Murat SARI, Zahide Mine YAZICI, Nevruz ÖZDEMİR, Mustafa YANIK, Cüneyt ÜNERİ

The effect of vitamin e-coated tracheotomy cannula on tracheal reactive oxygen species

Amaç: Trakeotomi sonrası oluşan iyatrojenik havayolu travması önemli bir klinik sorun olmaya devam etmektedir. Trakeotomi kanülleri trakeada ve infraglottik bölgede önemli derecede darlık yapabilmektedir. Vitamin E bir antioksidan görevi görerek farklı serbest radikalleri ortadan kaldırır. Bu çalışmada vitamin E ile kaplanmış trakeotomi kanülü uygulamasının sıçanların trakeal dokularındaki serbest oksijen radikal miktarına etkisini inceledik. Gereçler ve Yöntemler: Erkek Sprague-Dawley sıçanlar her grupta altı hayvan olacak şekilde üç gruba ayrıldı. Birinci gruba normal trakeotomi kanülü, ikinci gruba ise E vitamini kaplanmış trakeotomi kanülü takıldı. Üçüncü grup kontrol grubu yapıldı. Hayvanlar sakrifiye edildi ve trakeal dokulara kemilüminesans incelemesi yapıldı. Bulgular: Reaktif oksijen türlerinin (ROT) seviyesi birinci grupta kontrol grubuna göre anlamlı derecede yükselmişti. İkinci gruptaki ROT seviyeleri ise birinci grupla karşılaştırıldığında istatistiksel olarak anlamlı derecede düşük bulundu. Sonuç: Sonuçlarımız göstermiştir ki, vitamin E trakeal dokuda trakeotomi nedeniyle oluşan ROT seviyesini düşürmektedir.

Vitamin E ile kaplanmış trakeotomi kanülünün trakeal reaktif oksijen türleri üzerine etkisi

Objectives: Iatrogenic airway injury after tracheotomy continues to be a serious clinical problem. Tracheotomy tubes can cause severe stomal stenosis in the trachea or infraglottic region. Vitamin E is a scavenger of different free radicals by working as an antioxidant. The aim of the present study was to evaluate the effect of vitamin E-coated tracheotomy tube insertion on the quantity of free radicals in rat tracheal tissue. Materials and Methods: Male Sprague-Dawley rats were divided into three groups of six animals each. Ordinary tracheotomy tubes were applied to the first group and vitamin E-coated tracheotomy tubes were applied to the second group. The third group was used as control. Animals were killed and chemiluminescence measurements were made for tracheal tissue. Results: Reactive oxygen species (ROS) levels were significantly increased in the first group of rats compared to those in control animals. ROS levels were statistically significantly decreased in the second group as compared to the first group. Conclusion: Our results indicate that vitamin E decreases tracheotomy-induced ROS levels in tracheal tissue.

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