ÖMER ÖZÇAĞLAYAN, TUĞBA İLKEM KURTOĞLU ÖZÇAĞLAYAN, AHMET MESRUR HALEFOĞLU

TİROİD NODÜLLERİNDE MALİGN VE BENİGN AYRIMINDA DİFÜZYON AĞIRLIKLI MANYETİK REZONANS İNCELEMENİN YERİ

Amaç: Bu çalışmanın amacı, Difüzyon Ağırlıklı Manyetik Rezonans Görüntülemenin (DAMRG) tiroid nodüllerinde malign-benign ayrımındaki yerini araştırmak idi. Materyal ve Metot: Çalışmaya tiroid nodülü ve patolojik tanısı olan 39 hasta ve 40 nodül dahil edildi. İzlenen nodüller, DAMRG ile incelendi ve elde edilen Apparent Diffusion Coefficient (ADC) değerleri ve patolojik sonuçlar arasındaki ilişki istatistiksel olarak değerlendirildi. Bulgular: Nodüllerin 9’u malign, 31’i benign karakterdeydi. Malign ve benign nodüllerin ortalama ADC değerleri sırasıyla (1,60±0,29)x10⁻³ sn/mm²)ve (2,14±0,39)x10⁻³ sn/mm²) bulundu. Malign ve benign nodüllerin ADC değerleri arasında anlamlı istatistiksel farklılık izlendi (p

THE ROLE OF DIFFUSION WEIGHTED MAGNETIC RESONANCE IMAGING IN THE DISCRIMINATION OF MALIGNANT AND BENIGN THYROID NODULES

Aim: The aim of this study was to investigate the role of the Diffusion Weighted Imaging (DWI) sequences in diagnosis of malignant and benign nodules of thyroid nodules. Materials and Methods: Thirty nine patients and fourty nodules were enrolled to the study. The observed nodules were examined with DWI. Relationship between obtained Apparent Diffusion Coefficient (ADC) values and pathological results were statistically evaluated.. Results: There were 9 malignant and 31 benign nodules. Mean ADC values were evaluated (1.60±0.29)x10⁻³ sn/mm² for malignant, and (2.14±0.39)x10⁻³ sn/mm²) for benign nodules, respectively. There was a statistical difference between ADC values of malignant and benign nodules (p

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1. Yang J, Schnadig V, Logrono R, Wasserman PG.Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer. 2007;111(5):306-15.
2. Koh DM, Collins DJ. Diffusion-weighted MRI in the body: applications and challenges in oncology. American Journal of Roentgenology. 2007;188: 1622-1635.
3. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, et al. Society of Radiologists in Ultrasound. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005;237(3):794-800.
4. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab. 2008;22(6):901-11.
5. Hegedus L. The thyroid nodule. N Engl J Med. 2004; 351:1764-71.
6. Wong KT, Ahuja AT. Ultrasound of thyroid cancer. Cancer Imaging. 2005;(5):157-66.
7. Gharib H. Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations, and effect. Mayo Clin Proc. 1994;69(1):44-9.
8. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. American Thyroid Association Guidelines Taskforce. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006;16(2):109-42.
9. Tollin SR, Mery GM, Jelveh N, Fallon EF, Mikhail M, Blumenfeld W, Perlmutter S. The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter. Thyroid. 2000;10(3):235-41.
10. Shetty SK, Maher MM, Hahn PF, Halpern EF, Aquino SL. Significance of incidental thyroid lesions detected on CT: correlation among CT, sonography, and pathology. Am J Roentgenol. 2006;187(5):1349-56.
11. Burke JS, Butler JJ, Fuller LM. Malignant lymphomas of the thyroid: a clinical pathologic study of 35 patients including ultrastructural observations. Cancer. 1977;39(4):1587-602.
12. Radecki PD, Arger PH, Arenson RL, Jennings AS, Coleman BG, Mintz MC, Kressel HY. Thyroid imaging: comparison of high-resolution real-time ultrasound and computed tomography. Radiology. 1984;153(1):145-7.
13. Higgins CB, McNamara MT, Fisher MR, Clark OH. MR imaging of the thyroid. AJR Am J Roentgenol. 1986;147(6):1255-61.
14. Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR imaging of the brain. Radiology. 2000; 217(2):331-45.
15. Razek AA,Sadek AG,Kombar OR, Elmahdy TE, Nada N. Role of apparent diffusion coefficient values in differentiation between malignant and benign solitary thyroid nodules. Am J Neuroradiol. 2008;29(3):563-8.
16. Schueller-Weidekamm C, Kaserer K, Schueller G, Scheuba C, Ringl H, Weber M, et al. Can quantitative diffusion-weighted MR imaging differentiate benign and malignant cold nodules? Initial results in 25 patients. Am J Neuroradiol. 2009;30(2):417-22.
17. Bozgeyik Z, Coskun S, Dagli AF, Ozkan Y, Sahpaz F, Ogur E. Diffusion-weighted MR im- aging of thyroid nodules. Neuroradiology. 2009;51(3):193-8.
18. Erdem G, Erdem T, Muammer H, Mutlu DY, Firat AK, Sahin I, et al. Diffusion-weighted images differentiate benign from malignant thyroid nodules. J Mag Reson Imaging. 2010;31(1):94-100.
19. Halefoglu AM, Ozcaglayan O, Ozel D, Duran Ozel B, Ozcaglayan Tİ. ADC Values in Distinction of Benign and Malignant Thyroid Nodules. World Clin J Med Sci. 2017;1(2):96-102.
20. Cova M, Squillaci E, Stacul F, Manenti G, Gava S, Simonetti G, Pozzi-Mucelli R. Diffusion-weighted MRI in the evaluation of renal lesions: preliminary results. Br J Radiol. 2004 Oct;77(922):851-7.specialists: critical evaluation. Ital J Neurol Sci.1998;19(4):195–203.
21. Di Fabio R, Castagnoli C, Madrigale A, Barella M, Serrao M, Pierelli F. Requests for electromyography in rome: a critical evaluation. Funct Neurol. 2013; 28(4):281-4.