Hiperbilirubinemili yenidoğanlarda farklı ışık yoğunluğundaki fototerapinin kardeş kromatid değişimi üzerine etkisi
Amaç: Fototerapide kullanılan yüksek etki gücüne sahip görünebilir ışığın in vitro olarak DNA zincir kırıkları ve DNA hasarının bir göstergesi olan kardeş kromatid değişimi sıklığını arttırdığı ve mutasyonlara yol açtığı bildirilmiştir. Bu çalışmanın amacı hiperbilirubinemi ve üç farklı fototerapi yönteminin kardeş kromatid değişiminin sıklığını araştırarak DNA hasarı üzerine etkisini değerlendirmektir. Gereç ve Yöntemler: Gebelik yaşı 37 haftadan büyük olan ve bilirubin değerleri fototerapi sınırı üzerinde olan hastalar üç gruba ayrıldı ve her gruba 25'er bebek alınması planlandı. Grup 1 güçlendirilmiş iki kutuplu lamba fototerapisi, grup 2 iki kutuplu lamba fototerapisi, grup 3 ise geleneksel fototerapi aldı. Hiperbilirubinemi saptanan ancak fototerapi gereksinimi olmayan bebekler kontrol grubuna alındı; bilirubin değeri
The effect of phototherapy on sister chromatid exchange with different light density in newborn hyperbilirubinemia
Aim: Concerns of possible genotoxic effects of hyperbilirubinemia and phototherapy were raised from experimental and observational studies in neonates. The purpose of this study was to assess the effect of hyperbilirubinemia and phototherapy with three different methods on DNA damage by investigating sister chromatid exchange frequency. Material and Methods: Patients whose gestational ages were >37 weeks and bilirubin levels above phototherapy limits were enrolled into three groups and each group was planned to receive 25 babies. Group
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