Murat ÖZEREN, Barlas Naim AYTAÇOĞLU, Mehmet Kerem KARACA, Rahime AKIN, Nehir SUCU

The decisive role of red cell distribution width in carotid endarterectomy patients

Amaç: Bu çalışmada, kırmızı hücre dağılım genişliğinin karotis arter hastalığında bağımsız bir kardiyovasküler risk faktörü olup olmadığı araştırıldı.Ça lış ma pla nı: Çalışmaya Haziran 2011 - Haziran 2014 tarihleri arasında Kuzey Amerika Semptomatik Karotis Endarterektomi Çalışması kriterlerine göre >=%50 karotis arter darlığı olan ve yakın zamanda geçici iskemik atak veya kısmen iyileşmiş serebrovasküler olay öyküsü olan 113 semptomatik hasta alındı. Hastalar tek başına günlük aktivitelerini yerine getirebiliyordu. Kontrol grubu bu kriterleri taşımayan 114 hastadan oluşuyordu. Tüm kan örnekleri, 12 saatlik açlığı takiben alındı. Çalışma grubu ve kontrollerin kırmızı hücre dağılım genişliği değerleri karşılaştırıldı. Ayrıca, çalışma grubunda kırmızı hücre dağılım genişliği değerlerinin kardiyovasküler risk faktörleri ve klinik özellikler açısından ilişkisi de değerlendirildi.Bul gu lar: Çalışma grubunda kırmızı hücre dağılım genişliği değerleri ve karotis arter darlığı arasında anlamlı bir fark bulunamadı. Çalışma grubunda kırmızı hücre dağılım genişliği değerleri, ameliyat öncesi ve ameliyat sonrası klinik özellikler açısından anlamlılığa ulaşmadı.So nuç: Yüksek kırmızı hücre dağılım genişliği değerleri altta yatan biyolojik veya metabolik dengesizlik nedeniyle ikinci semptom olarak düşünülebilmesine karşın, bağımsız bir kardiyovasküler risk faktörü olduğu sonucuna varmak için daha kapsamlı çalışmalara gereksinim vardır.

Kırmızı hücre dağılım genişliğinin karotis endarterektomi hastalarında belirleyici rolü

Background: This study aims to investigate whether the red cell distribution width is an independent cardiovascular risk factor for carotid artery disease.Methods: The study enrolled 113 symptomatic patients who had carotid artery stenosis >=50% according to the North American Symptomatic Carotid Endarterectomy Trial criteria with a history of a recent transient ischemic attack or partially recovered cerebrovascular accidents between June 2011 and June 2014. The patients were able to carry on with their daily activities on their own. The control group consisted of 114 patients who did not meet these criteria. All blood samples were obtained after 12 hours of fasting. The red cell distribution width values of the study group and the controls were compared. The red cell distribution width values were also assessed in terms of the possible relation with cardiovascular risk factors and clinical features in the study group.Results: There was no significant association between the red cell distribution width values and carotid artery stenosis in the study group. The red cell distribution width did not reach significance among the study patients with respect to the preoperative and postoperative clinical features.Conclusion: Although increased red cell distribution width values may be considered as an epiphenomenon due to an underlying biological or metabolic imbalance, it still necessitates further comprehensive studies to conclude that it is an independent cardiovascular risk factor for carotid artery disease.

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