (DA) D2 reseptör antagonisti olan haloperidolün (0.00, 0.08, 0.16 ve 0.32 mg/kg, ip) sıçanların gerçekleştirdikleri, su ile pekiştirilen pedala basma davranışı üzerindeki etkilerinin, davranışın pekiştirilip pekiştirilmediğine, davranışın deneyci tarafından değişimlenen ses ve ışık gibi çevresel uyaranlarca kontrol edilip edilmediğine ve uyaran türüne bağlı olarak farklılaşıp farklılaşmadığı incelenmiştir. Araştırmada kontrol (n~6), ışık (n= 8) ve ses (n = 7) grupları olmak üzere üç gruba ayrılan 21 adet erkek, albino Wistar sıçan denek olarak kullanılmıştır. Deneklere pekiştireç elde etmek için pedala basmaları öğretildikten sonra, deney gruplarının pedala basma davranışları ses veya ışık uyaranının kontrolü altına sokulmuş ve daha sonra her deneysel oturum için, ilaç etkisi altındaki deneklerin pedala basma davranışlarının pekiştirildiği (S+ koşulu) ve pekiştirilmediği (S- koşulu) koşullarda davranış ölçümleri alınmıştır. Her deneğin her bir deney oturumundaki performansını temsil eden ortalama S+ ve S- koşulu pedala basma sayısı değerleri ve her bir denek ve ilaç miktarı için S+ koşulunda yapılan davranış sayısının aynı denek tarafından aynı ilaç miktarı etkisi altında gerçekleştirilen toplam davranış sayısına bölünmesiyle elde edilen oran değerleri tekrat ölçümlü ANOVA ve eğilim analizleri kullanılarak analiz edilmiştir. Araştırmanın bulguları, DA D2 reseptörlerinin bloklanmasının deneklerin pedala basma davranışlarının sayısında azalmaya yol açmakla birlikte, davranışın çevresel uyaranlarca kontrolünü etkilemediğini göstermiştir.

Anahtar Kelimeler:

haloperidol, dopamin

Effects of Haloperidol on Cue Controlled Lever Pressing Behavior in the Rat

The current study examined whether the presence and absence of discrete environmental stimuli controlling water reinforced lever-pressing response could change the well known behavior attenuating effects of dopamine D2 receptor antagonist haloperidol (0.00, 0.08, 0.16 and 0.32 mg/kg, ip). 21 rats were trained to bar press to obtain water, and then, divided into three groups. One of the groups was the control group. Remaining two groups of rats were trained to bar press to Obtain water in the presence of either an auditory (sound group) or a visual cue (light group). The number of lever-pressing responses for the subjects were recorded in the presence (S+) and absence (S-) of environmental stimuli and reinforcer. Haloperidol suppressed the mean number of responses for all groups, regardless of stimulus conditions. However, the index of persistence obtained for each subject by dividing the number of responses emitted during the presence of respective envirohmental cue to the number of total responses executed by the same subject under the same conditions, remained the same after haloperidol pretreatment. The results showed that although haloperidol attenuated the number of operant lever-pressing responses, the conditioned motivational properties of environmental cues are unaltered by treatment with the same D2 receptor antagonist.

Keywords:

haloperidol, dopamine,

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