Benzen ve sağlık etkileri

Benzen bir aromatik hidrokarbondur, renksiz, hoş kokulu bir sıvıdır. Önemli bir endüstriyel çözücüdür; plastik, deterjan, pestisid ve diğer kimyasalların üretiminde kullanılır. Benzen karsinojendir. Kısa süreli yüksek düzeyde benzen maruziyeti santral sinir sistemi semptomlarına neden olur. Uzun süreli benzen maruziyeti kemik iliği ve kan üretimini olumsuz etkileyebilir. Ayrıca, kronik benzen maruziyetiyle genotoksik, immunolojik ve ürogenital olumsuz etkilenmeler oluşabilir.

Anahtar Kelimeler:

Çevresel maruziyet, Risk faktörleri, Zararlı maddeler, Benzen, Toksik etkiler

Benzene and its health effects

Benzene is an aromatic hydrocarbon, colorless, sweet-smelling liquid. It is an important industrial solvent, is used in the manufacture of plastics, detergents, pesticides, and other chemicals. Benzene is a carcinogen. Short-term and high level benzene exposure causes symptoms of the central nervous system. Long-term benzene exposure may affect to bone marrow and blood production. Additionally, genotoxic, immunological, and urogenital negative effects may occur with chronicle benzene exposure.

Keywords:

Environmental Exposure, Risk Factors, Hazardous Substances, Benzene, Toxic Actions,

