Zekiye AYDOĞDU, Soner GÜRSOY, Arkın ACAR, Şeyda ÖRS KAYA, Sadık YALDIZ, Demet YALDIZ

Akciğer adenokarsinomunda papiller baskın histolojik alt tip sağkalımı kötü etkiler

Amaç: Bu çalışmada papiller baskın histolojik alt tipin akciğer adenokarsinomunda sağkalımı kötü etkileyip etkilemediği araştırıldı. Çalışma planı: Ocak 2005 - Aralık 2016 tarihleri arasında kliniğimizde ameliyat olan papiller baskın alt tipli akciğer adenokarsinomlu toplam 80 hasta (70 erkek, 10 kadın; ort. yaş 60.7 yıl; dağılım 42-79 yıl) çalışmaya alındı. Bu hastalar lepidik, asiner ve müsinöz alt tipler ile karşılaştırıldı. Genel ve beş yıllık sağkalım oranları değerlendirildi. Bulgular: Beş yıllık sağkalım papiller baskın histolojik alt tipte %40.5 iken, bu oran lepidik, asiner ve müsinöz alt tiplerde sırasıyla %70.9, %59.0 ve %66.6 idi. Papiller alt tipin sağkalımı lepidik (p=0.002), asiner (p=0.008) ve müsinöz (p=0.0048) alt tiplere kıyasla, anlamlı düzeyde daha kötü idi. Bu durum, Evre 1 hastalıkta daha belirgindi (papiller %47.5, lepidik: %86.9 [p=0.001], asiner %69.3 [p=0.040] ve müsinöz %90.0 [p=0.050]). Sonuç: Çalışma sonuçlarımız papiller baskın alt tipin akciğer adenokarsinomunda sağkalımı kötü etkilediğini ve bu olguların, hastalığın erken evrelerinde dahi, adjuvan tedavi yöntemleri için aday olabileceğini göstermektedir.

Papillary predominant histological subtype predicts poor survival in lung adenocarcinoma

Background: This study aims to investigate whether papillarypredominant histological subtype can predict poor survival inlung adenocarcinoma.Methods: Between January 2005 and December 2016,a total of 80 patients with papillary predominant subtype lungadenocarcinoma (70 males, 10 females; mean age 60.7 years;range, 42 to 79 years) operated in our clinic were included in thestudy. These patients were compared with those having lepidic,acinar, and mucinous subtypes. Overall and five-year survivalrates were evaluated.Results: Five-year survival was 40.5% in papillary predominanthistological subtype, while this rate was 70.9%, 59.0%, and66.6% in lepidic, acinar, and mucinous subtypes, respectively.Papillary subtype showed significantly poor survival comparedto lepidic (p=0.002), acinar (p=0.008), and mucinous subtypes(p=0.048). In Stage 1 disease, it was more evident (papillary,47.5%, lepidic 86.9% [p=0.001], acinar 69.3% [p=0.040], andmucinous 90.0% [p=0.050]).Conclusion: Our study results suggest that papillary predominantsubtype predicts poor survival in lung adenocarcinoma and thesecases may be candidates for adjuvant treatment modalities evenin the earlier stages of disease.

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