Background: The results of the open heart surgery operations performed at our renovated university clinic were presented. Methods: A total of 129 patients (83 men, 46 women; mean age 48.75 years) underwent open heart surgery in our center between December 2006 and May 2007. The main operations were performed for coronary artery surgery to 83 (64.3%) patients. Four patients underwent off-pump coronary artery bypass graft (CABG) surgery. Other etiologies were: mitral valve disease (n=15), aortic valve disease (n=10), ascending aortic aneurysm (n=2), acute type A aortic dissection (n=2), atrial septal defect (n=13), tetralogy of Fallot (n=5) and patent ductus arteriosus (n=2). Most of the patients were referred from various clinics of our faculty. Therefore the rate of comorbidity incidence of the patient population is high. Major comorbidities were diabetes mellitus (n=35), goiter history (n=20), pulmonary hypertension (n=8), history of renal transplantation prior to cardiac surgery (n=3), active infective endocarditis (n=3), systemic lupus erythematosus (n=2) and von Willebrand's disease (n=l). Results: There were three in-hospital mortality (%2.3) in our patients. Coronary artery bypass grafting, total correction of tetralogy of Fallot and repair of Stanford Type A aortic dissection were the operations performed in these three patients. Major postoperative complications were detected in 11 patients (8.53%). Wound infections in three patients (2.3%), low cardiac output in two patients (1.5%), new onset renal insufficiency in two patients (1.5%), temporary neurologic disorder in two patients (1.5%). Complete atrioventricular block was observed in two patients and permanent pacemaker devices were inserted to both patients. Intra aortic balloon counterpulsation was used in two patients. There was no reoperation, perioperative myocardial infarction and mediastenitis. Conclusion: İstanbul University Cerrahpaşa School of Medicine restarted open heart surgery operations with a renovated intensive care unit and operation theaters since December 2006. Shortly after its renovation, we think that open heart surgery has been performed successfully despite of the high comorbid diseases.