Kağan GÖKÇE, Cihan AYDİN, Emrah DOĞAN, Serkan YAZMAN

Senkron Derin Ven Trombozu ve Pulmoner Embolisi Olan Mide Kanserli Hasta: Olgu Sunumu

Venöz tromboemboli (VTE), derin ven trombozu (DVT) ve pulmoner emboli (PE)’den oluşur. VTE’nin genel popülasyonda yıllık görülme oranı her 100.000’de 117’dir. VTE önemli bir morbidite ve mortalite kaynağıdır. Kanserle ilişkili gelişen VTE’nin görülme insidansı daha fazladır ve sonuçları daha dramatiktir. Mide kanseri en sık görülen ve ölüme yol açan altıncı kanser tipidir. Mide kanserinin en sık görülen histolojik subtipi adenokarsinomdur. Mide kanseri, pankreas ve akciğer kanserinden sonra kansere bağlı tromboemboli riski en yüksek olan üçüncü kanser tipidir. Kansere bağlı gelişen VTE’de esas tedavi düşük molekül ağırlıklı heparindir (DMAH). Bu vaka takdiminin amacı; DMAH tedavisi altında ameliyat edilen, 76 yaşında, senkron venöz trombozu ve pulmoner embolisi olan mide kanserli erkek hastayı sunmaktır.

Anahtar Kelimeler:

Derin Ven Trombozu, Mide Kanseri, Pulmoner Emboli

Synchronous Deep Venous Thrombosis and Pulmonary Embolism in Stomach Cancer Patient: Case Report

Venous thromboembolism (VTE) consists of deep vein thrombosis (DVT) and pulmonary embolism (PE). The annual incidence of VTE in the general population is 117 per 100000. VTE is an important cause of morbidity and mortality. The incidence of cancer-associated VTE is higher and the results are more dramatic. Stomach cancer is the sixth most common type of cancer that causes death. The most common histological subtype of stomach cancer is adenocarcinoma. Stomach cancer is the third type of cancer that has the highest risk of cancer related thromboembolism after pancreatic and lung cancer. The main treatment in cancer related VTE is low molecular weight heparin (LMWH). The aim of this case report is to present a 76 years old male patient with stomach cancer, synchronous venous thrombosis and pulmonary embolism, who underwent surgery under LMWH treatment.

Keywords:

Deep Venous Thrombosis, Pulmonary Embolism, Stomach Cancer,

PDF

___

1. Wu C, Lee AY. Novel or Non–Vitamin K Antagonist Oral Anticoagulants and the Treatment of Cancer-Associated Thrombosis Semin Thromb Hemost. 2015;41(2):237–43.
2. Walker AJ, Card TR, West J, Crooks C, Grainge MJ.Incidence of venous thromboembolism in patients with cancer-a cohort study using linked United Kingdom databases. Eur J Cancer 2013;49(6):1404–13.
3. Ben-Aharon I, Stemmer SM, Leibovici L, Shpilberg O, Sulkes A, Gafter-Gvili A. Low molecular weight heparin (LMWH) for primary thrombo-prophylaxis in patients with solid malignancies–systematic review and meta-analysis. Acta Oncologica. 2014;53(9):1230–7.
4. Farge D, Bounameaux H, Brenner B, et al. Implementing Thrombosis Guidelines in Cancer Patients: A Review. Rambam Maimonides Med J. 2014;5(4):0041.
5. Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest 2001;119(1):132–75.
6. Wada T, Fujiwara H, Morita S, Fukagawa T, Katai H.Incidence of and risk factors for preoperative deep venous thrombosis in patients undergoing gastric cancer surgery. Gastric Cancer 2017;20(5):872–7.
7. Kakkar AK, DeRuvo N, Chinswangwatanakul V, Tebbutt S, Williamson RC. Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor. Lancet. 1995;346(8981):1004–5.
8. Rickles FR, Brenner B. Tissue factor and cancer. Semin Thromb Hemost. 2008;34(2):143–5.
9. Hoffman R, Haim N, Brenner B. Cancer and thrombosis revisited. Blood Rev. 2001;15(2):61–7.
10. Khorana AA, Liebman HA, White RH, et al. The Risk of Venous Thromboembolism in Patients with Cancer. American Society of Clinical Oncology; ASCO Educational Book; 2008;240–8.
11. Marshall-Webb M, Bright T, Price T, et al. Venous thromboembolism in patients with esophageal or gastric cancer undergoing neoadjuvant chemotherapy. Dis Esophagus. 2017;30(2):1–7.
12. Elyamany G, Alzahrani A.M, Bukhary E. Cancer-Associated Thrombosis: An Overview. Clin Med Insights Oncol. 2014;8:129-37.
13. Martin MJ, Blair KS, Curry TK, Singh N. Vena cava filters: current concepts and controversies for the surgeon. Curr Probl Surg. 2010;47(7):524–618.
14. Rojas-Hernandez CM, Zapata-Copete JA, García-Perdomo HA. Role of vena cava filters for the management of cancer-related venous thromboembolism: Systematic review and meta-analysis. Crit Rev Oncol Hematol. 2018;130:44–50.