SERPİL OĞUZTÜZÜN, MURAT KILIÇ, Nisa TANDOĞAN, LATİF ÖZTÜRK, Yazıcı Zuhal GÖKBULUT

Endüstriyel kimyasallara maruz kalan işçilerin mesane kanserine yakalanma risklerinin değerlendirilmesi

AMAÇ: Bu çalışmanın amacı, Kırıkkale’de endüstriyel kimyasallara maruz kalan işçilerin, mesane kanserine yakalanma risklerini idrar sitolojisi yöntemiyle değerlendirmektir. YÖNTEM: Barut fabrikasında çalışan ve yaş ortalamaları 47±5 yıl olan 63 işçinin idrar sitolojisi örnekleri, Papanicalaou yöntemiyle hazırlanmış ve ışık mikroskobunda değerlendirilmiştir. Sitolojik inceleme sonucunda kişilerin kimyasallara maruz kalma süreleri ve PAP sonuçları arasındaki ilişki Varyans Analiz (ANOVA) metoduyla %95 güvenilirlik düzeyinde istatistiksel olarak değerlendirildi. BULGULAR: Altmışüç işçiden kimyasallara maruz kalmayan 16 kişilik kontrol grubunun sitopatolojisi negatiftir. Kimyasallara maruz kalma süreleri 20 yıl ve üzerinde olan 47 kişiden 2’sinde metaplazik hücreler ve iki işçinin idrar sitoloji örneklerinde displazik hücreler tespit edilmiştir. Ayrıca, 30 yıl ve üzeri çalışan bir işçide ise ürotel karsinom görüldü. SONUÇ: Çalışma ortamında kimyasallara maruz kalma süresinin artmasıyla, mesane kanserine yakalanma riskinin de arttığı istatistiksel olarak anlamlı bulundu (p

Evaluation of bladder carcinoma risk of the workers exposed to industrial chemicals

AIM: The aim of this study is to evaluate the ratios of bladder carcinoma of workers exposed to industrial chemicals in Kırıkkale, Turkey by urinary cytology method. METHOD: Urinary cytology preparations for a total of 63 workers in the gun powder production plant was prepared using Papanicolaou staining and evaluated by light microscopy. The relationship between Papanicolaou staining results and workers’ exposure time to chemicals was evaluated statistically by Post Hoc Test method. RESULTS: For the cytological diagnoses of voided urine in all 63 workers, 16 workers as control group had negative cytologic findings. 47 workers exposed to industrial chemicals more than 20 years had two metaplasic and two dysplasic cells in their urine cytology samples. Moreover, a worker exposed to industrial chemicals more than 30 years had urothelial carcinoma cells. CONCLUSİON: That the workers’ risk of developing bladder carcinoma increases with their exposure time to chemicals in their work environment has been found statistically significant (p<0,05).

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