Nylon Sağlık Bölgesi hastanesine başvuran HIV/AIDS hastalarında Kandidiyazis; Douala-Kamerun

AMAÇ: Kandidiyazis HIV ve AIDS hastalarındaki önde gelen fırsatçı mantar enfeksiyonudur. YÖNTEM: Bu enfeksiyonun Nylon Sağlık Bölgesi\'nde, farklı CD4+ T hücre kategorilerindeki prevalansını saptamak üzere 304 HIV pozitif katılımcı arasında Mart-Ağustos 2007 tarihlerinde, kesitsel bir araştırma yapıldı. Hastalar yüksek düzeyde aktif antiretroviral tedavi (Highly active antiretroviral therapy: HAART) alan ve almayan olarak iki gruba ayrıldı. Ağız, vajinal-üretral sürüntü ve idrar olmak üzere her hastadan üç örnek alındı. BULGULAR: Toplam 204 hasta (%67.1, %95GA:%61.8-%72.4), kandidiyazis için riski artırıcı özelliklere sahipti, bunlardan en fazla görülen antibiyotik tedavisi alıyor olmak (%63.7) ve hamilelik (%7.3) idi. Kandidiyazis CD4+ T hücre sayısı 200\'ün altında olanlarda (%66), olmayanlardan (%17.9) daha yaygındı (p

[Candidiasis in HIV and AIDS patients attending the Nylon Health District Hospital in Douala, cameroon]

AIM: Candidiasis is the leading opportunistic mycosis in HIV and AIDS patients. METHOD: In order to determine its prevalence in patients with different CD4+ T cell categories in the Nylon Health District in Douala, a cross-sectional study was carried out whereby 304 HIV positive individuals were recruited between March and August, 2007. They were divided into two groups; those on highly active antiretroviral therapy (HAART) and those not on HAART. Three samples constituting mouth, vaginal/urethral swabs and urine were collected from each subject. RESULTS: A total of 204 (67.1%) [95% confidence interval (CI): 0.618-0.724] of these patients had more than one predisposing condition to candidiasis, with those on antibiotic therapy having the highest prevalence (63.7%) followed by pregnant patients (7.3%) (P < 0.05). Candidiasis was more common in patients with low CD4+ T cell count (<200) [66%] than patients with higher CD4+ T cell count (17.9% ) (P<0.05). One hundred and sixty one (53%) of the patients had candidiasis whereby those not on HAART were more frequently infected (69.6%) than those on HAART (30.1%) (p< 0.05). CONCLUSION: We conclude that candidiasis is a major opportunistic infection in HIV patients and should be checked especially in patients not yet on antiretroviral therapy.

Kaynakça

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