Serum levels of antioxidant vitamins (vitamin A, C, E) and magnesium in children with allergic rhinitis

Amaç: Bu çalışmada allerjik rinit atakları esnasında antioksidan vitaminler ve magnezyum düzeylerinin ölçümü amaçlanmıştır. Hastalar ve Yöntemler: Çalışmaya orta persistan allerjik rinit tanısı konulan, diğer allerjik hastalıkları olmayan ve cilt testinde ev tozu akarlarına karşı hassasiyeti saptanan 35 hasta çalışma grubu, 35 sağlıklı çocuk kontrol grubu olarak alındı. Hasta grubu semptom skorlama sistemine göre sınıflandırıldı. Serum vitamin A, C, E ve magnezyum seviyelerini ölçmek için venöz kan örnekleri her grup için sabah kahvaltıdan önce alındı. Bulgular: Alerjik rinitli çocuklarda serum vitamin A düzeyi kontrol grubuna göre belirgin olarak düşük bulundu. Gruplar arasında serum vitamin C, E ve magnezyum seviyelerinde istatistiksel olarak anlamlı fark yoktu. Sonuç: Bu çalışmada, alerjik rinitte oksidatif harabiyeti önlemek ve inlamasyonla harap edilen mukozal epiteli tamir etmek için vitamin A'nın tüketildiği düşünülmektedir. Bu sonuç aynı zamanda da yeni tedavi yaklaşımlarını akla getirmektedir.

Allerjik rinitli çocuklarda antioksidan vitaminler (vitamin A, C, E) ve magnezyum düzeyleri

Objectives: The aim of the study is to measure the levels of antioxidant vitamins and magnesium during allergic rhinitis attacks. Patients and Methods: Thirty five children who have sensitivity for house dust and mite with mild/ moderate persistent allergic rhinitis without any other allergic diseases were considered as the study group, and 35 healthy children as the control group. The patient group was classified according to the symptom scoring system. Venous blood samples were obtained before breakfast in each group to determine serum vitamin A, C, E and magnesium levels. Results: Serum vitamin A level was significantly lower in the study group compared with the control group. However, there was no statistically significant difference between the groups in terms of serum vitamin C, E and magnesium levels. Conclusion: This study showed that vitamin A consumption increases to repair mucosal epithelium which is damaged by inflammation and to prevent the oxidative damage in allergic rhinitis. This result may imply new therapeutic approaches.

PDF

___

1) Sly RM. Changing prevalence of allergic rhinitis and asthma. Ann Allergy Asthma Immunol 1999;82:233-48.
2) Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol 2001;108(1 Suppl):S2-8.
3) Bolzán AD, Bianchi MS, Bianchi NO. Superoxide dismutase, catalase and glutathione peroxidase activities in human blood: influence of sex, age and cigarette smoking. Clin Biochem 1997;30:449-54.
4) Diplock AT. Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr 1991;53(1 Suppl):189S-193S.
5) Ratnam DV, Ankola DD, Bhardwaj V, Sahana DK, Kumar MN. Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. J Control Release 2006;113:189-207.
6) Di Mascio P, Devasagayam TP, Kaiser S, Sies H. Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. Biochem Soc Trans 1990;18:1054-6.
7) Bousquet J, Van Cauwenberge P, Khaltaev N; Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108(5 Suppl):S147-334.
8) Meltzer EO. Allergic rhinitis: managing the pediatric spectrum. Allergy Asthma Proc 2006;27:2-8.
9) Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med 1990;9:235-43.
10) van Asbeck BS, Hoidal J, Vercellotti GM, Schwartz BA, Moldow CF, Jacob HS. Protection against lethal hyperoxia by tracheal insufflation of erythrocytes: role of red cell glutathione. Science 1985;227:756-9.
11) Unal M, Tamer L, Pata YS, Kilic S, Degirmenci U, Akbaş Y, et al. Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis. J Trace Elem Med Biol 2004;18:189-92.
12) Arora P, Kumar V, Batra S. Vitamin A status in children with asthma. Pediatr Allergy Immunol 2002;13:223-6.
13) Shoseyov D, Bibi H, Biesalski H, Reifen R. Repeated allergen challenge in rats increases vitamin A consumption. Chest 2002;122:1407-11.
14) Cser MA, Majchrzak D, Rust P, Sziklai-László I, Kovács I, Bocskai E, et al. Serum carotenoid and retinol levels during childhood infections. Ann Nutr Metab 2004;48:156-62.
15) Kalayci O, Besler T, Kilinç K, Sekerel BE, Saraçlar Y. Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. Turk J Pediatr 2000;42:17-21.
16) Harik-Khan RI, Muller DC, Wise RA. Serum vitamin levels and the risk of asthma in children. Am J Epidemiol 2004;159:351-7.
17) Kompauer I, Heinrich J, Wolfram G, Linseisen J. Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisation in adults. Public Health Nutr 2006;9:472-9.
18) Podoshin L, Gertner R, Fradis M. Treatment of perennial allergic rhinitis with ascorbic acid solution. Ear Nose Throat J 1991;70:54-5.
19) Montaño Velázquez BB, Jáuregui-Renaud K, Bañuelos Arias Adel C, Ayala JC, Martínez MD, Campillo Navarrete R, et al. Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2006;96:45-50.
20) Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2004;92:654-8.
21) Swain R, Kaplan-Machlis B. Magnesium for the next millennium. South Med J 1999;92:1040-7.
22) Vural H, Uzun K, Uz E, Koçyigit A, Cigli A, Akyol O. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma. J Trace Elem Med Biol 2000;14:88-91.