Nevin TÜTEN, Koray GÖK, Mine KUCUR, Abdullah AÇIKGÖZ, Abdullah TÜTEN, Mahmut ONCUL

Fetal Gelişim ve Büyümede Apelinin Rolü

Amaç: Umblikal kordon kanı serum apelin düzeyinin yenidoğanın doğum ağırlığı ve insülin direnci üzerinde etkisini belirlemektir. Gereç ve Yöntem: Benzer vücut kitle indeksine(VKİ) sahip, gestasyonel diyabeti bulunmayan annelerin gebelik haftasına göre büyük (GHB) ve gebelik haftasıyla uyumlu (GHU) yenidoğanlarından umblikal kordon kanı alındı. İşlem sonrası umblikal kordon kanı serumunda glukoz, insülin ve apelin düzeyi ölçüldü. Sonuçlarla HOMA-IR hesaplandı. Gruplar arasında demografik, klinik ve laboratuvar sonuçları karşılaştırıldı. Bulgular: Umblikal kordon kanı serum glukoz düzeyi açısından gruplar arasında fark saptanmadı. Ancak, umblikal kordon kanı serum insülin ve apelin düzeyi yüksek saptandı (sırasıyla, 11,7 ± 3,1 mIU/L, 6,8 ± 1,1 mIU/L, p:0,001, 10,4±4,2 ng/ml, 7,8±1,7 ng/ml, p:0,011). HOMA-IR değeri GHB grubunda daha yüksek hesaplandı (sırasıyla 3,0±1,2, 1,7±0,6, p:0,001). Umblikal kordon kanı serum apelin düzeyi ile doğum ağırlığı (r = 0.399, p = 0.006), umblikal kordon kanı serum insülin düzeyi (r:0,873, p:0,001) ve HOMA- IR değeri (r: 0,938, p:0,001) arasında istatistiksel açıdan anlamlı pozitif korelasyon saptanırken umblikal kordon kanı serum glukoz düzeyiyle herhangi bir korelasyon saptanmadı. Sonuç: GHB grubunda umblikal kordon kanı serum apelin düzeyinin daha yüksek olduğu tespit edildi. Bu düzeyin yenidoğanın doğum ağırlığı ve insülin direnciyle pozitif korele olduğu belirlendi.

Anahtar Kelimeler:

apelin, doğum ağırlığı, İnsülin, HOMA-IR

The Role OF APELIN in Fetal Growth and development

Objective: To determine the effect of umbilical cord blood serum apelin level on newborn birth weight and insulin resistance. Materials and Methods: Umbilical cord blood was obtained from newborns who were large for gestational age (LGA) and appropriate for gestational age (AGA) of mothers who had similar body mass index (BMI) and did not have gestational diabetes. Glucose, insulin and apelin levels were measured in umbilical cord blood serum after the procedure. HOMA-IR was calculated with the results. Demographic, clinical and laboratory results were compared between the groups. Results: There was no difference between the groups in terms of umbilical cord blood serum glucose level. However, umbilical cord blood serum insulin and apelin levels were found to be high (11.7 ± 3.1 mIU/L, 6.8 ± 1.1 mIU/L, p:0.001, 10.4±4.2 ng/L, respectively). ml, 7.8±1.7 ng/ml, p:0.011). The HOMA-IR value was higher in the LGA group (3.0±1.2, 1.7±0.6, p:0.001, respectively). While a statistically significant positive correlation was found between umbilical cord blood serum apelin level and birth weight(r = 0.399, p = 0.006) , umbilical cord blood serum insulin level (r:0,873, p:0,001) and HOMA-IR value (r: 0,938, p:0,001) , it was not determined by umbilical cord blood serum glucose level. Conclusion: Umbilical cord blood serum apelin level was found to be high in the LGA group. This level was found to be positively correlated with newborn birth weight and insulin resistance.

Keywords:

Apelin, birth weight, Insulın, HOMA-IR,

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