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1. Bilir N, Yıldız AN. İş Sağlığı ve Güvenliği. Ankara. Hacettepe Üniversitesi Yayınları, 2004, p. 199- 201.
2. Organik_Kimya_1_Hidrokarbonlar._ http://www.aof.anadolu.edu.tr/kitap/EHSM/1222/u nite14.pdf [Erişim tarihi: 02.03.2008].
3. Velicangil S. Koruyucu ve Sosyal Tıp. 2. Baskı. İstanbul. Filiz Kitabevi, 1980, p. 551-56.
4. Bilir N. İş Sağlığı. Eds.: Bertan M, Güler Ç. İç: Halk Sağlığı Temel Bilgileri. 2. Baskı. Ankara: Güneş Kitabevi Ltd. Şti, 1997, p. 274-75.
5. Chapter 5.2. Benzene. Air Quality Guidelines - Second Edition. WHO Regional Office for Europe, Copenhagen,_Denmark,_2000.http://www.euro.w ho.int/document/aiq/5_2benzene.pdf [Erişim tarihi: 02.03.2008].
6._Akdur_R._İşyerinde_toksinler.www.recepakdur.co m/getfile.asp?file=İŞYERİNDE%20TOKSİNLER% 20RA.pdf [Erişim tarihi: 02.03.2008].
7. Kalnas J, Teitelbaum DT. Dermal absorption of benzene: implications for work practices and regulations. Int J Occup Environ Health. 2000; 6(2): 114-21.
8. Yavuz Ö. Dış ortam hava kirliliğinin organizmada yarattığı etkilerin vücut sıvıları ve ekshale havada ölçümü._http://www.toraks.org.tr/pdf/hava_kir_se mp/invivo_olcumler.pdf_[Erişim_tarihi:_12.03.2008].
9. Daniell WE, Claypoole KH, Checkoway H, Smith- Weller T, Dager SR, Townes BD, et al. Neuropsychological function in retired workers with previous long-term occupational exposure to solvents. Occup Environ Med. 1999; 56(2): 93-105.
10. Yu IT, Lee NL, Zhang XH, Chen WQ, Lam YT, Wong TW. Occupational exposure to mixtures of organic solvents increases the risk of neurological symptoms among printing workers in Hong Kong. J Occup Environ Med. 2004; 46(4): 323-30.
11. Lee EH, Eum KD, Cho SI, Cheong HK, Paek do M._Acquired_dyschromatopsia_among_petroche mical industry workers exposed to benzene. Neurotoxicology. 2007;28(2):356-63.
12. Aktuğlu G. Aplastik anemi ve saf eritroid dizi aplazisi. İ.Ü. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi_Etkinlikleri._İstanbul._Anemiler_Sempozy umu. 2001, p. 87-9.
13. Aksoy M. Hematotoxicity and carcinogenicity of benzene. Environ Health Perspect. 1989; 82: 193-7.
14. Qu Q, Shore R, Li G, Jin X, Chen LC, Cohen B, et al. Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med. 2002; 42(4): 275-85.
15. Ray MR, Roychoudhury S, Mukherjee S, Lahiri T. Occupational benzene exposure from vehicular sources in India and its effect on hematology, lymphocyte subsets and platelet P selectin expression. Toxicol Ind Health. 2007; 23(3): 167- 75.
16. World Health Organization, International agency for research on cancer lists of IARC evaluations according to IARC monographs IARC, Lyon 1993._http://www.ilo.org/public/english/protection/ safework/cis/products/safetytm/iarclist.htm [Erişim tarihi: 18.03.2008].
17. Aksoy M, Erdem S, DinCol G. Leukemia in shoeworkers exposed chronically to benzene. Blood. 1974; 44(6): 837-41.
18. Yaris F, Dikici M, Akbulut T, Yaris E, Sabuncu H. Story of benzene and leukemia: epidemiologic approach of Muzaffer Aksoy. J Occup Health. 2004; 46(3): 244-7.
19. Infante PF, Rinsky RA, Wagoner JK, Young RJ. Leukaemia in benzene workers. Lancet. 1977; 2: 76–78.
20. Rinsky RA, Young RJ, Smith AB. Leukaemia in benzene workers. American journal of industrial medicine. 1981; 2: 217–245.
21. Rinsky RA, Smith AB, Hornung R, Filloon TG, Young RJ, Okun AH, et al. Benzene and leukaemia. An epidemiologic risk assessment. N Engl J Med. 1987; 316: 1044–1050.
22. Rinsky RA. Benzene and leukaemia: An epidemiologic risk assessment. Environmental health perspectives. 1989; 82: 189–191.
23. Paxton MB, Chinchilli VM, Brett SM, Rodricks JV. Leukaemia risk associated with benzene exposure in the pliofilm cohort: I. Mortality update and exposure distribution. Risk Anal. 1994; 14: 147–154.
24. Natelson EA. Benzene-induced acute myeloid leukemia: a clinician's perspective. Am J Hematol. 2007; 82(9): 826-30.
25. Schnatter AR, Rosamilia K, Wojcik NC. Review of the literature on benzene exposure and leukemia subtypes. Chem Biol Interact. 2005; 153-154: 9-21.
26. Guénel P, Imbernon E, Chevalier A, Crinquand- Calastreng A, Goldberg M. Leukemia in relation to occupational exposures to benzene and other agents: a case-control study nested in a cohort of gas and electric utility workers. Am J Ind Med. 2002; 42(2): 87-97.
27. Adegoke OJ, Blair A, Shu XO, Sanderson M, Jin F, Dosemeci M, et al. Occupational history and exposure and the risk of adult leukemia in Shanghai. Ann Epidemiol. 2003; 13(7): 485-94.
28. Li K, Yu S. Leukemia mortality and occupational exposure to rubber: a nested case control study. Int J Hyg Environ Health. 2002; 204(5-6): 317-21.
