SOLUNUM RİTMİNİN NÖROMODÜLASYONU

Solunum, neokorteks, serebellum, pons, medulla, spinal kord ve çeşitli diğ er subkortikal bo lğeleri içeren kompleks sinir ağ ları tarafından kontrol edilmektedir. PreBo tzinğer kompleksi (preBo tC), ventrolateral medulla içerisinde olup solunum ritminin oluşturulmasında o nemli yer almaktadır. Solunum ritminin kontrolu nde başlıca no romodu lato rler rol oynamaktadır. Son yıllarda, solunum u zerine etki ğo steren yeni no romodu lato rlerin bulunması ile solunumun kontrolu daha iyi anlaşılmaktadır. Asetilkolin, Noradrenalin, Serotonin, P Maddesi, Dopamin, Kolesistokinin, Tirotiropin Salğılattırıcı Hormon, Somatostatin, Histamin ve Opioidler solunum ritminin kontrolu nde yer alan başlıca no romodu lato rlerdir. Bu derlemede, preBo tzinğer kompleksi, inspirasyon no ronlarının aktivasyonu ve inhibisyonunda ğo rev alan temel no romodu lato r yolaklar ve etkileri ele alınmıştır

NEUROMODULATION OF RESPIRATORY RTHYM

Breathinğ is controlled by a complicated network involvinğ areas in the neocortex, cerebellum, pons, medulla, spinal cord, and various other subcortical reğions. The pre-Botzinğer complex that located within the ventrolateral medulla has an important effect in ğeneratinğ of respiratory rhythm. Neuromodulators act a key role in the control of respiratory rhythm. In recent years, with findinğ new neuromodulators which show effects on breathinğ, control of breathinğ is understood well. Acetylcholine, Noradrenaline, Serotonin, Substans P, Dopamine, Cholecystokinin, Thyrotropin-Releasinğ Hormone, Somatostatin, Histamine and Opioids are mainly neuromodulators which appear in the control of the respiratory rthym. In this review, pre-Bo tzinğer Complex, main neuromodulator pathways which participate activation and inhibition of inspiratory neurons are handled

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