Hamide Eda TATLIPINAR, HAVA ÜSKÜDAR TEKE, Neslihan ANDIÇ, FUNDA CANAZ, EREN GÜNDÜZ, Olga Meltem AKAY

Lökomoid Reaksiyon ve Konglemere Lenfadenopatiler İle Prezente Olan Granülositik Sarkom Olgusu

Granülositik sarkom, myeloid seri progenitör hücrelerini içeren ekstrameduller alanlarda yer alan tümöral bir kitledir. Genellikle kemik, periost, yumuşak dokuda lokalize olurlar. Granülositik sarkom, çok yaygın olarak, akut myeloid löseminin klinik bir başlangıç bulgusu olarak kendini gösterebilir. 42 yaşında olan ve boğaz ağrısı nedenli kliniğimize başvuran olgumuzun fizik muayenesinde tonsiller hipertrofik, hepatosplenomegali ve multipl konglemere özellikte lenfadenopatileri mevcuttu. Laboratuvar incelemesinde, hemoglobin 7.2 gr/dl, lökosit 144x109/L platelet 36x109/L saptandı. Periferik yayma ve kemik iliği aspirasyon bulguları ile akut veya kronik myeloid lösemi düşünülmeyen hastaya lenfoma ön tanısı ile eksizyonel lenf nodu biyopisi yapıldı ve biyopsi sonucu granulositik sarkom ile uyumlu saptanarak 7+3 remisyon-indüksiyon kemoterapisi başlandı. Hasta progresyon ve sepsis nedenle ex oldu. Sonuç olarak; lökomoid reaksiyonla gelen ve patolojik lenfadenopatileri olan hastalarda tabloya granülositik sarkomun eşlik edebileceği düşünülmeli ve doku tanısı ile ön tanı desteklenmelidir.

Anahtar Kelimeler:

Lenfadenopati, granulositik sarkom

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