29. Swaen GM, Scheffers T, de Cock J, Slangen J, Drooge H. Leukemia risk in caprolactam workers exposed to benzene. Ann Epidemiol. 2005; 15(1): 21-8.
30. Seniori Costantini A, Quinn M, Consonni D, Zappa M. Exposure to benzene and risk of leukemia among shoe factory workers. Scand J Work Environ Health. 2003; 29(1): 51-9.
31. Aksoy M. Hematotoxicity and carcinogenicity of benzene. Environ Health Perspect. 1989; 82:193-7.
32. Sonoda T, Nagata Y, Mori M, Ishida T, Imai K. Meta-analysis of multiple myeloma and benzene exposure. J Epidemiol. 2001; 11(6): 249-54.
33. Kirkeleit J, Riise T, Bråtveit M, Moen BE. Increased risk of acute myelogenous leukemia and multiple myeloma in a historical cohort of upstream petroleum workers exposed to crude oil. Cancer Causes Control. 2008; 19(1): 13-23.
34. Collins JJ, Ireland B, Buckley CF, Shepperly D. Lymphohaematopoeitic cancer mortality among workers with benzene exposure. Occup Environ Med. 2003; 60(9): 676-9.
35. Smith MT, Jones RM, Smith AH. Benzene exposure and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007; 16(3): 385-91.
36. Miligi L, Costantini AS, Benvenuti A, Kriebel D, Bolejack V, Tumino R, et al. Occupational exposure to solvents and the risk of lymphomas.Epidemiology. 2006; 17(5): 552-61.
37. Lamm SH, Engel A, Byrd DM. Non-Hodgkin lymphoma and benzene exposure: a systematic literature review. Chem Biol Interact. 2005; 153- 154: 231-7.
38. Wong O, Fu H. Exposure to benzene and non- Hodgkin lymphoma, an epidemiologic overview and an ongoing case-control study in Shanghai. Chem Biol Interact. 2005; 153-154: 33-41.
39. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR, Fritschi L, et al. Leukemia risk associated with low-level benzene exposure. Epidemiology. 2003; 14(5): 569-77.
40. Chen R, Seaton A. A meta-analysis of painting exposure and cancer mortality. Cancer Detect Prev. 1998; 22(6): 533-9.
41. Krishnadasan A, Kennedy N, Zhao Y, Morgenstern H, Ritz B. Nested case-control study of occupational chemical exposures and prostate cancer in aerospace and radiation workers. Am J Ind Med. 2007; 50(5): 383-90.
42. Pan SY, Ugnat AM, Mao Y. Occupational risk factors for brain cancer in Canada. J Occup Environ Med. 2005; 47(7): 704-17.
43. Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occup Med (Lond). 2002; 52(3): 157-64.
44. Pesch B, Haerting J, Ranft U, Klimpel A, Oelschlägel B, Schill W. Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. Int J Epidemiol. 2000; 29(6): 1014-24.
45. Alguacil J, Porta M, Malats N, Kauppinen T, Kogevinas M, Benavides FG, et al. Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer. Carcinogenesis. 2002; 23(1): 101-6.
46. Major J, Jakab M, Kiss G, Tompa A. Chromosome aberration, sister-chromatid exchange, proliferative rate index, and serum thiocyanate concentration in smokers exposed to low-dose benzene.Environ Mol Mutagen. 1994; 23(2): 137–142.
47. Karacić V, Skender L, Bosner-Cucancić B, Bogadi-Sare A. Possible genotoxicity in low level benzene exposure. Am J Ind Med. 1995; 27(3): 379-88.
48. Li G, Yin S. Progress of epidemiological and molecular epidemiological studies on benzene in China. Ann N Y Acad Sci. 2006; 1076: 800-9.
49. Lam TH, Zhu CQ, Jiang CQ. Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China. Mutat Res. 2002; 515(1-2): 147-57.
50. Marcon F, Zijno A, Dobrowolny G, Carere A, Crebelli R. Detection of 1cen--1q12 lesions in different phases of the cell cycle: dual colour FISH analysis of peripheral lymphocytes from subjects with occupational exposure to petroleum fuels. Mutagenesis. 2002; 17(2): 157-62.
51. Chen S, Dong M, Zhu H, Wu T, Wang R, Xiao C, et al. Analysis for the titer of plasma antibody to heat stress protein 70 in workers exposed to benzene. Zhonghua Yu Fang Yi Xue Za Zhi. 2000; 34(1): 8-10.
52. Strücker I, Mandereau L, Aubert-Berleur MP, Déplan F, Paris A, Richard A, et al. Occupational paternal exposure to benzene and risk of spontaneous abortion. Occup Environ Med. 1994; 51(7): 475-8.
53. Chen D, Cho SI, Chen C, Wang X, Damokosh AI, Ryan L, et al. Exposure to benzene, occupational stress, and reduced birth weight. Occup Environ Med. 2000; 57(10): 661-7.
54. Cho SI, Damokosh AI, Ryan LM, Chen D, Hu YA, Smith TJ, et al. Effects of exposure to organic solvents on menstrual cycle length. J Occup Environ Med. 2001;43(6):567-75.
55. Qin KG, Hou YX, Zhang LY, Li MH, Yang SX, Ma Y. A case control study on the risk factors of male infertility. Zhonghua Liu Xing Bing Xue Za Zhi. 2003; 24(1): 30-2.
56. Parlayıcı, Patlayıcı, Tehlikeli ve Zararlı Maddelerle Çalışılan İşyerlerinde ve İşlerde Alınacak Tedbirler Hakkında Tüzük. Yürürlüğe Koyan Bakanlar Kurulu Kararnamesi: No: 7/7551- 27 Kasım 1978. Resmi Gazete: 24 Aralık 1973– 14752.