Fatma AYDIN, Hülya ANIL, Abdülkadir KOÇAK, KORAY HARMANCI, GÜRKAN BOZAN

Çocuklardaki Alerjik Rinit, Astım ve Atopik Dermatitle Adipokinlerin İlişkisi

Adipokinler ile alerjik hastalıklar arasında giderek artan oranda bir ilişki saptanmasına rağmen, altta yatan mekanizmalar hakkında elimizde çok az veri bulunmaktadır. Bu çalışmada plazma leptin ve adiponektin konsantrasyonlarının astım ve diğer alerjik hastalıklarla olan ilişkisinin incelenmesi amaçlanmıştır. Astım, alerjik rinit ve atopik dermatitli 71 hasta ve 54 sağlam çocuk çalışmaya alınmıştır. Vücut kitle indeksleri, solunum fonksiyon testleri ve deri prick testleri yapılan hastalardan total eozinofil sayısı, total serum Immunglobulin E, spesifik Immunglobulin E (phadiotop), leptin ve adiponektin düzeyleri için kan alınmıştır. Plazma leptin konsantrasyonu ile vücut kitle indeksi arasında pozitif korelasyon saptanırken, plazma adiponektin düzeyleri ile vücut kitle indeksi arasında negatif korelasyon saptanmıştır. Atopik dermatitli çocuklar diğer hasta ve sağlıklı çocuklara göre daha yüksek leptin düzeylerine sahiplerdi. Fakat adiponektin düzeyleri açısından böyle bir yüksekliğe rastlanmadı. Serum leptin düzeyleri ile vücut kitle indeksi arasında güçlü bir pozitif korelasyon saptandı. Bu sonuçlara göre serum leptin düzeyleri çocuklarda atopik dermatit riskiyle ilişkilendirilebilirken, adiponektin düzeyleriyle böyle bir ilişki saptanmamıştır.

Anahtar Kelimeler:

Astım, leptin, adiponektin, alerjik rinit

Associatıons of Adipokines with Allergic Rhinitis, Asthma and Atopic Dermatitis in Children

There is growing evidence for an association between adipokines and allergic disorders but little is known about the underlying mechanisms. We hypothesized that high plasma leptin and adiponectin concentrations might be related to asthma and the other allergic diseases. We studied 71 children with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) and 54 healthy children. Body mass indexes, pulmonary function tests and skin prick test were performed. Total eosinophil count, total serum immunoglobulin E (IgE), serum spesific IgE (phadiotop) leptin and adiponectin were measured in all subjects. There was a strong positive correlation for plasma leptin concentrations with body mass index BMI, Adiponectin, however, was negatively correlated with BMI. Children with atopic dermatitis had higher leptin levels compared with the other allergic diseases and control groups, but adiponectin did not show any difference among these three groups. Serum leptin levels are strongly correlated with measures of BMI. These results suggest that leptin may contribute to increased atopic dermatitis risk in children. but no correlation was found with plasma adiponectin concentrations

Keywords:

Asthma, leptin, adiponectin, allergic rhinitis,

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